Nateglinide is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Nateglinide has been linked to rare instances of clinically apparent acute liver injury[3]. Nateglinide is an oral hypoglycemic agent approved for use alone or in combination with metformin as an adjunct to diet and exercise for the treatment of type 2 diabetes mellitus. Nateglinide is highly bound to plasma proteins, is metabolized extensively by the liver, and has an elimination half-life of 1.4 hours. Several clinical trials of nateglinide, alone and in combination with other oral hypoglycemic agents, have found the drug to be safe, effective, and well tolerated. The most common adverse effects are nausea, diarrhea, dizziness, and lightheadedness. There is a potential for interactions between nateglinide and medications affected by the cytochrome P-450 isoenzyme system[4]. Nateglinide 120 mg plus metformin 500 mg, both 3 times daily, conferred greater glycaemic improvement than either drug given alone, and nateglinide 60 or 120 mg 3 times daily plus metformin 1 g twice daily was superior to metformin plus placebo[5].
Nateglinide/那格列萘 细胞实验
Cell Line
Concentration
Treated Time
Description
References
BRIN-BD11 cells
100 μM
18 h
18-hour exposure to 100 mM nateglinide abolished the acute insulinotropic effects of nateglinide, tolbutamide, and glibenclamide, but did not affect the insulinotropic effect of efaroxan.
Br J Pharmacol. 2004 May;142(2):367-73.
BRIN-BD11 cells
10–400 μM
20 min
Nateglinide induced a concentration-dependent increase in insulin release at non-stimulatory glucose concentrations and evoked K ATPchannel-independent insulin secretion in depolarized cells.
Br J Pharmacol. 2004 May;142(2):367-73.
Nateglinide/那格列萘 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
Streptozotocin (STZ)-induced diabetic mice
Oral
150 mg/kg
Every 3 days for 130 days
To evaluate the effectiveness of Ins@Alg/NG in regulating blood glucose levels in diabetic mice, results showed that Ins@Alg/NG significantly reduced blood glucose levels and restored pancreatic function.
Japan
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Nagoya-shi, Aichi, Japan
Fukuoka-shi, Fukuoka, Japan
Kurume-shi, Fukuoka, Japan
Sapporo-shi, Hokkaido, Japan
Kobe-shi, Hyogo, Japan
Kagoshima-shi, Kagoshima, Japan
Kumamoto-shi, Kumamoto, Japan
Osaki-shi, Miyagi, Japan
Minou-shi, Osaka, Japan
Osaka-shi, Osaka, Japan
Kamio-shi, Saitama, Japan
Koshigaya-shi, Saitama, Japan
Adachi-ku, Tokyo, Japan
Chuo-ku, Tokyo, Japan 收起 <<
United States, Florida
... 展开 >>
University of Miami
Recruiting
Miami, Florida, United States
Contact: Gianluca Iacobellis, MD GIacobellis@med.miami.edu
Principal Investigator: Gianluca Iacobellis, MD
United States, Georgia
Grady Memorial Hospital
Recruiting
Atlanta, Georgia, United States, 30303
Contact: Guillermo E Umpierrez, MD 404-778-1665 geumpie@emory.edu
Contact: Francisco J Pasquel, MD 404 778 1697 fpasque@emory.edu
Principal Investigator: Guillermo Umpierrez, MD
Sub-Investigator: Francisco J Pasquel, MD
Sub-Investigator: Priya Vellanki, MD
Emory University Hospital
Recruiting
Atlanta, Georgia, United States, 30324
Contact: Francisco Pasquel, MD fpasque@emory.edu
Sub-Investigator: Francisco Pasquel, MD
Emory Universtiy Hospital at MIdtown
Recruiting
Atlanta, Georgia, United States
Contact: Francisco Pasquel, MD
Sub-Investigator: Rodolfo J Galindo, MD
United States, New York
State University of NY at Buffalo
Recruiting
New York, New York, United States
Contact: Ajay Chaudhuri, MD AChaudhuri@KaleidaHealth.Org
Principal Investigator: Ajay Chaudhuri, MD 收起 <<
China, Jiangsu
... 展开 >> The First People's Hospital of Changzhou
Changzhou, Jiangsu, China
The Second People's Hospital of Huai'an
Huai'an, Jiangsu, China
Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Southeast University
Nanjing, Jiangsu, China
Xuzhou Central Hospital
Xuzhou, Jiangsu, China
Yancheng City No.1 People's Hospital
Yancheng, Jiangsu, China
Zhenjiang First People's Hospital
Zhenjiang, Jiangsu, China 收起 <<
United States, Washington
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VA Puget Sound Health Care System (Seattle Campus)
Seattle, Washington, United States, 98108
VA Puget Sound Health Care System (American Lake Campus)
Tacoma, Washington, United States, 98493 收起 <<
Japan
... 展开 >> Nippon Kokan Hospital
Kawasaki, Kanagawa, Japan, 210-0852
Hamamatsu Red Cross Hospital
Hamamatsu, Shizuoka, Japan, 430-0907
Saiseikai Central Hospital
Minato-ku, Tokyo, Japan, 108-0073
Kitasato Institute Hospital
Minato-ku, Tokyo, Japan, 108-8642
Keio University Hospital
Shinjuku-ku, Tokyo, Japan, 160-8582
Tokyo Metropolitan Ohtsuka Hospital
Toshima-ku, Tokyo, Japan, 170-8476 收起 <<
Type 2 Diabetes Mellitus
... 展开 >> Diabetes Mellitus, Type II 收起 <<
Phase 2
Phase 3
Completed
-
Japan
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Chubu region, Japan
Chugoku region, Japan
Hokkaido region, Japan
Kanto region, Japan
Kinki region, Japan
Kyushu region, Japan
Tohoku region, Japan 收起 <<
Korea, Republic of
... 展开 >>
Paik Diabetes Center, Pusan Paik Hospital, College of Medicine, Inje University
Busan, Korea, Republic of, 614-735
Endocrinology and Metabolism, Maryknoll General Hospital
Busan, Korea, Republic of 收起 <<
Sweden
... 展开 >> Department of Surgery, Unit of Vascular Surgery, Södersjukhuset
Recruiting
Stockholm, Sweden, SE-11883
Contact: Sara Haile, RN +46 8 6162462 sara.haile@sodersjukhuset.se
Principal Investigator: Anneli Linné, MD, PhD
Karolinska University Hospital, Dept of Vascular Surgery
Recruiting
Stockholm, Sweden
Contact: Ulrika Palmer Kazen, MD, PhD 08-51770000
Principal Investigator: Ulrika Palmer Kazen, MD, PhD 收起 <<
China
... 展开 >> People's Liberation Army. The Military General Hospital of BeiJing
BeiJing, China, 100020
Peiking University First Hospital
BeiJing, China, 100034
Chinese PLA General Hospital
Beijing, China, 100853
The First Affiliated Hospital, Zhongshan (Sun Yat-sen) University
Guangzhou, China, 510080
The Second Affiliated Hospital, Zhongshan (Sun Yat-sen) University
Guangzhou, China, 510120
Nanfang Hospital, the Affiliated South Hospital of the Southern Medical University
Guangzhou, China, 510515 收起 <<
Korea, Republic of
... 展开 >>
Myongji Hospital
Ilsan, Kyounggi, Korea, Republic of
Hanyang University Medical Center
Guri-si, Kyunggi-do, Korea, Republic of
Inha University Hospital
Incheon, Korea, Republic of
Hallym University Medical Center
Seoul, Korea, Republic of
Korea University Guro Hospital
Seoul, Korea, Republic of
Kyung hee University Medical Center
Seoul, Korea, Republic of
Ajou University Hospital
Suwon-si, Korea, Republic of 收起 <<
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