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货号 产品名 纯度
A1216733 Tipepidine HCl/盐酸替比啶

98%
A458603 ICA-27243

95%
A1251848 ML67-33

98%
A1581521 ICA-105574

99%+
A189693 Disopyramide phosphate

98%
A1177118 VU0134992

98%+
A1523655 Azetukalner

98%
A793489 Pinacidil/吡那地尔

98%+
A1499641 RU-TRAAK-2

RU-TRAAK-2是一种完全可逆的TRAAK通道抑制剂,在非K2P通道(Kv1.2,Slo1,GIRK2)上没有活性。

98%
A397321 BMS-191011

BMS-191011 (BMS-A) is an opener of the large-conductance, Ca2+-activated potassium (maxi-K) channel, effective in stroke models. It has also shown neuroprotective properties in two distinct animal models of stroke- MCAO in the SHR rat and a normotensive model of focal stroke.

99%+
A127678 Mitiglinide calcium/米格列奈钙

Mitiglinide calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells.

98%
A463680 Linopirdine dihydrochloride

Linopirdine 2HCl is a blocker of KV7 (KCNQ) voltage-gated potassium channels which blocks KV7.1 + 7.3 (KCNQ2 + 3) / M-currents (IC50 = 4 - 7 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 8.9 μM), and is a putative cognition-enhancing drug.

98%+
A725210 Cloperastine fendizoate/氯苄哌醚联苯酰苯酸盐

Cloperastine fendizoate inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM.

98%
A226793 SKA-31

SKA 31 is an activator of KCa3.1 and KCa2 channels with EC50 of 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively.

98%
A268758 XE 991 2HCl/XE-991二盐酸盐

XE991 2HCl is a potent and selective blocker of KV7 (KCNQ) voltage-gated potassium channels which blocks KV7.2+7.3 (KCNQ2+3) / M-currents (IC50 = 0.6 - 0.98 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 0.75 μM) but is less potent against KV7.1/minK channels (IC50 = 11.1 μM).

99%+
A239139 GAL-021

GAL-021 a new intravenous Potassium Channel KCa1.1 blocker.

98%+
A540552 Minoxidil Sulfate/米诺地尔 硫酸盐

Minoxidil sulfate is a K+ channel agonist and a strong vascular smooth muscle relaxant. It has been shown to relax norepinephrine contraction, and is reported to be a vasodilator. Minoxidil sulfate has been used to better understand the blood-brain tumor barrier in syngeneic and allogeneic rat studies and has demonstrated to increase tumor permeability.

98%
A625194 Talatisamine/塔拉萨敏

Talatisamine, a delphinine type alkaloid extracted from Aconitum talassicum, is specific K+ channel blocker with hypotensive and antiarrhythmic activities. Talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons.

98%
A266716 VU 0240551

VU 0240551 is a small molecule inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC50 = 560 nM for K+ uptake assay in KCC2-overexpressing cells).

99%+
A1209586 ML 297

ML 297 is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM.

99%+
产品名 Potassium Channel 其他靶点 纯度
Tolbutamide 98%
Glimepiride ++++

SUR2B, IC50: 7.3 nM

SUR1, IC50: 5.4 nM

97%
Dronedarone Hydrochloride 95%
Gliquidone ++

Potassium channel, IC50: 27.2 nM

98%
TRAM-34 +++

IKCa1 (KCa3.1), Kd: 20 nM

99%+
Glibenclamide 98%
Amiodarone HCl 97%
Gliclazide ++

Potassium channel, IC50: 184 nM

98%
Repaglinide 98%
Dofetilide 98%
Nateglinide 99%
Quinine hydrochloride dihydrate 98%
ML133 HCl +

Kir2.1, IC50: 290 nM

97%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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