Nigericin sodium salt
产品说明书
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同义名 : | 尼日利亚菌素钠 ;Nigericin Sodium; Nigericin (sodium salt); NSC 292567 |
| CAS号 : | 28643-80-3 | |
| 货号 : | A359670 | |
| 分子式 : | C40H67NaO11 | |
| 纯度 : | 98% | |
| 分子量 : | 746.94 | |
| MDL号 : | MFCD27977549 | |
| 存储条件： |
Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 12 mg/mL(16.07 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO 无水乙醇: 45 mg/mL(60.25 mM)，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇 |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Nigericin sodium is an antibiotic from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore, a NLRP3 activator. Nigericin (0.1 µM) inhibits proliferation, migration, invasion and clonogenicity of H460 lung cancer cells[3]. A 48-hr exposure of human erythrocytes to nigericin significantly increased the percentage of annexin-V-binding cells (0.1-10 nM) and Fluo3 fluorescence (0.1-10 nM), significantly decreased forward scatter (0.1-1 nM) and cytosolic pH (0.1-1 nM). Nigericin (1 nM) slightly, but significantly, increased ROS, but did not significantly modify ceramide abundance[4]. Nigericin could selectively target CSCs (Cancer stem cells) and sensitize CSCs in NPC (Nasopharyngeal carcinoma) to the widely used clinical drug cisplatin both in vitro and in vivo[5]. Nigericin exhibits great toxicity for the HT29 and SW116 cell line with IC50 of 12.92±0.25 μM and 15.86±0.18 μM. Nigericin also shows a decreased ability to form colonies under anchorage-independent conditions. HT29 cells treated with nigericin induced an increase in E-cadherin expression and a decrease in the vimentin expression relative to vehicle controls[6]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.34mL 0.27mL 0.13mL |
6.69mL 1.34mL 0.67mL |
13.39mL 2.68mL 1.34mL |
| 参考文献 |
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