Evaluate the effect of MF094 on neuronal survival rate, results showed maximum survival rate at 180 nmol/L
Transl Stroke Res. 2025 Apr;16(2):448-466
HTR-8/SVneo trophoblast cells
120 nM
24 hours
Increased FUNDC1 ubiquitination level, inhibited mitophagy and Δψm changes, reduced ROS and MDA, increased GSH and SOD, alleviated hypoxia-induced trophoblast cell injury
Bioengineered. 2022 Feb;13(2):3620-3633
HOEC cells
0.2 to 2 μM
12, 24, 48 hours
Evaluate the effect of MF-094 on cell viability, results showed that MF-094 significantly decreased the viability of HOEC cells
Cell Mol Biol Lett. 2022 Dec 6;27(1):107
HSC4 cells
0.05 to 2 μM
12, 24, 48 hours
Evaluate the effect of MF-094@NPs on cell viability, results showed that MF-094@NPs significantly decreased the viability of HSC4 cells
Cell Mol Biol Lett. 2022 Dec 6;27(1):107
MF-094 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Nude mice
SCC4 cell subcutaneous injection-induced xenograft tumor model
Tail vein injection
1 mg/kg/day
Once daily for 4 weeks
Evaluate the antitumor effect of MF-094@NPs, results showed that MF-094@NPs significantly inhibited tumor growth
Cell Mol Biol Lett. 2022 Dec 6;27(1):107
C57BL/6 J mice
Subarachnoid hemorrhage model
Lateral ventricular injection
5 mg/kg
Once daily until the end of the experiment
Evaluate the improvement effect of MF094 on neurological injury and inflammatory response after SAH, results showed 5 mg/kg dose significantly improved neurological function
搜索
