DL-Homocysteine | 2-氨基-4-巯基丁酸 | NSC 206252 | Neurotoxin

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H-DL-HoCys-OH/DL-高半胱氨酸 {[allProObj[0].p_purity_real_show]}

货号：A789113 同义名： 2-氨基-4-巯基丁酸 / NSC 206252; DL-Homocysteine

H-DL-HoCys-OH是一种神经毒素，能够影响犬尿酸的产生，进而影响认知功能和脑白质结构。它在研究神经系统疾病及相关代谢失调中具有应用前景。

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Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

H-DL-HoCys-OH/DL-高半胱氨酸化学结构
CAS号：454-29-5

H-DL-HoCys-OH/DL-高半胱氨酸 3D分子结构
CAS号：454-29-5

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H-DL-HoCys-OH/DL-高半胱氨酸纯度/质量文件产品仅供科研

货号：A789113 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]; • Cell, 2025. Ambeed. [ A122167 ]; • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]; • Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]; 更多 >

mTOR 亚型比较

产品名称	mTOR ↓ ↑	mTORC1 ↓ ↑	mTORC2 ↓ ↑	其他靶点	纯度
AZD-8055	++++ mTOR (full length), IC50: 0.8 nM mTOR (truncated), IC50: 0.13 nM				99%+
Gedatolisib	++++ mTOR, IC50: 1.6 nM				99%
GSK1059615	++ mTOR, IC50: 12 nM				98%
Vistusertib	+++ mTOR, IC50: 2.8 nM				99%+
Torin 1	+++ mTOR, IC50: 4.32 nM	+++ mTORC1, IC50: 2 nM	++ mTORC2, IC50: 10 nM	DNA-PK	99%+
Dactolisib	+++ mTOR (p70S6K), IC50: 6 nM				98+%
PI-103	+ mTOR, IC50: 30 nM				99%+
WAY-600	++ mTOR, IC50: 9 nM				99%
Voxtalisib	+ mTOR, IC50: 157 nM				99%+
PF-04691502	++ mTOR, Ki: 16 nM				98+%
Onatasertib	++ mTOR, IC50: 16 nM			DNA-PK	99%+
Chrysophanol	✔			EGFR	98%
Samotolisib	✔			DNA-PK	99%+
Torkinib	+++ mTOR, IC50: 8 nM			DNA-PK,PDGFR	99%+
Everolimus					99%+
WYE-354	+++ mTOR, IC50: 5 nM				98%
Tacrolimus	✔				98%
PP121	++ mTOR, IC50: 13 nM			VEGFR,PDGFR	99%+
Torin 2	++++ mTOR, IC50: 0.25 nM			DNA-PK	99%+
Rapamycin	++++ mTOR, IC50: ~0.1 nM				98%
GDC-0349	+++ mTOR, Ki: 3.8 nM				98%
XL388	++ mTOR, IC50: 9.9 nM	+++ mTORC1, IC50: 8 nM	+ mTORC2, IC50: 166 nM		99%+
WYE-687	+++ mTOR, IC50: 7 nM				98%
Apitolisib	+ mTOR, Ki app: 17 nM				98%+
WYE-132	++++ mTOR, IC50: 0.19 nM				99%+
Sapanisertib	++++ mTOR, Ki: 1.4 nM				99%+
BGT226 maleate	✔				99%+
ETP-46464	++++ mTOR, IC50: 0.6 nM			DNA-PK	98%
PI3K-IN-1	+ mTOR, IC50: 157 nM				98+%
Zotarolimus	+++ FKBP-12, IC50: 2.8 nM				98%
OSI-027	+++ mTOR, IC50: 4 nM	+ mTORC1, IC50: 22 nM	+ mTORC2, IC50: 65 nM		99%+
Ridaforolimus	++++ mTOR, IC50: 0.2 nM				99%+
Temsirolimus	+ mTOR, IC50: 1.76 μM				95%
CZ415	++ mTOR, pIC50: 8.07				99%+
SF2523	+ mTOR, IC50: 280 nM			DNA-PK	99%+
KU-0063794		++ mTORC1, IC50: ~10 nM	++ mTORC2, IC50: ~10 nM		99%+
Omipalisib		++++ mTORC1, Ki: 0.18 nM	++++ mTORC2, Ki: 0.3 nM		99%+
Palomid 529		✔			99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

H-DL-HoCys-OH/DL-高半胱氨酸细胞实验

Cell Line Neuro 2A (N2A) cells	Concentration	Treated Time	Description	References
Neuro 2A (N2A) cells	50 µM	24 hours	To investigate the effect of Hcy on 5LO expression levels and its DNA methylation, results showed that Hcy exposure led to a significant increase in 5LO protein and mRNA levels, accompanied by elevated SAH and reduced SAM levels	Aging Cell. 2017 Apr;16(2):273-280.

H-DL-HoCys-OH/DL-高半胱氨酸动物实验

Species ApoE-/- mice	Animal Model Hyperhomocysteinemia-accelerated atherosclerosis model	Administration	Dosage	Frequency	Description	References
ApoE-/- mice	Hyperhomocysteinemia-accelerated atherosclerosis model	Oral administration via drinking water	1.8 g/L	8 weeks	To investigate the effects of aerobic exercise and folate supplementation on plasma Hcy level and atherosclerosis development. Results showed that DL-Hcy significantly increased plasma Hcy concentration, while aerobic exercise and folate supplementation reduced Hcy levels and decreased atherosclerotic plaque area.	Acta Cardiol Sin. 2023 Mar;39(2):309-318

H-DL-HoCys-OH/DL-高半胱氨酸实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

7.40mL

1.48mL

0.74mL

36.99mL

7.40mL

3.70mL

73.98mL

14.80mL

7.40mL

H-DL-HoCys-OH/DL-高半胱氨酸技术信息

CAS号	454-29-5
分子式	C₄H₉NO₂S
分子量	135.18
SMILES Code	O=C(O)C(N)CCS
MDL No.	MFCD00004898

别名	2-氨基-4-巯基丁酸 ;NSC 206252; DL-Homocysteine
运输	蓝冰
InChI Key	FFFHZYDWPBMWHY-UHFFFAOYSA-N
Pubchem ID	778

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

溶解方案

细胞实验：

H₂O: 40 mg/mL(295.89 mM)，配合低频超声助溶

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