There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Se-Methylselenocysteine has strong cancer chemopreventive activity and antioxidant activity. Se-Methylselenocysteine is orally active and induces apoptosis[1][2].Acting in the concentration range of 100-400 μM for 3 days, Se-Methylselenocysteine induced caspase-3-mediated apoptosis in SKOV-33 cells, leading to a significant increase in sub-G1 phase accumulation[1][2].
H-3-(Me-Se)-Ala-OH/L-硒甲基硒代半胱氨酸 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Caenorhabditis elegans (C. elegans)
100 μM
18 h
To study the bioavailability, protein incorporation, and modulation of the antioxidant defense system by Se-Methylselenocysteine. Results showed that all tested selenium compounds were bioavailable, but only SeMet persistently accumulated and was non-specifically incorporated into proteins. However, the protection against chemically-induced reactive species formation was independent of the applied selenium compound.
Evaluate the effects of Se-Methylselenocysteine on the growth of HMEC cells. Results showed that MSC at 1500 ng Se/mL did not significantly inhibit the growth of HMEC cells.
Int J Med Sci. 2015 Sep 5;12(9):748-58
MDA-MB-231 cells
1500 ng Se/mL
24, 48, 72, and 96 h
Evaluate the effects of Se-Methylselenocysteine on growth inhibition and apoptosis in MDA-MB-231 cells. Results showed that MSC at 1500 ng Se/mL inhibited the growth of MDA-MB-231 cells, but the effect was lower than MSA.
Int J Med Sci. 2015 Sep 5;12(9):748-58
MCF-7 cells
1500 ng Se/mL
24, 48, 72, and 96 h
Evaluate the effects of Se-Methylselenocysteine on growth inhibition and apoptosis in MCF-7 cells. Results showed that MSC at 1500 ng Se/mL inhibited the growth of MCF-7 cells, but the effect was lower than MSA.
Int J Med Sci. 2015 Sep 5;12(9):748-58
HepG2 cells
1.25~20 µg/mL
24 hours
Evaluate the effect of MSC on glucose consumption in HepG2 cells, results showed MSC (5 µg/mL) significantly increased glucose consumption
Molecules. 2023 Jul 19;28(14):5499
H-3-(Me-Se)-Ala-OH/L-硒甲基硒代半胱氨酸 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Nude mice
786.0 renal cell carcinoma xenograft model
Oral
10 mg/kg
Once daily for 7 days
To evaluate the antitumor activity of MSC in the 786.0 renal cell carcinoma xenograft model, results showed that MSC selectively stabilized tumor vasculature and enhanced the efficacy of subsequent treatments
Int J Mol Sci. 2018 Oct 29;19(11):3378
Caenorhabditis elegans (C. elegans)
Wildtype and txnrd-1 deletion mutants
Hatch incubation
100 μM
Single dose, 18 hours
To evaluate the protective effects of Se-Methylselenocysteine against oxidative stress and its modulation of the antioxidant defense system. Results showed that Se-Methylselenocysteine protected wildtype C. elegans from chemically-induced reactive oxygen and nitrogen species (RONS) formation, but no protective effect was observed in txnrd-1 deletion mutants.
Mol Nutr Food Res. 2019 May;63(9):e1801304
C57BL/6J mice
High-fat diet and streptozotocin-induced type 2 diabetes model
Oral
6.5 or 13 µg/kg MSC
Once daily for four weeks
Evaluate the effect of TAC/MSC on blood glucose and lipid metabolism in type 2 diabetic mice, results showed TAC/MSC significantly improved hyperglycemia and lipid metabolism disorder
Molecules. 2023 Jul 19;28(14):5499
Sprague-Dawley rats
DEN-induced hepatocellular carcinoma rat model
Oral
0.3 mg/kg, 1 mg/kg, 3 mg/kg
5 times per week for 6 consecutive weeks
MSC treatment significantly alleviated liver injury and nuclear lesions, improved liver function, decreased CD34 expression and NO/NOS levels, and suppressed VEGF expression.
Med Sci Monit. 2021 Aug 4;27:e929255
H-3-(Me-Se)-Ala-OH/L-硒甲基硒代半胱氨酸 动物研究
Animal study
Se-Methylselenocysteine, administered orally once daily for 14 days at a dose of 0.2 mg/mouse, potentiated the antitumour activity of CDDP and cyclophosphamide in nude mice bearing human FaDu and A253 head and neck xenografts[2].
搜索
HazMat Fee +
