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细胞生物学 囊泡
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细胞凋亡
细胞周期 细胞骨架 细胞凋亡 蛋白质酪氨酸激酶 帕金森与阿尔茨海默症 细胞死亡
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细胞凋亡诱导剂
驱动蛋白 c-Kit 凋亡
/ Filanesib HCl

Filanesib HCl {[allProObj[0].p_purity_real_show]}

货号：A1152213 同义名： ARRY-520 hydrochloride

Filanesib hydrochloride是一种 Kinesin spindle protein (KSP) 抑制剂，能够干扰细胞分裂。它在癌症治疗中展现出显著的抗增生活性。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Filanesib HCl 化学结构 CAS号：1385020-40-5
Filanesib HCl 化学结构
CAS号：1385020-40-5
Filanesib HCl 3D分子结构
CAS号：1385020-40-5
Filanesib HCl 化学结构 CAS号：1385020-40-5
Filanesib HCl 3D分子结构 CAS号：1385020-40-5
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Filanesib HCl 纯度/质量文件 产品仅供科研

货号：A1152213 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]
更多 >
产品名称 Kinesin ↓ 其他靶点 纯度
SB-743921 HCl ++++

KSP, Ki: 0.07 nM

KSP (P388 cells), IC50: 14.4 nM

 		99%+
GSK-923295 ++

CENP-E, Ki: 3.2 nM

 		99%+
Ispinesib +++

KSP (HsEg5), Ki app: 1.7 nM

 		99%+
AZ3146 +

Mps1, IC50: ~35 nM

 		98+%
MPI-0479605 ++

Mps1, IC50: 1.8 nM

 		99%+
BAY1217389 +++

Mps1, IC50: 0.63 nM

 		98%
ARQ 621 ✔ 98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
产品名称 c-Kit ↓ 其他靶点 纯度
Tyrphostin AG1296 +

c-Kit (Swiss 3T3), IC50: 1.8 μM

 		PDGFR 99%+
Masitinib +

Kit, IC50: 200 nM

 		99%+
Motesanib Diphosphate +++

Kit, IC50: 8 nM

 		97%
Ki8751 ++

c-Kit, IC50: 40 nM

 		99%
Tivozanib ++

c-Kit, IC50: 78 nM

 		99%+
Pazopanib +

c-Kit, IC50: 140 nM

 		99%
Sitravatinib +++

Kit, IC50: 6 nM

 		99%+
Pexidartinib +++

Kit, IC50: 10 nM

 		99%+
Lactate ++++

c-Kit, IC50: 2 nM

 		FLT3 85%
Amuvatinib +++

c-Kit (D816H), IC50: 10 nM

 		99%+
Imatinib Mesylate +

c-Kit, IC50: 100 nM

 		PDGFR 99%
AZD2932 +++

c-Kit, IC50: 9 nM

 		99%
Axitinib ++++

Kit, IC50: 1.7 nM

 		98%
Dovitinib ++++

c-Kit, IC50: 2 nM

 		FLT3 99%+
Sunitinib ✔ FLT3 98%
OSI-930 +

Kit, IC50: 80 nM

 		99%+
Telatinib ++++

c-Kit, IC50: 1 nM

 		99%+
Dasatinib monohydrate ++

c-Kit (wt), IC50: 79 nM

c-Kit (D816V), IC50: 37 nM

 		Src 98%
Dasatinib ++

c-Kit (D816V), IC50: 37 nM

c-Kit (wt), IC50: 79 nM

 		Src 98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Filanesib HCl 细胞实验

Cell Line
Concentration Treated Time Description References
HUH6 10 nM 72 hours Evaluate the effect of Filanesib on HUH6 cell viability; 10 nM Filanesib reduced cell viability by approximately 40% NPJ Precis Oncol. 2025 Apr 25;9(1):122
HB-279 1 nM 72 hours Evaluate the effect of Filanesib on HB-279 cell viability; 1 nM Filanesib reduced ATP concentration by 80% NPJ Precis Oncol. 2025 Apr 25;9(1):122
HB-303 10 nM 72 hours Evaluate the effect of Filanesib on HB-303 cell viability; Filanesib was effective in all models, reducing ATP concentration by at least 30% NPJ Precis Oncol. 2025 Apr 25;9(1):122

Filanesib HCl 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Mice HB PDX models Oral gavage 20 mg/kg Every 4th day for 18 days Evaluate the in vivo effect of Filanesib on HB tumor growth; Filanesib reduced the rate of tumor growth in 4/5 HB PDX models, with HB-279 showing complete growth arrest NPJ Precis Oncol. 2025 Apr 25;9(1):122
CB17-SCID mice Subcutaneous plasmacytoma model Intraperitoneal injection 10 mg/kg Filanesib 2 days per week, pomalidomide 5 days per week, dexamethasone 2 days per week, continuous treatment Evaluate the antimyeloma activity of the triple combination of filanesib with pomalidomide and dexamethasone, showing significant tumor growth delay and improved survival in mice Haematologica. 2017 Dec;102(12):2113-2124

Filanesib HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.19mL

0.44mL

0.22mL

10.94mL

2.19mL

1.09mL

21.88mL

4.38mL

2.19mL

Filanesib HCl 技术信息

CAS号1385020-40-5
分子式C20H23ClF2N4O2S
分子量 456.94
SMILES Code O=C(N1[C@@](C2=CC=CC=C2)(CCCN)SC(C3=CC(F)=CC=C3F)=N1)N(OC)C.[H]Cl
MDL No. MFCD30747801
别名 ARRY-520 hydrochloride
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, 2-8°C

Tags: Filanesib | 1385020-40-5 | ARRY-520 | ARRY520 | ARRY 520 | KSP Inhibitor | Cell Cycle/DNA Damage | Apoptosis | Cytoskeleton | Kinesin | Apoptosis | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Filanesib HCl 纯度/质量文件 | Filanesib HCl 亚型比较 | Filanesib HCl 实验方案 | Filanesib HCl 技术信息

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