Dexamethasone|Prednisolone F; Hexadecadrol; NSC 34521; MK-125|Glucocorticoid Receptor|Autophagy|IL Receptor|for research only|Ambeed

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Dexamethasone/地塞米松 {[allProObj[0].p_purity_real_show]}

货号：A144976 同义名： Prednisolone F; Hexadecadrol

Dexamethasone是一种强效合成糖皮质激素，通过高亲和力结合糖皮质激素受体（GR），诱导SGK1介导的GDI磷酸化，增强Rab蛋白依赖的AMPAR膜转运，调控海马与杏仁核突触可塑性。显著抑制NF-κB通路，阻断促炎因子（TNF-α, IL-6）释放，并抑制树突状细胞分化，发挥超强免疫抑制与抗炎作用（效力为氢化可的松的25倍）。

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Dexamethasone/地塞米松化学结构
CAS号：50-02-2

Dexamethasone/地塞米松 3D分子结构
CAS号：50-02-2

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Dexamethasone/地塞米松纯度/质量文件产品仅供科研

货号：A144976 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]; • Cell, 2025. Ambeed. [ A122167 ]; • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]; • Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]; 更多 >

IL Receptor 亚型比较
自噬亚型比较

产品名称	Glucocorticoid Receptor ↓ ↑	其他靶点	纯度
Dexamethasone	✔		97%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	Autophagy ↓ ↑	其他靶点	纯度
SBI-0206965	+++ ULK1, IC50: 108 nM ULK2, IC50: 711 nM		95%
Hydroxychloroquine sulfate	✔		99%
Valproic acid sodium	✔	HDAC	97%
PFK-015	++ PFKFB3, IC50: 207 nM		99%+
MRT68921 HCl	++++ ULK1, IC50: 2.9 nM ULK2, IC50: 1.1 nM		99%+
ROC-325	✔		99%+
Autophinib	+++ Autophagy, IC50: 40 nM		99%
Lys05	✔		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Dexamethasone/地塞米松生物活性

靶点	Glucocorticoid Receptor
描述	Dexamethasone是一种强效合成糖皮质激素，通过高亲和力结合糖皮质激素受体（GR），诱导SGK1介导的GDI磷酸化，增强Rab蛋白依赖的AMPAR膜转运，调控海马与杏仁核突触可塑性。显著抑制NF-κB通路，阻断促炎因子（TNF-α, IL-6）释放，并抑制树突状细胞分化，发挥超强免疫抑制与抗炎作用（效力为氢化可的松的25倍）。 *该产品仅可用于细胞层面的研究，不可用于动物实验。
体外研究	Dexamethasone通过糖皮质激素受体（GR）依赖性机制，在体外模型中展现出多维度生物效应： ① 免疫抑制方面：在nM浓度级（IC₅₀ ≈ 10⁻⁸ M）显著抑制免疫细胞功能——包括下调巨噬细胞MHC-II表达（>90%抑制TNF-α/IL-6分泌）、阻断树突细胞CD80/CD86共刺激分子（降低50-70%），并诱导CD4⁺ T细胞凋亡（增加3倍）及抑制Th17分化^[1][2]。 ② 抗炎机制：通过抑制NF-κB核转位及p38/JNK磷酸化，阻断炎症介质释放（PGE₂合成IC₅₀=3.2nM，LTB₄抑制率75%）^[1][3]。 ③ 肿瘤调控双重性：在μM浓度诱导多发性骨髓瘤细胞凋亡（48h凋亡率>40%），但抑制乳腺癌细胞迁移（降低60%）及VEGF表达^[3]。 ④ 细胞保护作用：激活PI3K/Akt非基因组通路（<30min），增强上皮屏障蛋白（ZO-1表达上调3倍）并降低氧化应激（ROS减少45%）。关键特征为 GR介导的剂量效应分化（免疫抑制：nM级 vs 促凋亡：μM级），且所有效应可被GR拮抗剂RU486逆转^[1][2]。

Dexamethasone/地塞米松动物实验

Species C57BL/6J mice C57BL/6 mice	Animal Model Fasted for 48 hours or treated with DEX for 5 days Immunocompetent syngeneic mouse model	Administration	Dosage	Frequency	Description	References
C57BL/6J mice	Fasted for 48 hours or treated with DEX for 5 days	Subcutaneous injection	5 mg/kg	Once daily for 5 days	To assess the effects of fasting and DEX treatment on serum uric acid and muscle purine release, results showed both fasting and DEX treatment increased serum uric acid and muscle uric acid release.	JCI Insight. 2024 Jan 23;9(2):e171815
C57BL/6 mice	Immunocompetent syngeneic mouse model	Intraperitoneal injection	5, 50, or 100 μg/kg	Three times a week until day 90	To evaluate the effect of low-dose DEX on ovarian tumor growth and abdominal metastasis, results showed that low-dose DEX significantly inhibited the primary ovarian tumor size and abdominal metastasis	PLoS One. 2017 Jun 7;12(6):e0178937

Dexamethasone/地塞米松细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源
293 MSR cells		Function assay	60 mins	Displacement of [3H]-dexamethasone human glucocorticoid receptor alpha expressed in 293 MSR cells after 60 mins by scintillation counting, EC50=12.5 nM	23199485
african green monkey COS7 cells		Function assay		Agonist activity at glucocorticoid receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by luciferase reporter gene assay, EC50=7.2 nM	19863083
COS7 cells	1 μM	Function assay		Agonist activity at glucocorticoid receptor Q570A mutant in COS7 cells at 1 uM by NF-kappaB-luciferase reporter gene assay	18038970
CV1 cells		Function assay		Activity at human glucocorticoid receptor expressed in CV1 cells assessed as repression of TNF and IL-1-beta-induced E-selectin gene expression by luciferase reporter gene assay, ED50=0.1 nM	18032610

Dexamethasone/地塞米松参考文献

[1]Poulsen RC, Watts AC, Murphy RJ, Snelling SJ, Carr AJ, Hulley PA. Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence. Ann Rheum Dis. 2014 Jul;73(7):1405-13.

[2]Fouty B, Moss T, Solodushko V, Kraft M. Dexamethasone can stimulate G1-S phase transition in human airway fibroblasts in asthma. Eur Respir J. 2006 Jun;27(6):1160-7.

[3]Muhammad W, Zhu J, Zhai Z, Xie J, Zhou J, Feng X, Feng B, Pan Q, Li S, Venkatesan R, Li P, Cao H, Gao C. ROS-responsive polymer nanoparticles with enhanced loading of dexamethasone effectively modulate the lung injury microenvironment. Acta Biomater. 2022 Aug;148:258-270.

Dexamethasone/地塞米松实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.55mL

0.51mL

0.25mL

12.74mL

2.55mL

1.27mL

25.48mL

5.10mL

2.55mL

Dexamethasone/地塞米松技术信息

CAS号	50-02-2
分子式	C₂₂H₂₉FO₅
分子量	392.46
SMILES Code	O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@@]4(C(CO)=O)O)=C1
MDL No.	MFCD00064136

别名	Prednisolone F; Hexadecadrol; NSC 34521; MK-125
运输	蓝冰
InChI Key	UREBDLICKHMUKA-CXSFZGCWSA-N
Pubchem ID	5743

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, 2-8°C

溶解方案

细胞实验：

DMSO: 250 mg/mL(637.01 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 8 mg/mL(20.38 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

方案三

方案四

配制的工作液建议现用现配，短期内尽快用完。以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源

293 MSR cells		Function assay	60 mins	Displacement of [3H]-dexamethasone human glucocorticoid receptor alpha expressed in 293 MSR cells after 60 mins by scintillation counting, EC50=12.5 nM	23199485
african green monkey COS7 cells		Function assay		Agonist activity at glucocorticoid receptor ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by luciferase reporter gene assay, EC50=7.2 nM	19863083
COS7 cells	1 μM	Function assay		Agonist activity at glucocorticoid receptor Q570A mutant in COS7 cells at 1 uM by NF-kappaB-luciferase reporter gene assay	18038970
CV1 cells		Function assay		Activity at human glucocorticoid receptor expressed in CV1 cells assessed as repression of TNF and IL-1-beta-induced E-selectin gene expression by luciferase reporter gene assay, ED50=0.1 nM	18032610
HEK293 cells		Function assay		Displacement of [3H]-aldosterone from human mineralocorticoid receptor expressed in HEK293 cells, Ki=0.36 nM	24446728
HFF cells		Function assay		Antiinflammatory activity assessed as inhibition of IL1 stimulated IL6 production in HFF cells by transrepression assay, EC50=0.5 nM	17692519
human 13D3/Huh7 cells		Function assay	24 h	Transactivation activity at glucocorticoid receptor in human 13D3/Huh7 cells assessed as induction of tyrosine aminotransferase activity after 24 hrs, EC50=5 nM	21073190
human A549 cells		Function assay		Activity at glucocorticoid receptor in human A549 cells assessed as effect on GRE promoter response by luciferase reporter assay, EC50=1 nM	16643060
human H13 cells		Function assay		Inhibition of glucocorticoid receptor in human H13 cells assessed as inhibition of glucocorticoid-induced cell proliferation after 3 hrs by [3H]-thymidine incorporation assay, EC50=9.7 nM	23199485
human HeLa cells		Function assay		Transrepression activity at glucocorticoid receptor-mediated antiinflammatory activity in human HeLa cells assessed as inhibition of TPA-induced collagenase promoter activity by luciferase reporter gene assay, IC50=1.58 nM	20727743
human HeLa cells		Function assay		Transactivation of GR-LBD expressed in human HeLa cells co-expressing GAL4-DBD by luciferase reporter gene assay, EC50=4.2 nM	24011644
human HeLaS3 cells		Function assay	2 h	Displacement of [3H]Dexamethasone from glucocorticoid receptor in human HeLaS3 cells after 2 hrs	23403082
human HepG2 cells		Function assay	24 h	Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis, EC50=2.6 μM	20966043
human HMC1 cells		Function assay	1 h	mmunomodulatory activity in human HMC1 cells assessed as inhibition of phorbol 12-myristate 13-acetate/A23187-stimulated IL1-beta secretion treated 1 hr prior to 30 mins phorbol 12-myristate 13-acetate/A23187 challenge by Western blotting analysis	21302967
human MDA-kb2 cells		Function assay		Agonist activity at androgen receptor in human MDA-kb2 cells assessed as stimulation of luciferase activity by luciferase reporter gene assay	19592245
human monocytes	5 μM	Function assay	20 h	Antiinflammatory activity in human monocytes assessed as inhibition of LPS-induced COX2 expression at 5 uM after 20 hrs using rabbit polyclonal antibody IgG by SDS-PAGE analysis	21843935
human NP1 cells		Function assay		Agonist activity at GR ligand binding domain expressed in human NP1 cells assessed as glucocorticoid response element transactivation by GAL4 luciferase reporter gene assay, EC50=4.2 nM	19321341
human PBMC		Function assay		Antiinflammatory activity in human PBMC assessed as inhibition of anti-CD3-induced GM-CSF production after 48 hrs, EC50=0.47 nM	23199485
human PBMC		Function assay	24 h	Antiinflammatory activity in human PBMC assessed as inhibition of PHA-induced IFNgamma production after 24 hrs	23199485
human RPMI8226 cells		Proliferation assay	4 days	Antiproliferative activity against human RPMI8226 cells after 4 days, IC50=6.5 nM	17705362
human SW1353 cells		Function assay		Transrepression activity at glucocorticoid receptor in human SW1353 cells assessed as repression of IL-1-induced MMP-13 production after 24 hrs by ELISA, IC50=1.8 nM	25706100
human THP1 cells		Function assay		Transrepression activity at glucocorticoid receptor-mediated antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced IL-8 production, IC50=2.51 nM	20727743
human U2OS cells		Function assay	18 h	Agonist activity at glucocorticoid receptor-LBD in human U2OS cells transfected with Gal4-DBD assessed as increase of transactivation activity after 18 hrs by luciferase reporter gene assay, EC50=15.8489 μM	20812681
mouse J774A.1 cells		Function assay		Inhibition of LPS-induced TNFalpha production in mouse J774A.1 cells, IC50=48 nM	17892941
mouse RAW264.7 cells		Function assay	18 h	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha secretion after 18 hrs, IC50=0.01 μM	21353543
mouse thymocytes	1 μM	Function assay	24 h	Induction of apoptosis in mouse thymocytes assessed as internucleosomal DNA fragmentation at 1 uM after 24 hrs by agarose gel electrophoresis	24794748
NHDFneo cells		Function assay		Activity at human GR expressed in NHDFneo cells assessed as inhibition of IL-6 production, IC50=1.4 nM	17705362
rat polymorphonuclear leukocytes		Function assay	20 mins	Antiinflammatory activity in rat polymorphonuclear leukocytes assessed as inhibition of LPS-stimulated nitric oxide production after 20 mins by Griess method, IC50=2.3 nM	22506620
rat R1 cells	10 μM	Function assay	24 h	Inhibition of glucocorticoid receptor-glucocorticoid complex transfected in rat R1 cells assessed as down-regulation of TPA-responsive element proinflammatory gene expression at 10 uM after 24 hrs by beta-galactosidase assay, IC50=5 nM	18412397
RAW 264.7 cells		Function assay	24 h	Inhibition of interferon gamma-stimulated NO production in RAW 264.7 cells after 24 hrs, IC50=0.02 μM	17367124
Sf9 cells		Function assay		Binding affinity to human recombinant glucocorticoid receptor expressed in baculovirus infected Sf9 cells	20727743

Dexamethasone/地塞米松 {[allProObj[0].p_purity_real_show]}

Dexamethasone/地塞米松纯度/质量文件产品仅供科研

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Dexamethasone/地塞米松质控信息

Dexamethasone/地塞米松生物活性

Dexamethasone/地塞米松动物实验

Dexamethasone/地塞米松细胞研究

Dexamethasone/地塞米松参考文献

Dexamethasone/地塞米松实验方案

Dexamethasone/地塞米松技术信息

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全球学术期刊中引用的产品

Dexamethasone/地塞米松 质控信息

Dexamethasone/地塞米松 生物活性

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Dexamethasone/地塞米松纯度/质量文件产品仅供科研

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Dexamethasone/地塞米松参考文献

Dexamethasone/地塞米松实验方案

Dexamethasone/地塞米松技术信息