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/ Crocetin/藏红花酸

Crocetin/藏红花酸 {[allProObj[0].p_purity_real_show]}

货号：A146082 同义名： 藏红花 / Transcrocetin; NSC 407300

Crocetin是藏红花衍生物，能抑制人乳酸脱氢酶 5，并作为抗糖酵解的抗癌方法。

Crocetin/藏红花酸 化学结构 CAS号：27876-94-4
Crocetin/藏红花酸 化学结构
CAS号：27876-94-4
Crocetin/藏红花酸 3D分子结构
CAS号：27876-94-4
Crocetin/藏红花酸 化学结构 CAS号：27876-94-4
Crocetin/藏红花酸 3D分子结构 CAS号：27876-94-4
规格 价格 会员价 库存 数量
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Crocetin/藏红花酸 纯度/质量文件 产品仅供科研

货号：A146082 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Dehydrogenase ↓ 其他靶点 纯度
Trilostane ✔ 99+%
AGI-6780 +++

IDH2 R140Q mutant, IC50: 23 nM

 		99%+
Gimeracil ✔ 98%
AGI-5198 ++

R132H-IDH1, IC50: 70 nM

R132C-IDH1, IC50: 0.16 μM

 		99%+
SW033291 ++++

15-PGDH, IC50: 1.5 nM

15-PGDH, Ki: 0.1 nM

 		99%+
Mycophenolic acid ✔ 99+%
Fomepizole ✔ 98%
Leflunomide ✔ 98%
3-Nitropropanoic acid ✔ 99%+
Isovaleramide ✔ 99%
Mycophenolate Mofetil +++

Inosine monophosphate dehydrogenase I, IC50: 39 nM

Inosine monophosphate dehydrogenase II, IC50: 27 nM

 		98%
MK-8245 ++++

SCD1 (mouse), IC50: 1 nM

SCD1 (rat), IC50: 3 nM

 		99%+
Vidofludimus ++

Human DHODH, IC50: 134 nM

 		99%+
Emodin ✔ 98%
Ivosidenib ✔ 98%
NCT-501 ++

ALDH1A1, IC50: 40 nM

 		98%
Gossypol ✔ 99%+
Devimistat ✔ 98%
Disulfiram ✔ 98%+
Enasidenib ++++

IDH2, IC50: 12 nM

 		98%
PluriSIn 1 ✔ 99%+
ML390 +

DHODH, IC50: 0.56 μM

 		99%+
Teriflunomide ✔ 99%+
Daidzin +++

ALDH-Ⅰ, Ki: 20 nM

 		98+%
18β-Glycyrrhetinic acid ✔ 99%
RRx-001 ✔ 95%
NCT-503 +

PHGDH, IC50: 2.5 μM

 		99%+
Vorasidenib ✔ 99%+
Ammonium Glycyrrhizinate(x:1) ✔ 98+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Crocetin/藏红花酸 生物活性

描述 Crocetin is an active constituent of saffron (Crocus sativus L.) stigma and exhibits various health-promoting properties including anti-tumor, neuroprotective effects, anti-diabetics, anti-inflammatory, anti-hyperlipidemia, etc[3]. Crocetin could be suggested as a potential dermatological whitening agent in skin care products. Decreased tyrosinase activity, melanin content, tyrosinase and MITF (Microphthalmia-Associated Transcription Factor) proteins levels, and ROS (Reactive Oxygen Species) production showed the inhibition of melanogenesis in B16F10 cells by crocetin[4]. Human Umbilical Vein Endothelial Cells (HUVECs) were incubated with various concentrations of Crocetin (1, 5, 25, 50, and 100 µM) over a period of 72 h. Protein level of VEGFR-1, -2 and p-Akt/Akt, p-eNOS/eNOS ratios were increased 72 h after the treatment of HUVECs with Crocetin. Crocetin promotes HUVECs angiogenesis potential by the modulation of VEGF signaling pathway and increased cell viability[5]. Crocetin significantly inhibited the proliferation of KYSE-150 cells in a dose- and time-dependent manner. Crocetin also markedly induced cell apoptosis. Furthermore, we have found that crocetin not only inhibited the activation of PI3K/AKT, extracellular signal-regulated kinase-1/2 (ERK1/2), and p38 but also upregulated the p53/p21 levelhttps://pubmed.ncbi.nlm.nih.gov/30783055.

Crocetin/藏红花酸 细胞实验

Cell Line
Concentration Treated Time Description References
Primary neuronal cells 25 µM 12 hours Induced autophagy, increased LC3B-II levels, reduced SQSTM1 expression Autophagy. 2021 Nov;17(11):3813-3832.
N9 microglial cells 3.12 to 50 µM 12 hours Induced autophagy, increased LC3B-II levels, reduced SQSTM1 expression Autophagy. 2021 Nov;17(11):3813-3832.

Crocetin/藏红花酸 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
C57BL/6 mice Wild-type mice Oral gavage 5, 10 and 20 mg/kg Once daily for 30 days Induced autophagy, increased expression of autophagy-related protein markers Autophagy. 2021 Nov;17(11):3813-3832.

Crocetin/藏红花酸 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01278277 Retinal Degeneration ... 展开 >> Genetic Disease Single-Gene Defects Macular Dystrophy 收起 << Phase 1 Phase 2 Active, not recruiting December 2017 Italy ... 展开 >> Policlinico A. Gemelli Rome, Italy, 00168 收起 <<

Crocetin/藏红花酸 参考文献

[1]Berger F, Hensel A, Nieber K. Saffron extract and trans-crocetin inhibit glutamatergic synaptic transmission in rat cortical brain slices. Neuroscience. 2011 Apr 28;180:238-47.

[2]Dufresne C, Cormier F, Dorion S. In vitro formation of crocetin glucosyl esters by Crocus sativus callus extract. Planta Med. 1997 Apr;63(2):150-3.

[3]Hashemi M, Hosseinzadeh H. A comprehensive review on biological activities and toxicology of crocetin. Food Chem Toxicol. 2019 Aug;130:44-60

[4]Hashemi-Shahri SH, Golshan A, Mohajeri SA, Baharara J, Amini E, Salek F, Sahebkar A, Tayarani-Najaran Z. ROS-scavenging and Anti-tyrosinase Properties of Crocetin on B16F10 Murine Melanoma Cells. Anticancer Agents Med Chem. 2018;18(7):1064-1069

[5]Nasirzadeh M, Rasmi Y, Rahbarghazi R, Kheradmand F, Karimipour M, Aramwit P, Astinfeshan M, Gholinejad Z, Daeihasani B, Saboory E, Shirpoor A, Rezabakhsh A, Zolali E, Khalaji N. Crocetin promotes angiogenesis in human endothelial cells through PI3K-Akt-eNOS signaling pathway. EXCLI J. 2019 Oct 21;18:936-949

Crocetin/藏红花酸 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.05mL

0.61mL

0.30mL

15.23mL

3.05mL

1.52mL

30.45mL

6.09mL

3.05mL

Crocetin/藏红花酸 技术信息

CAS号27876-94-4
分子式C20H24O4
分子量 328.4
SMILES Code O=C(O)/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C(O)=O
MDL No. MFCD00017359
别名 藏红花 ;Transcrocetin; NSC 407300; trans-Crocetin
运输蓝冰
InChI Key PANKHBYNKQNAHN-MQQNZMFNSA-N
Pubchem ID 5281232
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, store in freezer, under -20°C
溶解方案

DMSO: 1 mg/mL(3.05 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案 一

Tags: Crocetin | 27876-94-4 | Transcrocetin | trans-Crocetin | Membrane Transporter/Ion Channel | Neuronal Signaling | Metabolic Enzyme/Protease | iGluR | Endogenous Metabolite | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Crocetin/藏红花酸 纯度/质量文件 | Crocetin/藏红花酸 亚型比较 | Crocetin/藏红花酸 生物活性 | Crocetin/藏红花酸 临床数据 | Crocetin/藏红花酸 参考文献 | Crocetin/藏红花酸 实验方案 | Crocetin/藏红花酸 技术信息

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