Anastrozole is a potent, highly selectivearomatase inhibitor, which inhibits human placentalaromatase with an IC50 of 15 nM.
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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Aromatase is the only enzyme in vertebrates known to catalyse the biosynthesis of all oestrogens from androgens[3]. Anastrozole as an achiral triazole derivative is an aromatase inhibitor with IC50 value of 15 nM. Anastrozole has been shown to possess superior efficacy and tolerability over established endocrine agents in advanced breast cancer[4]. In vitro, anastrozole markedly inhibited breast cancer cell line MCF-7 cell proliferation at concentration ranging in 15 – 80 nM[5]. Administration of 1 μM anastrozole for 24h reduced mouse mammary carcinoma derived FM3A cell viability[6]. Treatment with 200 mg/mL and 300 mg/mL anastrozole significantly inhibited the growth of endometrioma cells and estradiol secretion[7]. In vivo, treatment with anastrozole on the dose of 200 μg/kg once a day established to be maximally effective in reducing tumor growth in the mouse intratumoral aromatase xenograph model[8]. Administration of 0.1 mg/kg anastrozole completely blocked ovulation and extinguished the uterotrophic activity of exogenous androstenedione in immature rats[9]. Treatment with anastrozole 1 or 10 mg reduced the percentage aromatization from 2.25% to 0.074% and 0.043% in post-menopausal women with a diagnosis of advanced or recurrent[10].
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