Acteoside | 麦角甾苷 | Kusaginin | Bacterial Inhibitor

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Acteoside/类叶升麻苷 {[allProObj[0].p_purity_real_show]}

货号：A119193 同义名： 麦角甾苷;毛蕊花苷 / Kusaginin; TJC160

Acteoside是从Cistanche deserticola Y.C. Ma植物中分离提取的天然产物，具有抗氧化作用，且为PKC抑制剂（IC50 = 25 μM）。

Acteoside/类叶升麻苷化学结构
CAS号：61276-17-3

Acteoside/类叶升麻苷 3D分子结构
CAS号：61276-17-3

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Acteoside/类叶升麻苷纯度/质量文件产品仅供科研

货号：A119193 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]; • Cell, 2025. Ambeed. [ A122167 ]; • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]; • Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]; 更多 >

PKC 亚型比较
转化生长因子-β 亚型比较

产品名称	PKC ↓ ↑	PKCα ↓ ↑	PKCβ ↓ ↑	PKCγ ↓ ↑	PKCδ ↓ ↑	PKCε ↓ ↑	PKCζ ↓ ↑	PKCη ↓ ↑	PKCθ ↓ ↑	其他靶点	纯度
Daphnetin	+ PKC, IC50: 25.01 μM									EGFR,PKA	95%
Dequalinium Chloride											99%+
Quercetin	✔									Sirtuin,Src	95%
Myricetrin		✔									96%
Go 6983		+++ PKCα, IC50: 7 nM	+++ PKCβ, IC50: 7 nM	+++ PKCγ, IC50: 6 nM	+++ PKCδ, IC50: 10 nM		++ PKCζ, IC50: 60 nM				99%+
Go6976	+++ PKC, IC50: 7.9 nM	++++ PKCα, IC50: 2.3 nM	+++ PKCβ1, IC50: 6.2 nM							FLT3	99%+
Bisindolylmaleimide I		+++ PKCα, IC50: 20 nM	+++ PKCβ2, IC50: 16 nM PKCβ1, IC50: 17 nM	+++ PKCγ, IC50: 20 nM							99%+
Lawsone methyl ether			✔								99%
Sotrastaurin		++++ PKCα, Ki: 0.95 nM	++++ PKCβ1, Ki: 0.64 nM		++++ PKCδ, Ki: 2.1 nM	++++ PKCε, Ki: 3.2 nM		++++ PKCη, Ki: 1.8 nM	++++ PKCθ, Ki: 0.22 nM		99%+
Enzastaurin		++ PKCα, IC50: 39 nM	+++ PKCβ, IC50: 6 nM	+ PKCγ, IC50: 83 nM		+ PKCε, IC50: 110 nM					98%
Midostaurin		++ PKCα, IC50: 22 nM	++ PKCβ2, IC50: 31 nM PKCβ1, IC50: 30 nM	++ PKCγ, IC50: 24 nM	+ PKCδ, IC50: 330 nM	+ PKCε, IC50: 1.25 μM		+ PKCη, IC50: 160 nM			99%
Ro 31-8220 mesylate		++++ PKCα, IC50: 5 nM	+++ PKCβ2, IC50: 14 nM PKCβ1, IC50: 24 nM	++ PKCγ, IC50: 27 nM		++ PKCε, IC50: 24 nM					99%+
Staurosporine		++++ PKCα, IC50: 2 nM		++++ PKCγ, IC50: 5 nM	+++ PKCδ, IC50: 20 nM	++ PKCε, IC50: 73 nM		++++ PKCη, IC50: 4 nM			99%+
Ruboxistaurin HCl		+ PKCα, IC50: 0.36 μM	++++ PKCβ2, IC50: 5.9 nM PKCβ1, IC50: 4.7 nM	+ PKCγ, IC50: 0.3 μM	+ PKCδ, IC50: 0.25 μM			++ PKCη, IC50: 0.052 μM			99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	ALK1 ↓ ↑	ALK2 ↓ ↑	ALK3 ↓ ↑	ALK4 ↓ ↑	ALK6 ↓ ↑	Smad3 ↓ ↑	TGF-β ↓ ↑	TGFβRI/ALK5 ↓ ↑	TGFβRII ↓ ↑	纯度
LDN193189	++++ ALK1, IC50: 0.8 nM	++++ ALK2, IC50: 0.8 nM	+++ ALK3, IC50: 5.3 nM		+++ ALK6, IC50: 16.7 nM					99%+
LDN-212854	++++ ALK1, IC50: 2.4 nM	++++ ALK2, IC50: 1.3 nM	+ ALK3, IC50: 85.8 nM	+ ALK4, IC50: 2133 nM				+ ALK5, IC50: 9276 nM		99%+
ML347	++ ALK1, IC50: 46 nM	++ ALK2, IC50: 32 nM								98%
K02288	++++ ALK1, IC50: 1.8 nM	++++ ALK2, IC50: 1.1 nM	++ ALK3, IC50: 34.4 nM		+++ ALK6, IC50: 6.4 nM					99%+
LDN-193189 2HCl	++++ ALK1, IC50: 0.8 nM	++++ ALK2, IC50: 0.8 nM	+++ ALK3, IC50: 5.3 nM		+++ ALK6, IC50: 16.7 nM					99%
LDN-214117		++ ALK2, IC50: 24 nM								98%
DMH-1		+ ALK2, IC50: 107.9 nM								99%+
SB-505124				+ ALK4, IC50: 129 nM				++ ALK5, IC50: 47 nM		99%+
Vactosertib				+++ ALK4, IC50: 13 nM				+++ ALK5, IC50: 11 nM		99%+
Alantolactone						✔				98%
(E/Z)-SIS3 free base						✔				97%
Pirfenidone							✔			98%
Hesperetin							✔			97%
RepSox								++++ TGFβR1(ALK5), IC50: 4 nM		98%
GW788388								+++ ALK5, IC50: 18 nM		98%
LY364947								++ TGFβRI, IC50: 59 nM	+ TGFβRII, IC50: 0.4 μM	98%
SD-208								++ TGF-βRI (ALK5), IC50: 48 nM		99%
SB-525334								+++ TGFβR1(ALK5), IC50: 14.3 nM		99%+
LY2109761								++ TβRI, Ki: 38 nM	+ TβRII, Ki: 300 nM	99%+
Galunisertib								++ TβRI, IC50: 56 nM		98%
SB 431542								+ ALK5, IC50: 94 nM		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Acteoside/类叶升麻苷生物活性

描述

Acteoside (Verbascoside) is isolated from Lantana camara, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity^[3]. Acteoside inhibited cell proliferation, colony formation and migration in all the three human HCC cell lines BEL7404, HLF and JHH-7. The prohibition of angiogenesis by acteoside was revealed by the inhibition of tube formation and cell migration of HUVECs^[4]. ACT (Acteoside) has the potential therapeutic effect on OA (Osteoarthritis) through inhibiting the inflammatory responses via inactivating JAK/STAT signaling pathway^[5]. Acteoside can alleviate mesangial cell inflammatory injury by modulating Th22 lymphocytes chemotaxis and proliferation^[6]. In addition, acteoside could penetrate BBB (blood-brain-barrier) and have potential therapeutic value for PD (Parkinson's disease) by activating the Nrf2/ARE signaling pathway and attenuating the oxidative stress^[7].

Acteoside/类叶升麻苷细胞实验

Cell Line C5N cells A5 cells RAW 264.7 cell line Hepatocytes (BRL-3A) Liver sinusoidal endothelial cells (LSECs)	Concentration	Treated Time	Description	References
C5N cells	500 μM	24 h	Acteoside showed lower toxicity in C5N cells but increased cellular ROS levels.	Redox Biol. 2018 Jun;16:169-178
A5 cells	500 μM	24 h	Acteoside showed increased toxicity in A5 cells, elevated cellular ROS levels, and suppressed MMP-2 and MMP-9 enzymatic activities.	Redox Biol. 2018 Jun;16:169-178
RAW 264.7 cell line	50 µM	24 h	Evaluate the inhibitory effect of Acteoside on macrophage activation, showing significant inhibition of IL-6 secretion at 50 μmol/L.	Engineering (Beijing). 2023 Jan;20:63-76.
Hepatocytes (BRL-3A)	25, 50, 100 μM	16 h	To investigate the effect of Acteoside on HR-induced hepatocyte injury. Results showed that Acteoside reduced the release of injury markers (e.g., HMGB1) from hepatocytes under HR conditions.	Int J Biol Sci. 2023 Sep 18;19(15):4967-4988
Liver sinusoidal endothelial cells (LSECs)	25, 50, 100 μM	12 h	To evaluate the effect of Acteoside on hypoxia-reoxygenation (HR)-induced senescent phenotype in LSECs. Results showed that Acteoside significantly inhibited the upregulation of senescence markers (e.g., p21, p53) and restored the expression of cell cycle checkpoints (e.g., cdk2, ccnd1).	Int J Biol Sci. 2023 Sep 18;19(15):4967-4988

Acteoside/类叶升麻苷动物实验

Species Mice	Animal Model Hepatic ischemia-reperfusion injury (HIRI) model	Administration	Dosage	Frequency	Description	References
Mice	Hepatic ischemia-reperfusion injury (HIRI) model	Oral gavage	25, 50, 100 mg/kg	Once daily for 7 days	To evaluate the protective effect of Acteoside on liver injury in HIRI mice. Results showed that Acteoside significantly ameliorated HIRI-induced liver histopathological injury, abnormal liver function indicators, and senescent phenotype of LSECs.	Int J Biol Sci. 2023 Sep 18;19(15):4967-4988

Acteoside/类叶升麻苷临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03641248	Osteoarthritis, Knee	Early Phase 1	Not yet recruiting	June 2019	United States, Missouri ... 展开 >> Univ of Missouri Health Care Center Not yet recruiting Columbia, Missouri, United States, 65211 Contact: Dean Hainsworth, MD 573-882-4894 ClinicalResearch@health.missouri.edu 收起 <<
NCT02662283	IGA Nephropathy	Phase 2 Phase 3	Unknown	November 2016	China, Guangdong ... 展开 >> Department of Nephrology, 6th Affiliated Hospital, Sun Yat-Sen University Guangzhou, Guangdong, China, 510655 收起 <<

Acteoside/类叶升麻苷参考文献

[1]Santoro A, Bianco G, et al. Verminoside- and verbascoside-induced genotoxicity on human lymphocytes: involvement of PARP-1 and p53 proteins. Toxicol Lett. 2008 May 5;178(2):71-6.

[2]Herbert JM, Maffrand JP, et al. Verbascoside isolated from Lantana camara, an inhibitor of protein kinase C. J Nat Prod. 1991 Nov-Dec;54(6):1595-600.

[3]Herbert JM, Maffrand JP, Taoubi K, Augereau JM, Fouraste I, Gleye J. Verbascoside isolated from Lantana camara, an inhibitor of protein kinase C. J Nat Prod. 1991 Nov-Dec;54(6):1595-600

[4]Ma D, Wang J, Liu L, Chen M, Wang Z. Acteoside as a potential therapeutic option for primary hepatocellular carcinoma: a preclinical study. BMC Cancer. 2020 Sep 29;20(1):936

[5]Qiao Z, Tang J, Wu W, Tang J, Liu M. Acteoside inhibits inflammatory response via JAK/STAT signaling pathway in osteoarthritic rats. BMC Complement Altern Med. 2019 Oct 7;19(1):264

[6]Gan L, Li X, Zhu M, Chen C, Luo H, Zhou Q. Acteoside relieves mesangial cell injury by regulating Th22 cell chemotaxis and proliferation in IgA nephropathy. Ren Fail. 2018 Nov;40(1):364-370

[7]Li M, Zhou F, Xu T, Song H, Lu B. Acteoside protects against 6-OHDA-induced dopaminergic neuron damage via Nrf2-ARE signaling pathway. Food Chem Toxicol. 2018 Sep;119:6-13

Acteoside/类叶升麻苷实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.60mL

0.32mL

0.16mL

8.01mL

1.60mL

0.80mL

16.01mL

3.20mL

1.60mL

Acteoside/类叶升麻苷技术信息

CAS号	61276-17-3
分子式	C₂₉H₃₆O₁₅
分子量	624.59
SMILES Code	O=C(O[C@@H]1[C@@H](CO)O[C@@H](OCCC2=CC=C(O)C(O)=C2)[C@H](O)[C@H]1O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)/C=C/C4=CC=C(O)C(O)=C4
MDL No.	MFCD00221751

别名	麦角甾苷;毛蕊花苷;毛蕊花糖苷 ;Kusaginin; TJC160; Acetoside; NSC 603831; Verbascoside
运输	蓝冰

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, room temperature

溶解方案

细胞实验：

DMSO: 105 mg/mL(168.11 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 100 mg/mL(160.11 mM)

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

方案三

Acteoside/类叶升麻苷 {[allProObj[0].p_purity_real_show]}

Acteoside/类叶升麻苷纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Acteoside/类叶升麻苷质控信息

Acteoside/类叶升麻苷生物活性

Acteoside/类叶升麻苷细胞实验

Acteoside/类叶升麻苷动物实验

Acteoside/类叶升麻苷临床研究

Acteoside/类叶升麻苷参考文献

Acteoside/类叶升麻苷实验方案

Acteoside/类叶升麻苷技术信息

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Acteoside/类叶升麻苷纯度/质量文件产品仅供科研

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Acteoside/类叶升麻苷生物活性

Acteoside/类叶升麻苷细胞实验

Acteoside/类叶升麻苷动物实验

Acteoside/类叶升麻苷临床研究

Acteoside/类叶升麻苷参考文献

Acteoside/类叶升麻苷实验方案

Acteoside/类叶升麻苷技术信息