γ-Linolenic acid, an unsaturated fatty acid synthesized from linoleic acid (LA) by the enzyme delta-6-desaturase, inhibits inflammatory responses through inactivation of NFκB and activator protein-1 by suppressed oxidative stress.
γ-Linolenic Acid/γ-亚麻酸 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Wistar rats
DEN-induced hepatocellular carcinoma
Oral
0.125, 0.25, and 0.5 mL/kg
Continued for 22 weeks
To investigate the chemoprotective effect of GLA against DEN-induced HCC, results showed that GLA significantly reduced hepatic nodule formation, improved antioxidant status, and exerted protective effects by regulating mitochondrial-mediated apoptosis pathways and anti-inflammatory pathways.
Drug Des Devel Ther. 2018 Dec 13;12:4241-4252
Wistar rats
C6 glioma model
Oral gavage
1 mL/rat/day
Once daily for three weeks
To investigate the effects of oral feeding of oils containing high concentration of GLA, DHA or linoleic acid on blood and tumor total fatty acid composition in rat C6 glioma model. Results showed that DHA oil supplementation increased EPA content in brain tumors and decreased the ratio of n-6/n-3 fatty acids. GLA oil supplementation increased serum GLA concentration but had no significant effect on tumor GLA or DGLA concentrations.
Lipids Health Dis. 2008 Nov 16;7:45
Sprague-Dawley rats
Accelerated ageing model (induced by D-fructose)
Intraperitoneal injection
1, 5 or 15 mg/kg
Once daily for 40 days
To assess the effect of GLA on fructose-induced memory impairment. Results showed that GLA at the lowest tested dose (1 mg/kg) significantly reversed the negative effects of fructose on learning and memory and reduced glycated hemoglobin (HbA1c) levels.
Pharm Biol. 2017 Dec;55(1):1817-1823
Female C57BL/6J mice
Lethal radiation model
Intraperitoneal injection
100 μg/kg
Administered at 48, 24, and 1 h prior to radiation, monitored for 30 days
To evaluate the protective effect of γ-Linolenic Acid against lethal radiation, results showed that γ-Linolenic Acid significantly improved the survival rate of mice to approximately 80%.
Biomolecules. 2022 Jun 7;12(6):797
Human
Patients with atopic dermatitis
Oral
4–6 g daily
Once daily for 12 weeks
To evaluate the clinical improvement of AD patients with EPO supplementation, results showed significant increase in plasma GLA and DGLA levels and significant decrease in SCORAD index
Adv Ther. 2014 Feb;31(2):180-8
Nude mice
HCA-7/C29 xenograft tumor model
Oral gavage
8 mg/mouse
Twice a week for four weeks
Inhibited tumor growth and promoted 8-hydroxyoctanoic acid production
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