γ-Linolenic Acid

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Chemical Structure| 506-26-3 同义名 : C18:3(all cis-6,9,12)Fatty acid; Octadecatrienoic acid(all cis-6,9,12); Gamolenic acid; Gamma-Linolenic acid
CAS号 : 506-26-3
货号 : A106708
分子式 : C18H30O2
纯度 : 98%
分子量 : 278.43
MDL号 : MFCD00065718
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(377.12 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 γ-Linolenic acid, an unsaturated fatty acid synthesized from linoleic acid (LA) by the enzyme delta-6-desaturase, inhibits inflammatory responses through inactivation of NFκB and activator protein-1 by suppressed oxidative stress.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.59mL

0.72mL

0.36mL

17.96mL

3.59mL

1.80mL

35.92mL

7.18mL

3.59mL
参考文献

[1]van der Merwe CF, Booyens J, et al. The effect of gamma-linolenic acid, an in vitro cytostatic substance contained in evening primrose oil, on primary liver cancer. A double-blind placebo controlled trial. Prostaglandins Leukot Essent Fatty Acids. 1990 Jul;40(3):199-202.

[2]Fujiwara F, Todo S, Imashuku S. Antitumor effect of gamma-linolenic acid on cultured human neuroblastoma cells. Prostaglandins Leukot Med. 1986 Aug;23(2-3):311-20.