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货号 产品名 纯度
A375623 Fexaramine

Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity relative to natural compounds.

99%+
A708662 Tropifexor

Tropifexor is a potent agonist of FXR with EC50 of 0.26 nM.

99%+
A1145754 Cilofexor

Cilofexor (GS-9674) 是一种有效的,选择性的,口服活性的非甾体 FXR 激动剂,EC50 为 43 nM。。在一项为期 12 周的研究中,Cilofexor 在原发性硬化性胆管炎患者中耐受良好,并显著改善了肝生化指标和胆汁淤积标志物。

99%+
A387805 Obeticholic Acid/奥贝胆酸

Obeticholic acid is a selective FXR agonist with EC50 of 99 nM and it has anticholestatic activity.

98%
A1281092 Vonafexor

Vonafexor is a farnesoid X receptor agonist.

99%+
A1142872 LY2562175

LY2562175 是一种高效且选择性的 FXR 激动剂,其 EC50 值为 193 nM。

99%
A1144321 (Z)-Guggulsterone/孕二烯二酮

(Z)-Guggulsterone is a broad spectrum steroid receptor ligand and an antagonist of FXR with antiseptic, antirheumatic and anti-inflammatory activity in vivo.

98+%
A170958 GW 4064

GW4064 is a selective, non-steroidal farnesoid X receptor (FXR) agonist (EC50 = 15 nM).

99%+
A467377 T0901317

T0901317 is a selective agonist for LXR and FXR with EC50 of 50 nM and 5 μM, respectively.

99%+
A818184 DY268

99%+
A615253 Nidufexor

Nidufexor is a potent farnesoid X receptor (FXR) agonist for the treatment of non-alcoholic steatohepatitis (NASH) and hepatobiliary disorders.

99%+
A1229813 Guggulsterone/香胶甾酮

Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 μM for Z- and E-Guggulsterone, respectively.

98%
A1249681 NDB

98%
A1250510 NR1H4 activator 1

A1340340 Glyco-Obeticholic acid

99%
A1483401 GSK2324

98%
A1682386 FXR antagonist 1

98%
A1723042 Alismanol M

98%
A1964206 HEC96719

98%
A626428 Fargesone A

Fargesone A is a natural product isolated and purified from the flower of Magnolia fargesii, shows inhibitory effects on nitric oxide (NO) production in the lipopolysaccharide plus interferon-gamma activated-murine macrophage cell line, J774.1.

98+%
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