There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Guggulsterone is a phytosterol extracted from the gum resin of the Commiphora wightii tree. Guggulsterone inhibits the growth of many tumour cells. It induces apoptosis by down-regulating anti-apoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP, and survivin), regulating cell cycle proteins (cyclin D1 and c-Myc), activating caspases and JNK, and inhibiting Akt[1].Guggulsterone acts as an FXR antagonist and reduces CDCA-induced FXR activation, with IC50 values of 17 and 15 μM for Z-Guggulsterone and E-Guggulsterone, respectively[2].Guggulsterone inhibited LPS-induced expression of TREM-1, TLR4 and TNF-α as well as phosphorylation of IκBα and NF-κB p65 in RAW 264.7 cells at concentrations ranging from 0.5-20 μM for 24 hours of treatment[2].
Guggulsterone/香胶甾酮 动物研究
Animal study
Administered orally at a dose of 100 mg/kg once daily for 8 days, Guggulsterone significantly increased the survival rate of TNBS-induced colitis in wild-type mice[2].
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