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货号 产品名 纯度
A2626759 ERK5-IN-5

98%
A262997 Methylnissolin/黄芪紫檀烷苷

99%+
A994339 Rubrofusarin gentiobioside/芸苔红素龙胆苷

99%+
A466005 δ-Tocotrienol

delta-Tocotrienol, a natural product isolated and purified from palm oil, has superior bioavailability compared to existing Tocotrienol-Rich Fraction in healthy human subjects.

98%
A492049 APS-2-79

APS-2-79 is an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site.

99%+
A154752 Tauroursodeoxycholate sodium/牛磺熊去氧胆酸钠

Tauroursodeoxycholate sodium can suppress ERK via PKCα-mediated MKP-1 induction, thus inhibiting neointimal hyperplasia of smooth muscle cells.

99%+
A109800 Schinifoline/青花椒碱

98%+
A798244 AX-15836

AX 15836 is a potent and selective ERK5 inhibitor with IC50 of 8 nM.

99%+
A1210826 ML192

97%
A1176813 BAY885

BAY-885 is a highly potent and selective ERK5 inhibitor with IC50 value of 35nM.

99%+
A1362224 ASTX029

ASTX-029 is selective inhibitor of the extracellular signal-regulated kinases 1 and 2 (ERK 1/2) with potential antineoplastic activity.

99%+
A214234 Ulixertinib hydrochloride

Ulixertinib HCl, the salt of ulixertinib, is a reversible inhibitor of ERK1/ERK2. It can inhibit cell proliferation.

98%
A315608 DEL-22379

DEL-22379 inhibits ERK dimerization with IC50 of 0.5 μM.

98%
A668057 Temuterkib

LY3214996 can inhibit ERK1 and ERK2 with IC50s of 5 nM.

99%+
A812686 ERK5-IN-1

ERK5-IN-1 exhibits potent inhibition of ERK5 with cellular EC50 values of 0.19 μM and enzymatic IC50 values of 0.087 μM and of LRRK2[G2019S] with enzymatic IC50 values of 0.026μM.

99%+
A891284 Avicularin/扁蓄苷

Avicularin, a natural product isolated and purified from the herbs of Polygonum aviculare., exhibits anti-inflammatory activity through the suppression of ERK signaling pathway in LPS-stimulated RAW 264.7 macrophage cells.

99%+
A162263 Ulixertinib

Ulixertinib is a potent and reversible ERK1/ERK2 inhibitor with IC50 of < 0.3 nM for ERK2.

99%+
A260385 VX-11e

VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK (Extracellular Signal-Regulated Kinase) and is antitumor agent.

99%+
A480964 MK-8353

MK-8353, also known as SCH900353, is a potent and orally active ERK1/2 inhibitor and anticancer drug candidate currently being developed by Schering-Plough. MK-8353 exhibited comparable potency with SCH772984 across various preclinical cancer models.

95%
A183088 Pluripotin

Pluripotin is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. It maintains embryonic stem cell (ESC) self-renewal.

99%+
产品名 ERK ERK1 ERK2 ERK5 其他靶点 纯度
DEL-22379 +

ERK, IC50: 0.5 μM

+

ERK, IC50: 0.5 μM

98%
Pluripotin ++

ERK1, Kd: 98 nM

RasGAP 99%+
FR 180204 +

ERK1, Ki: 0.31 μM

++

ERK2, Ki: 0.14 μM

99%+
Ravoxertinib +++

ERK1, IC50: 1.1 nM

++++

ERK2, IC50: 0.3 nM

99%+
SCH772984 +++

ERK1, IC50: 4 nM

++++

ERK2, IC50: 1 nM

99%+
Temuterkib +++

ERK1, IC50: 5 nM

+++

ERK2, IC50: 5 nM

99%+
VX-11e +++

ERK2, Ki: <2 nM

99%+
Ulixertinib ++++

ERK2, IC50: <0.3 nM

99%+
XMD17-109 ++

ERK5, IC50: 162 nM

99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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