There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
AS-8351 is a histone demethylase inhibitor used to induce the reprogramming of fibroblasts into functional cardiomyocytes. Combination of AS8351 with CHIR99021, A83-01, BIX01294, SC1, Y27632 and OAC2 could efficiently induce cardiac reprogramming.
作用机制
AS8351 affects epigenetic modifications by competing with α-ketoglutarate for chelating iron/Fe(II) required by JmjC-KDMs.[1]
AG126 细胞实验
Cell Line
Concentration
Treated Time
Description
References
GrH2 rat hepatoma cells
1 mM
20 min
AG126 inhibits molybdate-stimulated nuclear export of GR
J Cell Biol. 1997 May 5;137(3):523-38
RAW 264.7 macrophages
20 μM
30 min
Inhibited LTA-induced iNOS expression and NO release
Immunology. 2005 Jul;115(3):366-74
PG tissue culture
100 μM
6 h
AG126 completely suppressed the LPS-induced decrease in AQP5 mRNA.
Am J Pathol. 2010 Aug;177(2):724-34
J774.2 macrophages
10 μM
24 h
To investigate the effect of AG126 on LTA-induced NO synthesis, results showed that AG126 significantly inhibited NO synthesis.
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