Isoquercitrinis can inhibit Wnt/β-catenin and activate the mitogen-activated protein kinase (MAPK) signalling pathway. It is a natural product isolated and purified from the herbs of Prunella vulgaris L. with a good effect of expectorant, cough, asthma and anti-tumoral activity.

IQ-1 enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation, Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells and prevents PP2A/Nkd interaction.

KYA1797K是一种有效的Wnt/β-连环蛋白通路抑制剂，IC50为0.75 µM。

Windorphen 是一种 Wnt/β-catenin信号抑制剂，选择性靶向 β-catenin-1 的 C 末端转录激活域，而不靶向 β-catenin-2。Windorphen 选择性破坏哺乳动物 β-catenin 与 p300 的关联，而不影响 CBP。

FH535是一种Wnt/β-catenin和PPAR的抑制剂，具有抗肿瘤活性。

JW74 is an efficient and specific inhibitor of the canonical Wnt signaling.

IWR-1是一种抑制Wnt/β-连环蛋白信号通路的tankyrase抑制剂。

Methyl vanillate has ability to increase bone mass and activate wnt/β-catenin pathway. It can act as a potential lead anabolic agent for anti-osteoporosis drugs.

BML-284 is a Wnt signaling activator with EC50 value of 0.7 μM for inducing β-catenin and TCF-dependent transcriptional activity.

CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with IC50 value of 5 nM.

iCRT3 can inhibit both Wnt and β-catenin-responsive transcription.

for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities[1][2].

IWP-2 is an inhibitor of porcn-mediated Wnt palmitoylation and secretion with IC50 of 27 nM.