There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
FH535 is a compound that suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling.
FH535 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Caco2 cells
20 µM
2 hours
To verify the protective effect of BBR on TNF-α induced TJ damage in Caco2 cells
Int J Biol Sci. 2022 Jan 16;18(4):1381-1397.
KYSE-150R cells
20 µM
24 hours
FH535 reduced the expression of nuclear β-catenin, reversed EMT phenotypes, and increased the radiosensitivity of KYSE-150R cells.
J Transl Med. 2015 Mar 31;13:104.
ARPE-19 cells
0.5 µM
48 hours
To assess the impact of FH535 on the activation of EMT; FH535 treatment significantly attenuated the increase of EMT-related markers in TGFβ1-treated ARPE-19 cells.
J Neuroinflammation. 2024 Mar 26;21(1):75.
Transformed human hepatocytes (THH)
5 µM
48 hours
The combination of AZD5363 and FH535 treatment displays a much greater (~80%) cell death.
Cell Death Dis. 2020 Jul 17;11(7):540.
HTR-8/SVneo cells
30 mM
72 hours
To investigate the effect of FH535 on glucose uptake and apoptosis in HTR-8/SVneo cells under high glucose conditions. The results showed that FH535 treatment reversed the glucose uptake dysfunction and apoptosis induced by high glucose.
Biol Res. 2023 Aug 22;56(1):48.
FH535 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
Laser-induced CNV model
Intravitreal injection
0.5 μmol/L
Single treatment
To evaluate the effect of FH535 on subretinal fibrosis; the area of transformed RPE was reduced by 52.57%.
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