MEDI9197 is an imidazoquinoline analogue toll-like receptor (TLR) agonist that can be used for cancer immunotherapy based on its efficacy toward a variety of tumors.
Telratolimod 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Bone marrow-derived macrophages
100 nM
Promoted M1 polarization of macrophages and significantly decreased the subset of M2 macrophages.
Adv Sci (Weinh). 2023 Feb;10(5):e2206001.
Human newborn and adult leukocytes
0.01, 0.1, 1, 10, 100 μM
6 h
3M-052 alone or in combination with PCV13 significantly induced TNF and IFN-γ production in both newborn and adult blood, with synergistic effects when combined with PCV13.
JCI Insight. 2017 Mar 23;2(6):e91020.
Telratolimod 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6 mice
B16F10 melanoma model
Intratumoral injection
0.2 mg/kg
Injected on day 0 and day 3
Suppressed local tumor growth, increased M1 macrophages, and improved CD8+ T cell-mediated immune responses.
Adv Sci (Weinh). 2023 Feb;10(5):e2206001.
Rhesus macaques
SARS-CoV-2 infection model
Intramuscular injection
10 μg
3 immunizations, 4 and 5 weeks apart
To evaluate the immunogenicity and protective efficacy of the RBD + 3M-052-alum vaccine in rhesus macaques, showing that the vaccine induced stronger antibody and T cell responses and significantly reduced viral load after SARS-CoV-2 challenge.
Sci Immunol. 2021 Jul 15;6(61):eabh3634
Rhesus macaques
Rhesus macaque model
Subcutaneous injection
750μg, 75μg
Immunizations at weeks 0, 6, 12, and 18, lasting up to 70 weeks
The 3M-052 adjuvant significantly enhanced the magnitude and durability of HIV-1 Env-specific antibody responses, particularly inducing durable Env-specific LLPCs in the bone marrow.
Sci Immunol. 2020 Jun 19;5(48):eabb1025
Rhesus macaques
Neonatal rhesus macaques
Intramuscular injection
0.1 mg/kg
Single dose at birth
3M-052 significantly accelerated and enhanced neonatal B and T cell immune responses, rapidly exceeding protective antibody levels after a single dose.
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