EC5026 is a first-in-class, small molecule that potently inhibits soluble Epoxide Hydrolase (sEH), a key regulatory enzyme involved in the metabolism of membrane fatty acids.

sEH inhibitor-7是一种可溶性环氧化物水解酶 (sEH) 抑制剂，显示出对小鼠和人类 sEH 的高效抑制作用，适用于血压和炎症调节相关的研究。

BI-1935是一种有效的可溶性环氧化物水解酶 (sEH) 抑制剂，广泛用于心血管疾病的研究，特别是与血压调节和炎症相关的研究。

GSK2256294A is a potent, reversible, tight binding inhibitor of isolated recombinant human sEH (soluble epoxide hydrolase) (IC50 = 27 pM; t1/2 = 121 min) and displays potent inhibition against the rat (IC50 = 61 pM) and murine (IC50 = 189 pM) orthologs of sEH.

TTPU is an inhibitor of epoxide hydrolase (sEH) with IC50 of 3.7 nM with anti-inflammatory and anti-atherosclerotic activities.

PTUPB is a novel dual COX2 and sHE (soluble epoxide hydrolase) inhibitor. Treatment with PTUPB reduced body weight, liver weight, liver triglyceride and cholesterol content, and the expression of lipolytic/lipogenic and lipid uptake related genes (Acc, Cd36, and Cidec) in HFD mice. This made it be a promising potential therapy for liver steatosis associated with obesity.

AUDA is a potent soluble epoxide hydrolase (sEH) inhibitor with IC50s of 18 and 69 nM for the mouse and human sEH, respectively and with anti-inflammatory activity.

Diflapolin is a dual inhibitor of both FLAP and sEH. It inhibited 5-LOX product formation in intact human monocytes and neutrophils with IC50 = 30 and 170 nM, respectively, and suppressed the activity of isolated sEH (IC50 = 20 nM).

CUDA is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC50s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively[1]. CUDA selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity. CUDA may be valuable for the research of cardiovascular disease[2].

VU534是一种NAPE-PLD激动剂，其EC50为0.30 μM。它是FAAH和sEH的双重抑制剂（IC50值为1.2 μM）。VU534通过NAPE-PLD依赖性途径增强巨噬细胞的吞噬作用，并在心血管代谢性疾病的研究中具有潜力。

N-(3-Methoxybenzyl)stearamide是从 Maca (Lepidium meyenii) 中分离得到的天然产物，能够抑制人类和小鼠的可溶性环氧化物水解酶（hsEH 和 msEH），IC50 分别为 0.001 和 <0.001 μg/nM。