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货号 产品名 纯度
A221051 现货 (E/Z)-Locostatin

(E/Z)-Locostatin是一种RKIP抑制剂,能够破坏RKIPRaf-1激酶的相互作用,抑制细胞增殖和迁移,在研究肝脏衰竭和细胞迁移中展现重要应用。

95%
A986611 现货 L-779450

L-779450 is a potent, ATP-competitive Raf kinase inhibitor (IC50 =10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively.

98%+
A292940 现货 B-Raf IN 1

B-Raf IN 1 is a highlt potent and selective B-Raf inhibitor with IC50 of 24 nM, equipotent against c-Raf (IC50= 25 nM).

99%+
A880021 现货 Raf inhibitor 2

Raf inhibitor 2是一种有效的raf激酶抑制剂,能够调节细胞增殖和凋亡过程,适用于癌症研究。

98%
A202142 现货 LJH685

LJH685 is a potent pan-RSK inhibitor with IC50 of 6 nM, 5 nM and 4 nM for RSK1, RSK2, and RSK3, respectively.

99%+
A802126 现货 AZ304

AZ304 is an inhibitor of BRAF and can target many kinases. The IC50s for wild type BRAF, V600E mutant BRAF and wild type CRAF are 79 nM, 38 nM and 68 nM, respectively. It can also inhibit p38 (IC50 = 6 nM) and CSF1R (IC50 = 35 nM).

99%+
A1530789 现货 GNE-9815

GNE-9815是一种有效的、高度选择性的泛RAF抑制剂,具有出色的口服生物利用度。它对CRAF和BRAF的Ki值分别为0.062 nM和0.19 nM。与MEK抑制剂Cobimetinib结合使用,GNE-9815可以有效调节MAPK途径,适用于KRAS突变癌症的研究。

98%
A1371593 现货 KG5

KG5是一种口服活性双重 PDGFRβB-Raf 变构抑制剂,具有抗癌和抗血管生成作用,还能抑制 Flt3、KIT 和 c-Raf,适用于多种癌症的治疗研究,特别是在血管生成相关的肿瘤中具有广泛应用前景。

97%
A720977 现货 SB-590885

SB-590885 is a potent B-Raf inhibitor with Ki of 0.16 nM, 11-fold greater selectivity for B-Raf over c-Raf, no inhibition to other human kinases.

99%+
A103377 现货 Doramapimod/达马莫德

Doramapimod is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2, ZAP-70, EGFR, HER2, PKA, PKC, PKCα/β/γ.

99%+
A312190 现货 Encorafenib

Encorafenib is a potent and selective B-RafV600E inhibitor, with no significant activity observed against a panel of 100 kinases (IC50>900nM).

99%+
A289395 现货 GDC-0879

GDC-0879 is a potent, and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well, displaying no inhibition known to other protein kinases.

99%+
A417155 现货 LY3009120

LY3009120(DP-4978)是一种广谱RAF抑制剂,抑制BRAFV600E、BRAFWT和CRAFWT的IC50值分别为5.8 nM、9.1 nM和15 nM。

99%+
A107516 现货 Tovorafenib

Tovorafenib (TAK-580, MLN 2480) 是一种可口服的,具有选择性的广谱的 Raf 抑制剂。Tovorafenib (TAK-580, MLN 2480) 通过抵消 TAK-733 触发的 MEK 反馈激活,导致 MAPK 通路的协调抑制。

99%+
A1669343 现货 Norartocarpetin

Norartocarpetin 是一种酪氨酸抑制剂,具有较强的抑制活性,IC50 为 0.47 μM。它作为一种抗褐变剂可用于食品体系的研究,对肺癌细胞 (NCI-H460) 也具有显著的抗癌活性,IC50 为 22 μM。

95%
A552174 现货 AZ 628

AZ 628 is a pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.

99%
A840010 现货 PLX8394

PLX8394是一种高效、选择性的BRaf抑制剂,对BRAFV600E的IC50约为5 nM。

99%+
A1158776 现货 Belvarafenib

Belvarafenib is a pan-RAF inhibitor, with IC50 values of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFV600E and C-RAF, respectively.

99%+
A175274 现货 ZM 336372

ZM336372 is an inhibitor of c-Raf with IC50 of 70 nM.

99%+
A684624 现货 RAF709

RAF709 is an inhibitor of c-Raf and b-Raf with IC50 of 0.5 nM and 1.8 nM, respectively.

99%+
产品名 A-raf B-Raf C-Raf/Raf-1 Raf 其他靶点 纯度
Encorafenib 99%+
GDC-0879 ++++

B-Raf, IC50: 0.13 nM

99%+
SB-590885 ++++

B-Raf, Ki: 0.16 nM

99%+
RAF265 99%+
Dabrafenib ++++

B-Raf (V600E), IC50: 0.7 nM

B-Raf, IC50: 5.2 nM

+++

C-Raf, IC50: 6.3 nM

98%
Lifirafenib ++++

WT A-RAF, IC50: 1 nM

++

BRAF WT, IC50: 32 nM

BRAF(V600E), IC50: 23 nM

+++

C-RAF (Y340/341D), IC50: 7 nM

EGFR 96%
ZM 336372 +

C-Raf, IC50: 70 nM

99%+
NVP-BHG 712 +

C-Raf, IC50: 0.395 μM

99%+
CCT196969 +

BRAF, IC50: 0.1 μM

++

CRAF, IC50: 0.01 μM

Src 98%
Vemurafenib ++

B-Raf (V600E), IC50: 31 nM

B-Raf, IC50: 100 nM

+

C-Raf, IC50: 48 nM

98+%
PLX4720 ++

B-Raf (V600E), IC50: 13 nM

B-Raf, IC50: 160 nM

+++

C-Raf-1 (Y340D/Y341D), IC50: 6.7 nM

BRK 99+%
GW 5074 +++

C-Raf, IC50: 9 nM

99%+
Avutometinib +++

BRAF V600E, IC50: 8.2 nM

BRAF, IC50: 19 nM

+

CRAF, IC50: 56 nM

98%
LY3009120 ++++

BRAF WT, IC50: 15 nM

BRAF(V600E), IC50: 5.8 nM

++++

C-Raf, IC50: 4.3 nM

99%+
Agerafenib ++

B-Raf, Kd: 36 nM

B-Raf (V600E), Kd: 14 nM

+

C-Raf, Kd: 39 nM

RET 99%+
TAK-632 +++

B-Raf, IC50: 8.3 nM

++++

C-Raf, IC50: 1.4 nM

99%+
AZ 628 +

B-Raf (V600E), IC50: 34 nM

B-Raf, IC50: 105 nM

++

C-Raf-1, IC50: 29 nM

99%
PLX7904 98+%
Sorafenib ++

B-Raf, IC50: 22 nM

B-Raf (V599E), IC50: 38 nM

++++

Raf-1, IC50: 6 nM

++++

Raf-1, IC50: 6 nM

99%
Tovorafenib 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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