Urolithin A/尿石素A
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货号：A278438
同义名：
2',7-Dihydroxy-3,4-benzocoumarin; 3,8-Dihydroxy Urolithin
Urolithin A 是一种来自鞣花酸的代谢产物，具有抗增殖和抗氧化特性，能够穿越血脑屏障，可能对阿尔茨海默病具有神经保护作用。它能刺激线粒体自噬并改善衰老动物和肌肉萎缩症模型中的肌肉功能。
Urolithin A/尿石素A 化学结构
Urolithin A/尿石素A 3D分子结构
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Urolithin A/尿石素A 纯度/质量文件 产品仅供科研
货号：A278438
标准纯度：
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产品说明书
全球学术期刊中引用的产品
• Science , 2025, 387(6729): eadp5637. Ambeed. • Nat. Electron. , 2025, 8, 66-74. Ambeed. • Adv. Mater. , 2025, 2416621. Ambeed. • Adv. Mater. , 2025, 2410493. Ambeed. • Adv. Mater. , 2025, 2420319. Ambeed. A106129
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Urolithin A/尿石素A 质控信息
Urolithin A/尿石素A 生物活性
描述
Urolithin A, the intestinal microbial metabolite of ellagic acid, has the characteristics of anti-inflammatory, anti-proliferation and anti-oxidation. Urolithin A imparted cognitive protection by protecting neurons from death and triggering neurogenesis via anti-inflammatory signaling in APP/PS1 mice[3] [3] [4]
Urolithin A/尿石素A 参考文献
[1] Ryu D, Mouchiroud L, et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat Med. 2016 Aug;22(8):879-88.
[2] Ishimoto H, Shibata M, et al. In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5901-4.
[3] Gong Z, Huang J, Xu B, Ou Z, Zhang L, Lin X, Ye X, Kong X, Long D, Sun X, He X, Xu L, Li Q, Xuan A. Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice. J Neuroinflammation. 2019 Mar 14;16(1):62. doi: 10.1186/s12974-019-1450-3. PMID: 30871577; PMCID: PMC6417212.
[4] Wang Y, Qiu Z, Zhou B, Liu C, Ruan J, Yan Q, Liao J, Zhu F. In vitro antiproliferative and antioxidant effects of urolithin A, the colonic metabolite of ellagic acid, on hepatocellular carcinomas HepG2 cells. Toxicol In Vitro. 2015 Aug;29(5):1107-15. doi: 10.1016/j.tiv.2015.04.008. Epub 2015 Apr 21. PMID: 25910917.
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Urolithin A/尿石素A 实验方案
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存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
4.38mL
0.88mL
0.44mL
21.91mL
4.38mL
2.19mL
43.82mL
8.76mL
4.38mL
Urolithin A/尿石素A 技术信息
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