Urolithin A

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Chemical Structure| 1143-70-0 同义名 : 2',7-Dihydroxy-3,4-benzocoumarin; 3,8-Dihydroxy Urolithin
CAS号 : 1143-70-0
货号 : A278438
分子式 : C13H8O4
纯度 : 99%
分子量 : 228.2
MDL号 : MFCD20275235
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(131.46 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Urolithin A, the intestinal microbial metabolite of ellagic acid, has the characteristics of anti-inflammatory, anti-proliferation and anti-oxidation. Urolithin A imparted cognitive protection by protecting neurons from death and triggering neurogenesis via anti-inflammatory signaling in APP/PS1 mice[3]. Urolithin A shows antiproliferative effects and inhibits T24 and Caco-2 cell growth with IC50s of 43.9 and 49 μM, respectively[3]. Moreover, inhibiting effects on cell proliferation in a dose-dependent manner (IC50 = 137 ± 8.2 μM) after 24 h treatment of Urolithin A. Administration of 100–250 μM of Urolithin A results in the down-regulation of β-catenin/TCF dependent transcriptional activation in HepG2 cells[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.38mL

0.88mL

0.44mL

21.91mL

4.38mL

2.19mL

43.82mL

8.76mL

4.38mL
参考文献

[1]Ryu D, Mouchiroud L, et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat Med. 2016 Aug;22(8):879-88.

[2]Ishimoto H, Shibata M, et al. In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5901-4.

[3]Gong Z, Huang J, Xu B, Ou Z, Zhang L, Lin X, Ye X, Kong X, Long D, Sun X, He X, Xu L, Li Q, Xuan A. Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice. J Neuroinflammation. 2019 Mar 14;16(1):62. doi: 10.1186/s12974-019-1450-3. PMID: 30871577; PMCID: PMC6417212.

[4]Wang Y, Qiu Z, Zhou B, Liu C, Ruan J, Yan Q, Liao J, Zhu F. In vitro antiproliferative and antioxidant effects of urolithin A, the colonic metabolite of ellagic acid, on hepatocellular carcinomas HepG2 cells. Toxicol In Vitro. 2015 Aug;29(5):1107-15. doi: 10.1016/j.tiv.2015.04.008. Epub 2015 Apr 21. PMID: 25910917.