There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
E7449 is an orally bioavailable, potent, small molecule inhibitor of PARP1 and PARP2 and enhances the efficacy of radiotherapy and chemotherapy and has potent single agent anticancer activity in BRCA-deficient tumors.
Stenoparib 细胞实验
Cell Line
Concentration
Treated Time
Description
References
DLD-1 cells
10 μmol/L
24 h
To evaluate the effect of E7449 on Wnt signaling, results showed increased axin2 protein levels.
Oncotarget. 2015 Dec 1;6(38):41307-23.
SW480 cells
10 μmol/L
24 h
To evaluate the effect of E7449 on Wnt signaling, results showed increased axin2 protein levels and decreased β-catenin levels.
Oncotarget. 2015 Dec 1;6(38):41307-23.
DT40 cells
0.1-10 μmol/L
30 min
To evaluate the role of E7449 in DNA damage repair, results showed increased PARP1 binding to chromatin.
Oncotarget. 2015 Dec 1;6(38):41307-23.
LLC-MK2 rhesus macaque kidney cells
30 μM
120 hours
Evaluate the inhibitory effect of Stenoparib on HCoV-NL63, showing a 69.3% reduction in plaquing efficiency and 95.8% reduction in viral copy number
mBio. 2021 Jan 19;12(1):e03495-20.
Calu-3 human lung adenocarcinoma cells
60 μM
120 hours
Evaluate the inhibitory effect of Stenoparib on SARS-CoV-2, showing nearly complete inhibition of plaque formation (94.0%)
mBio. 2021 Jan 19;12(1):e03495-20.
Vero E6 monkey kidney cells
30 μM
48 hours
Evaluate the inhibitory effect of Stenoparib on SARS-CoV-2, showing a significant 63.2% reduction in viral load
mBio. 2021 Jan 19;12(1):e03495-20.
A549 cells
10 mol/L
48 hours
E7449 significantly downregulated TNKS expression, inhibited proliferation, migration, and invasion of A549 cells, and induced early apoptosis.
J Cell Mol Med. 2024 Jun;28(12):e18467.
A549L6 cells
5.753 µM (IC50)
96 hours
Evaluate the inhibitory effect of E7449 on proliferation and migration of A549L6 cells
Cancers (Basel). 2025 Feb 6;17(3):559.
Stenoparib 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
B16-F10 isograft model
Orally
10, 30, 100 mg/kg
Once daily for 7 days
To evaluate the antitumor effect of E7449 in combination with TMZ, results showed significantly enhanced tumor growth inhibition.
Oncotarget. 2015 Dec 1;6(38):41307-23.
BALB/c nude mice
Subcutaneous xenograft model with A549 cells
Gavage
100 mg/kg
Once daily for 14 days
E7449 significantly inhibited the growth of subcutaneous lung adenocarcinoma tumors and induced apoptosis by attenuating the Wnt signaling pathway.
J Cell Mol Med. 2024 Jun;28(12):e18467.
BALB/c nude mice
LUAD bone metastasis model
Oral
40 mg/kg
Once daily for 21 days
Evaluate the inhibitory effect of E7449 on bone metastasis
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