Stenoparib

产品说明书

Print
Chemical Structure| 1140964-99-3 同义名 : E7449; 2X-121; MGI25036
CAS号 : 1140964-99-3
货号 : A439847
分子式 : C18H15N5O
纯度 : 98%
分子量 : 317.34
MDL号 : MFCD28167842
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 5 mg/mL(15.76 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • PARP1

    PARP1, IC50:1 nM

  • PARP2

    PARP2, IC50:1.2 nM
描述 E7449 is an orally bioavailable, potent, small molecule inhibitor of PARP1 and PARP2 and enhances the efficacy of radiotherapy and chemotherapy and has potent single agent anticancer activity in BRCA-deficient tumors.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.15mL

0.63mL

0.32mL

15.76mL

3.15mL

1.58mL

31.51mL

6.30mL

3.15mL
参考文献

[1]McGonigle S, Chen Z, et al. E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling. Oncotarget. 2015 Dec 1;6(38):41307-23.