JAK2 (Janus kinase 2) is a non-receptor tyrosine kinase. The mutation of it, JAK2V617F, which activates JAK2 signaling, is discovered in patients with myeloproliferative neoplasms[2]. Ruxolitinib, also called as INCB018424, is the first potent, selective, oral JAK1/JAK2 inhibitor to enter the clinic with IC50 values of 3.3 nM and 2.8 nM (measured by homogeneous time-resolved fluorescence assay), respectively. A dose-dependent reduction in the phosphorylated forms of JAK2, STAT5 and ERK1/2 can be seen in Ba/F3-EpoRJAK2V617F cells treated with ruxolitinib, which has constitutive phosphorylation of JAK2 as well as downstream targets. Ruxolitinib inhibits hematopoietic progenitor cell proliferation in primary MPN patient samples. Orally treatment of ruxolitinib can improve viability and splenomegaly in a JAK2V617F-driven mouse model of malignant disease[1]. Ruxolitinib is mainly used in treatment of myelofibrosis and autoimmune diseases due its anti-inflammatory and immunomodulating activity, such as affecting DC differentiation and function of leading to impaired T-cell activation significantly[3].
作用机制
Ruxolitinib binds in the ATP binding pocket of the kinase domain in its active configuration.[4]
Ruxolitinib/芦可替尼 细胞实验
Cell Line
Concentration
Treated Time
Description
References
BaF3-MPLW515L
46 nM
Evaluate the efficacy of ruxolitinib in the presence and absence of IL3
Leukemia. 2023 Aug;37(8):1686-1697.
Karpas-1106P cells
25 nM
48 h
significant inhibition of phosphorylation of STAT3 and STAT6
Oncotarget. 2018 Jan 18;9(11):9776-9788.
BaF3-Jak2V617F
79 nM
Evaluate the efficacy of ruxolitinib in the presence and absence of IL3
Leukemia. 2023 Aug;37(8):1686-1697.
L-428 cells
25 nM
48 h
significantly downregulated phosphorylation of STAT3, STAT5 and STAT6
Oncotarget. 2018 Jan 18;9(11):9776-9788.
Human aortic smooth muscle cells (hVSMCs)
1 µM
1 h
Inhibited CKD serum-induced IFN-I response, premature senescence, and phenotypic switching
Adv Sci (Weinh). 2021 Jan 6;8(5):2002738.
BaF3-CALRmut
57 nM
Evaluate the efficacy of ruxolitinib in the presence and absence of IL3
Leukemia. 2023 Aug;37(8):1686-1697.
L-428 cells
1, 10, 100 uM
48 h
significant decrease in cell proliferation
Oncotarget. 2018 Jan 18;9(11):9776-9788.
Karpas-1106P cells
1, 10, 100 uM
48 h
significant inhibition of cell proliferation
Oncotarget. 2018 Jan 18;9(11):9776-9788.
HDLM-2 cells
1, 10, 100 uM
48 h
significant inhibition of cell proliferation
Oncotarget. 2018 Jan 18;9(11):9776-9788.
HS27a bone marrow mesenchymal cells
100 nM
1 hour
Evaluate the effect of Ruxolitinib on collagen expression, showing that the combination of Ruxolitinib with Nilotinib and Prednisone inhibited collagen expression
Haematologica. 2019 May;104(5):937-946.
SET2 JAK2 V617F cells
25 nM
Evaluate the inhibitory effect of Ruxolitinib on JAK2 V617F mutant cells, showing an EC50 of 25 nM for SET2 JAK2 V617F cells
Haematologica. 2019 May;104(5):937-946.
BA/F3 JAK2 V617F cells
35 nM
Evaluate the inhibitory effect of Ruxolitinib on JAK2 V617F mutant cells, showing an EC50 of 35 nM for BA/F3 JAK2 V617F cells
Haematologica. 2019 May;104(5):937-946.
LX-2 cells
0.1–100 μM
24 h
Ruxolitinib inhibited the proliferation, migration, and promoted apoptosis of LX-2 cells.
J Transl Med. 2022 Apr 5;20(1):157.
HDLM-2 cells
10-100 nM
24 h
significantly inhibited downstream active phosphorylated STAT3 and STAT5
Oncotarget. 2018 Jan 18;9(11):9776-9788.
NRK-52E cells
5μM
24 h
Ruxolitinib compensated for TGF-β1-induced loss of E-cadherin and blocked TGF-β1-induced upregulation of α-SMA, Snail, and Twist.
Int J Biol Sci. 2020 Jan 1;16(2):194-203.
NRK-49F cells
5μM
24 h
Ruxolitinib suppressed TGF-β1-induced NRK-49F cell proliferation and down-regulated TGF-β1-induced α-SMA, Collagen I, and Fibronectin expression.
Significantly prolonged survival and decreased tumor burden
Oncotarget. 2018 Jan 18;9(11):9776-9788.
C57BL/6 mice
Unilateral ureteral obstruction (UUO) model
Oral
30 mg/kg
Twice daily for 14 days
Ruxolitinib alleviated UUO-induced renal damage, ECM deposition, renal fibrosis, inflammation, and oxidative stress, and suppressed the activation of Stat3 and Akt/mTOR/Yap pathways.
Terminated(The study was termi... 展开 >>nated as other related studies of ruxolitinib did not provide sufficient efficacy to warrant continuation.) 收起 <<
Terminated(The study was termi... 展开 >>nated as other related studies of ruxolitinib did not provide sufficient efficacy to warrant continuation.) 收起 <<
Terminated(The study was termi... 展开 >>nated as other related studies of ruxolitinib did not provide sufficient efficacy to warrant continuation.) 收起 <<
Suspended(Study is currently o... 展开 >>n hold pending amendment update.) 收起 <<
December 2019
United States, California
... 展开 >>
Children's Hospital of Los Angeles
Los Angeles, California, United States, 90027
Rady Children's Hospital - San Diego
San Diego, California, United States, 92123
United States, Colorado
National Jewish Health
Denver, Colorado, United States, 80206
United States, Illinois
Northwestern University Department of Dermatology
Chicago, Illinois, United States, 60611
United States, Michigan
David Fivenson, MD, Dermatology, PLC
Ann Arbor, Michigan, United States, 48103
United States, North Carolina
Wake Research Associates
Raleigh, North Carolina, United States, 27612
United States, Pennsylvania
Penn State Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
United States, Texas
Texas Dermatology and Laser Specialist Clinical Research
San Antonio, Texas, United States, 78218 收起 <<
United States, Florida
... 展开 >>
Florida Cancer Specialists-Broadway, Fort Myers
Fort Myers, Florida, United States, 33908
Florida Cancer Specialist, North Region
Saint Petersburg, Florida, United States, 33705
Florida Cancer Specialists
West Palm Beach, Florida, United States, 33401
United States, Ohio
Oncology Hematology Care Inc
Cincinnati, Ohio, United States, 45242
United States, Tennessee
Sarah Cannon Research Institute
Nashville, Tennessee, United States, 37203
United States, Texas
Uni of Texas - Md Anderson Cancer Center; Dept of Leukemia
Houston, Texas, United States, 77030
Canada, Alberta
Tom Baker Cancer Centre-Calgary; Clinical Research Unit
Calgary, Alberta, Canada, T2N 4N2
Canada, Nova Scotia
Queen Elizabeth II Health Sciences Centre; Oncology
Halifax, Nova Scotia, Canada, B3H 2Y9
Canada, Quebec
Centre Hospitalier De L'Universite De Montreal, Hopital Notre-Dame
Montreal, Quebec, Canada, H2L 4M1
Germany
Uniklinik RWTH Aachen; Med. Klinik IV; Klinik für Hämatologie, Onkologie, Hämostaseologie und Stammz
Aachen, Germany, 52074
Campus Virchow-Klinikum Charité Centrum 14; Medizinische Klinik m.S. Hämatologie u. Onkologie
Berlin, Germany, 13353
Italy
A.O.U. Citta' Della Salute E Della Scienza-P.O. Molinette;S.C. Ematologia
Torino, Piemonte, Italy, 10126
Az. Osp. Di Careggi; Divisione Di Ematologia
Firenze, Toscana, Italy, 50135 收起 <<
Idiopathic Myelofibrosis
... 展开 >> Post Essential Thrombocythemia Myelofibrosis
Post Polycythemia-Vera Myelofibrosis 收起 <<
Phase 1
Active, not recruiting
December 31, 2018
France
... 展开 >> Novartis Investigative Site
Paris, France, 75010
Novartis Investigative Site
Villejuif Cedex, France, 94805
Germany
Novartis Investigative Site
Magdeburg, Germany, 39120
Novartis Investigative Site
Mainz, Germany, 55131
Ireland
Novartis Investigative Site
Dublin, Ireland, DUBLIN 8
Novartis Investigative Site
Galway, Ireland
Italy
Novartis Investigative Site
Firenze, FI, Italy, 50134
Novartis Investigative Site
Reggio Calabria, RC, Italy, 89124
Novartis Investigative Site
Varese, VA, Italy, 21100
United Kingdom
Novartis Investigative Site
London, United Kingdom, SE1 9RT 收起 <<
T Cell Leukemia, Adult
... 展开 >> Leukemia, Adult T-Cell
T Cell Leukemia, HTLV I Associated 收起 <<
Phase 2
Recruiting
November 1, 2021
United States, Maryland
... 展开 >>
National Institutes of Health Clinical Center, 9000 Rockville Pike
Recruiting
Bethesda, Maryland, United States, 20892
Contact: For more information at the NIH Clinical Center contact National Cancer Institute Referral Office 888-624-1937 收起 <<
Korea, Republic of
... 展开 >>
Seoul National University Bundang Hospital
Recruiting
Seongnam, Korea, Republic of, 13620
Contact: Ryul Kim, Dr +82 10 9412 6108 chrono0707@icloud.com
Seoul National University Hospital
Recruiting
Seoul, Korea, Republic of, 03080
Contact: Ryul Kim, MD +82 10 9412 6108 chrono0707@icloud.com
Principal Investigator: Youngil Koh, MD
Sub-Investigator: Sung soo Yoon, MD, PhD
Sub-Investigator: In ho Kim, MD
Sub-Investigator: Ryul Kim, MD 收起 <<
United States, California
... 展开 >>
Stanford Cancer Institute Palo Alto
Recruiting
Palo Alto, California, United States, 94304
Contact: Jason Gotlib 650-736-1253 gotlib@stanford.org
Principal Investigator: Jason Gotlib
United States, Georgia
Emory University Hospital/Winship Cancer Institute
Recruiting
Atlanta, Georgia, United States, 30322
Contact: Elliott F. Winton 404-778-4755 ewinton@emory.edu
Principal Investigator: Elliott F. Winton
United States, Missouri
Washington University School of Medicine
Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Stephen Oh 314-362-8846 stoh@dom.wustl.edu
Principal Investigator: Stephen Oh
United States, Oregon
OHSU Knight Cancer Institute
Recruiting
Portland, Oregon, United States, 97239
Contact: Kim-Hien Dao 503-494-7894 daok@ohsu.edu
Principal Investigator: Kim-Hien Dao
United States, Texas
UT Southwestern/Simmons Cancer Center-Dallas
Recruiting
Dallas, Texas, United States, 75390
Contact: Robert H. Collins 214-648-4155 robert.collins@utsouthwestern.edu
Principal Investigator: Robert H. Collins
M D Anderson Cancer Center
Recruiting
Houston, Texas, United States, 77030
Contact: Jorge E. Cortes 713-794-5783 jcortes@mdanderson.org
Principal Investigator: Jorge E. Cortes
United States, Utah
Huntsman Cancer Institute/University of Utah
Recruiting
Salt Lake City, Utah, United States, 84112
Contact: Michael W. Deininger 801-213-5684 michael.deininger@hci.utah.edu
Principal Investigator: Michael W. Deininger 收起 <<
Terminated(The safety committe... 展开 >>e found no safety issues but recommended halting the study based on a lack of efficacy in a similar trial. The sponsor terminated the trial.) 收起 <<
Terminated(The study was termi... 展开 >>nated as other related studies of ruxolitinib did not provide sufficient efficacy to warrant continuation.) 收起 <<
United States, Florida
... 展开 >>
University of Miami
Recruiting
Miami, Florida, United States
Contact: Jonathan Schatz, MD 305-689-5511
United States, Massachusetts
Dana Farber Cancer Institute
Recruiting
Boston, Massachusetts, United States, 02115
Contact: Eric Jacobsen, MD 617-582-9086
United States, New Jersey
Memorial Sloan Kettering Basking Ridge
Recruiting
Basking Ridge, New Jersey, United States, 07920
Contact: Alison Moskowitz, MD 212-639-4839
United States, New York
Memorial Sloan Kettering Commack
Recruiting
Commack, New York, United States, 11725
Contact: Alison Moskowitz, MD 212-639-4839
Memorial Sloan Kettering Westchester
Recruiting
Harrison, New York, United States, 10604
Contact: Alison Moskowitz, MD 212-639-4839
Memorial Sloan Kettering Cancer Center
Recruiting
New York, New York, United States, 10065
Contact: Alison Moskowitz, MD 212-639-4839
Contact: Steven Horwitz, MD 212-639-3045
Principal Investigator: Allison Moskowitz, MD
Weill Cornell Medical Center
Recruiting
New York, New York, United States
Contact: Jia Ruan, MD 646-962-2064
Principal Investigator: Jia Ruan, MD 收起 <<
Germany
... 展开 >> Universitätsklinkum Aachen
Recruiting
Aachen, Germany, 52074
Contact: Edgar Jost, PD Dr. ejost@ukaachen.de
Principal Investigator: Edgar Jost, PD Dr.
Sub-Investigator: Martina Crysandt, Dr.
HELIOS Klinikum Berlin-Buch
Recruiting
Berlin, Germany, 13125
Contact: Herrad Baurmann, Dr. herrad.baurmann@helios-kliniken.de
Principal Investigator: Herrad Baurmann, Dr.
Sub-Investigator: Stephan Fuhrmann, Dr.
Universitätsklinikum Bonn
Recruiting
Bonn, Germany, 53105
Contact: Dominik Wolf, Prof. Dr. dominik.wolf@ukb.uni-bonn.de
Principal Investigator: Dominik Wolf, Prof. Dr.
Sub-Investigator: Karin Mayer, Dr.
Universitätsklinikum Düsseldorf
Recruiting
Düsseldorf, Germany, 40225
Contact: Guido Kobbe, Prof. Dr. Kobbe@med.uni-duesseldorf.de
Principal Investigator: Guido Kobbe, Prof. Dr.
Sub-Investigator: Thomas Schröder, PD Dr.
Universitätsklinikum Essen
Recruiting
Essen, Germany, 45147
Contact: Joachim Göthert, Dr. Joachim.Goethert@uk-essen.de
Principal Investigator: Joachim Göthert, Dr.
Sub-Investigator: Jürgen Novotny, PD Dr.
Klinikum Frankfurt (Oder) GmbH
Not yet recruiting
Frankfurt (Oder), Germany, 15236
Contact: Michael Kiehl, Prof. Dr.
Contact: Olaf Hopfer, Dr.
Principal Investigator: Olaf Hopfer, Dr.
Sub-Investigator: Georgios Fellas
Universitätsklinkum Halle
Recruiting
Halle (Saale), Germany, 06120
Contact: Haifa Kathrin Al-Ali, PD Dr. haifa.al-ali@uk-halle.de
Principal Investigator: Haifa Kathrin Al-Ali, PD Dr.
Sub-Investigator: Nadja Jäkel, Dr.
University Medical Center Hamburg-Eppendorf
Recruiting
Hamburg, Germany, 20246
Contact: Nicolaus Kroeger, Prof. Dr. +49-40-7410-55864 n.kroeger@uke.de
Contact: Marion Heinzelmann +49-40-7410-54188 mheinzel@uke.de
Principal Investigator: Nicolaus Kroeger, Prof. Dr.
Sub-Investigator: Christine Wolschke, Dr.
Universitätsklinikum Jena
Recruiting
Jena, Germany, 07747
Contact: Inken Hilgendorf, PD Dr. Inken.Hilgendorf@med.uni-jena.de
Principal Investigator: Inken Hilgendorf, PD Dr.
Sub-Investigator: Nils Winkelmann, Dr.
University Hospital Leipzig
Recruiting
Leipzig, Germany, 04103
Contact: Dietger Niederwieser, Prof. Dr. Dietger.Niederwieser@medizin.uni-leipzig.de
Principal Investigator: Dietger Niederwieser, Prof. Dr.
Sub-Investigator: Vladan Vucinic, Dr.
Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Recruiting
Mainz, Germany, 55131
Contact: Eva Wagner, Dr. eva.wagner@unimedizin-mainz.de
Principal Investigator: Eva Wagner-Drouet, Dr.
Sub-Investigator: Thomas Kindler, PD Dr.
Universitätsmedizin Mannheim
Recruiting
Mannheim, Germany, 68167
Contact: Stefan Klein, PD Dr. Stefan.Klein@medma.uni-heidelberg.de
Principal Investigator: Stefan Klein, PD Dr.
Sub-Investigator: Andreas Reiter, Prof. Dr.
Johannes Wesling Klinikum Minden
Recruiting
Minden, Germany, 32429
Contact: Martin Griesshammer, Prof. Dr. martin.griesshammer@muehlenkreiskliniken.de
Principal Investigator: Martin Griesshammer, Prof. Dr.
Sub-Investigator: Hans-Joachim Tischler, Dr.
Universitätsklinikum Münster
Recruiting
Munster, Germany, 48149
Contact: Matthias Stelljes, Prof. Dr. Matthias.Stelljes@ukmuenster.de
Principal Investigator: Eva Eßeling, Dr.
Sub-Investigator: Matthias Stelljes, Prof. Dr.
Klinikum Nürnberg
Recruiting
Nürnberg, Germany, 90419
Contact: Kerstin Schäfer-Eckart, Dr. Kerstin.Schaefer-Eckart@klinikum-nuernberg.de
Principal Investigator: Kerstin Schäfer-Eckart, Dr.
Sub-Investigator: Knut Wendelin, Dr,
Robert-Bosch-Krankenhaus Stuttgart
Recruiting
Stuttgart, Germany, 70376
Contact: Martin Kaufmann, Dr. Martin.Kaufmann@rbk.de
Principal Investigator: Martin Kaufmann, Dr.
Sub-Investigator: Matthias Vöhringer, Dr.
Universitätsmedizin Tübingen
Recruiting
Tübingen, Germany, 72076
Contact: Wolfgang Bethge, Prof. Dr. Wolfgang.Bethge@med.uni-tuebingen.de
Principal Investigator: Wolfgang Bethge, Prof. Dr.
Sub-Investigator: Christoph Faul, Dr.
Universitätsklinkum Ulm
Recruiting
Ulm, Germany, 89081
Contact: Konstanze Döhner, Prof. Dr. Konstanze.Doehner@uniklinik-ulm.de
Principal Investigator: Konstanze Döhner, Prof. Dr.
Sub-Investigator: Frank Stegelmann, Dr. 收起 <<
Terminated(The safety committe... 展开 >>e found no safety issues but recommended halting the study based on a lack of efficacy in a similar trial. The sponsor terminated the trial.) 收起 <<
United States, Missouri
... 展开 >>
Washington University School of Medicine
Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Stephen Oh, M.D., Ph.D. 314-747-7960 stoh@wustl.edu
Principal Investigator: Stephen Oh, M.D., Ph.D.
Sub-Investigator: Amy Zhou, M.D. 收起 <<
United States, Florida
... 展开 >>
Winter Park, Florida, United States, 32789
United States, Maryland
Baltimore, Maryland, United States, 21229
United States, Texas
Houston, Texas, United States, 77030
Austria
Vienna, Austria
China, Jiangsu
Nanjing, Jiangsu, China
China, Sichuan
Chengdu, Sichuan, China
China, Zhejiang
Hangzhou, Zhejiang, China
China
Beijing, China
France
Angers, France
Paris, France
Pierre-Benite, France
Germany
Leipzig, Germany
Italy
Firenze, Italy
Milano, Italy
Terni, Italy
Netherlands
Rotterdam, Netherlands
United Kingdom
Belfast, United Kingdom
London, United Kingdom 收起 <<
United States, California
... 展开 >>
City of Hope Medical Center
Recruiting
Duarte, California, United States, 91010
Contact: Haris Ali 626-256-4673
Principal Investigator: Haris Ali 收起 <<
United States, Connecticut
... 展开 >>
Yale Cancer Center
Recruiting
New Haven, Connecticut, United States, 06511
Contact: Kris Awerkamp, BSN RN CCRP 602-358-8319 kawerkamp@td2inc.com
Principal Investigator: Nikolai Podoltsev, MD PhD
United States, Louisiana
Ochsner Clinic Foundation
Recruiting
New Orleans, Louisiana, United States, 70121
Contact: Kris Awerkamp, BSN, RN 602-358-8319 kawerkamp@td2inc.com
Principal Investigator: Laura Finn, MD
United States, Michigan
University of Michigan
Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Kris Awerkamp, BSN, RN 602-358-8319 kawerkamp@td2inc.com
Principal Investigator: Moshe Talpaz, MD
Karmanos Cancer Institute
Recruiting
Detroit, Michigan, United States, 48201
Contact: Kris Awerkamp, BSN, RN 602-358-8319 kawerkamp@td2inc.com
Principal Investigator: Jay Yang, MD
United States, Nebraska
University of Nebraska Medical Center
Recruiting
Omaha, Nebraska, United States, 68198
Contact: Kris Awerkamp, BSN, RN 602-358-8319 kawerkamp@td2inc.com
Principal Investigator: Krishna Gundabolu, MD
United States, North Carolina
Duke University Medical Center
Recruiting
Durham, North Carolina, United States, 27710
Contact: Kris Awerkamp, BSN RN CCRP 602-358-8319 kawerkamp@td2inc.com
Principal Investigator: Murat Arcasoy, MD
United States, Ohio
Cleveland Clinic - Taussig Cancer Institute
Recruiting
Cleveland, Ohio, United States, 44195
Contact: Kris Awerkamp, BSN RN CCRP 602-358-8319 kawerkamp@td2inc.com
Principal Investigator: Moshe Talpaz, MD
United States, Pennsylvania
Abramson Cancer Center - University of Pennsylvania
Recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact: Kris Awerkamp, BSN, RN 602-358-8319 kawerkamp@td2inc.com
Principal Investigator: Elizabeth Hexner, MD
United States, Texas
MD Anderson Cancer Center
Recruiting
Houston, Texas, United States, 77030
Contact: Kris Awerkamp, BSN, RN 602-358-8319 kawerkamp@td2inc.com
Principal Investigator: Naveen Pemmaraju, MD
Mays Cancer Center UT Health San Antonio
Recruiting
San Antonio, Texas, United States, 78229-3900
Contact: Kris Awerkamp, BSN, RN, CCRP 602-358-8319 kawerkamp@td2inc.com
Principal Investigator: Ruben A. Mesa, MD, FACP 收起 <<
United States, California
... 展开 >>
Highland, California, United States, 92346
United States, Florida
Boynton Beach, Florida, United States, 33435
United States, New York
New York, New York, United States, 10011 收起 <<
United States, Alabama
... 展开 >>
Alabama CRS
Birmingham, Alabama, United States, 35294
United States, California
UCLA CARE Center CRS
Los Angeles, California, United States, 90035
UCSD Antiviral Research Center CRS
San Diego, California, United States, 92103
Ucsf Hiv/Aids Crs
San Francisco, California, United States, 94110
United States, Illinois
Northwestern University CRS
Chicago, Illinois, United States, 60611
United States, Missouri
Washington University Therapeutics (WT) CRS
Saint Louis, Missouri, United States, 63110-1010
United States, New York
Weill Cornell Chelsea CRS
New York, New York, United States, 10010
Weill Cornell Uptown CRS
New York, New York, United States, 10065
University of Rochester Adult HIV Therapeutic Strategies Network CRS
Rochester, New York, United States, 14642
United States, Ohio
Cincinnati Clinical Research Site
Cincinnati, Ohio, United States, 45219
Case Clinical Research Site
Cleveland, Ohio, United States, 44106
United States, Pennsylvania
Penn Therapeutics, CRS
Philadelphia, Pennsylvania, United States, 19104
United States, Rhode Island
The Miriam Hospital Clinical Research Site (TMH CRS) CRS
Providence, Rhode Island, United States, 02906
United States, Tennessee
Vanderbilt Therapeutics (VT) CRS
Nashville, Tennessee, United States, 37204 收起 <<
Russian Federation
... 展开 >>
First Pavlov State Medical University of St. Petersburg
Recruiting
Saint-Petersburg, Russian Federation, 197089
Contact: Ivan S. Moiseev, PhD +79217961951 moisiv@mail.ru
Contact: Boris V. Afanasyev, Prof +78122334551 coordinatorbmt@gmail.com 收起 <<
Terminated(The study was termi... 展开 >>nated as other related studies of ruxolitinib did not provide sufficient efficacy to warrant continuation.) 收起 <<
Blasts More Than 20 Percent of... 展开 >> Bone Marrow Nucleated Cells
Blasts More Than 20 Percent of Peripheral Blood White Cells
Myelodysplastic/Myeloproliferative Neoplasm
Recurrent Acute Myeloid Leukemia
Refractory Acute Myeloid Leukemia 收起 <<
Phase 1
Phase 2
Recruiting
February 1, 2019
United States, Texas
... 展开 >>
M D Anderson Cancer Center
Recruiting
Houston, Texas, United States, 77030
Contact: Farhad Ravandi-Kashani 713-745-0394
Principal Investigator: Farhad Ravandi-Kashani 收起 <<
Germany
... 展开 >> Charité - Universitätsmedizin Berlin
Recruiting
Berlin, Germany, 13353
Principal Investigator: Igor Blau, PD Dr.
Sub-Investigator: Il-Kang Na, PD Dr.
Sub-Investigator: Giang Lam Vuong, Dr.
Universitätsklinikum Bonn
Recruiting
Bonn, Germany, 53105
Principal Investigator: Dominik Wolf, Prof.
Sub-Investigator: Karin Mayer, Dr.
Universitätsklinikum Dresden
Recruiting
Dresden, Germany, 01307
Principal Investigator: Friedrich Stölzel, Dr.
Sub-Investigator: Rainer Ordemann, Prof.
University Medical Center
Recruiting
Freiburg, Germany, 79106
Contact: Nikolas von Bubnoff, Professor nikolas.bubnoff@uniklinik-freiburg.de
Principal Investigator: Nikolas von Bubnoff, Professor
Sub-Investigator: Robert Zeiser, Professor
Universitätsklinikum Hamburg Eppendorf
Recruiting
Hamburg, Germany, 20246
Principal Investigator: Francis Ayuk, PD Dr.
Sub-Investigator: Dietlinde Janson, Dr.
Universitätsklinikum Heidelberg
Recruiting
Heidelberg, Germany, 69120
Principal Investigator: Peter Dreger, Prof.
Sub-Investigator: Thomas Luft, PD Dr.
Universitätsklinikum des Saarlandes
Recruiting
Homburg, Germany, 66421
Contact: Jörg T. Bittenbring, Dr.
Principal Investigator: Jörg T. Bittenbring, Dr.
Sub-Investigator: Niels Murawski, PD Dr.
Universitätsklinikum Köln
Recruiting
Köln, Germany, 50937
Contact: Udo Holtick, Dr.
Principal Investigator: Udo Holtick, Dr.
Sub-Investigator: Christof Scheid, Prof.
Sub-Investigator: Marco Herling, Dr.
Universitätsklinikum Marburg
Recruiting
Marburg, Germany, 35043
Contact: Andreas Burchert, Prof.
Principal Investigator: Andreas Burchert, Prof.
Sub-Investigator: Kristina Sohlbach, Dr.
Universitätsklinikum München TU rechts der Isar
Recruiting
München, Germany, 81675
Principal Investigator: Mareike Verbeek, Dr.
Sub-Investigator: Sandra Grass, Dr.
Universitätsklinikum Würzburg
Recruiting
Würzburg, Germany, 97080
Principal Investigator: Götz Grigoleit, Dr.
Sub-Investigator: Sabrina Kraus, Dr. 收起 <<
United States, Arizona
... 展开 >>
Arizona Oncology Associates
Recruiting
Tempe, Arizona, United States, 85284
Contact: Study Coordinator 480-256-1664
Principal Investigator: Kasra Karamlou
United States, California
UC Irvine Medical Center
Recruiting
Orange, California, United States, 92868
Contact: Study Coordinator 714-456-5408
Principal Investigator: Angela Fleischman, MD
United States, Colorado
Anschutz Cancer Pavilion - University Of Colorado
Recruiting
Aurora, Colorado, United States, 80045
Contact: Study Coordinator 720-848-2587
Principal Investigator: Brandon McMahon
United States, Connecticut
Norwalk Hospital
Recruiting
Norwalk, Connecticut, United States, 06856
Contact: Study Coordinator 203-852-2996
Principal Investigator: Richard Frank
United States, District of Columbia
Georgetown University Hospital
Not yet recruiting
Washington, District of Columbia, United States, 20007
Contact: Study Coordinator 202-687-0116
Principal Investigator: Craig Kessler
United States, Indiana
Parkview Research Center
Recruiting
Fort Wayne, Indiana, United States, 46845
Contact: Study Coordinator 260-425-6831
Principal Investigator: Robert Manges
United States, Maryland
University Of Maryland - Greenebaum Cancer Center
Recruiting
Baltimore, Maryland, United States, 21201
Contact: Study Coordinator 410-328-6635
Principal Investigator: Duong
United States, Michigan
University of Michigan Health System
Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Study Coordinator 734-936-3879
Principal Investigator: Moshe Talpaz, MD
Karmanos Cancer Institute
Recruiting
Detroit, Michigan, United States, 48201
Contact: Study Coordinator 313-576-9758
Principal Investigator: Jay Yang
Providence Cancer Center
Recruiting
Southfield, Michigan, United States, 48075
Contact: Study Coordinator 248-849-5332
Principal Investigator: Howard Terebelo
United States, New Mexico
University Of New Mexico Cancer Center
Recruiting
Albuquerque, New Mexico, United States, 87102
Contact: Study Coordinator 505-925-0379
Principal Investigator: Arana Yi
United States, New York
Weill Cornell Medical Centers
Not yet recruiting
New York, New York, United States, 10065
Contact: Study Coordinator 212-746-2389
Principal Investigator: Ellen Ritchie
New York Medical College
Not yet recruiting
Valhalla, New York, United States, 10595
Contact: Study Coordinator 914-493-8375
Principal Investigator: Karen Seiter
United States, North Carolina
Duke University Medical Center
Not yet recruiting
Durham, North Carolina, United States, 27710
Contact: Study Coordinator 919-681-4769
Principal Investigator: Murat Arcasoy
United States, Ohio
Cleveland Clinic
Recruiting
Cleveland, Ohio, United States, 44195
Contact: Study Coordinator 216-444-9464
Principal Investigator: Aaron Gerds, MD
United States, Oregon
Willamette Valley Cancer Institute
Recruiting
Eugene, Oregon, United States, 97401
Contact: Study Coordinator 281-863-4631
Principal Investigator: Jeff Sharman, MD
United States, Texas
Texas Oncology San Antonio
Recruiting
San Antonio, Texas, United States, 78240
Contact: Study Coordinator 210-595-5680
Principal Investigator: Roger Lyons
Texas Oncology - Tyler
Recruiting
Tyler, Texas, United States, 75702
Contact: Study Coordinator 903-579-9800
Principal Investigator: Habte Yimer
United States, Virginia
University of Virginia
Recruiting
Charlottesville, Virginia, United States, 22908
Contact: Study Coordinator 434-982-3927
Principal Investigator: Michael Keng, MD 收起 <<
Terminated(According to the pr... 展开 >>otocol, the sponsor terminated the study after it was determined that less than 2 of the first 22 patients showed a PSA50 response.) 收起 <<
-
United States, California
... 展开 >>
Highland, California, United States
Montebello, California, United States
Mountain View, California, United States
United States, Illinois
Galesburg, Illinois, United States
United States, Kansas
Overland Park, Kansas, United States
Wichita, Kansas, United States
United States, Michigan
Grand Rapids, Michigan, United States
United States, Missouri
Jefferson City, Missouri, United States
United States, Montana
Great Falls, Montana, United States, 59405
United States, New Jersey
Cherry Hill, New Jersey, United States
United States, New York
Staten Island, New York, United States
United States, North Dakota
Bismarck, North Dakota, United States
United States, Pennsylvania
Bethlehem, Pennsylvania, United States
United States, South Carolina
Sumter, South Carolina, United States
United States, Washington
Lacey, Washington, United States 收起 <<
Recurrent Diffuse Large B-Cell... 展开 >> Lymphoma
Recurrent Mature T- and NK-Cell Non-Hodgkin Lymphoma
Refractory Diffuse Large B-Cell Lymphoma
Refractory Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma 收起 <<
Phase 2
Active, not recruiting
December 2019
United States, Maryland
... 展开 >>
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
United States, Minnesota
Mayo Clinic
Rochester, Minnesota, United States, 55905
United States, Nebraska
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198 收起 <<
United States, California
... 展开 >>
Stanford Hospital and Clinics
Stanford, California, United States, 94305
United States, Michigan
University of Michigan Health System
Ann Arbor, Michigan, United States, 48109 收起 <<
Pancreatic Cancer
... 展开 >> Colorectal Cancer (CRC)
Breast Cancer
Lung Cancer 收起 <<
Phase 2
Enrolling by invitation
November 2019
United States, Kentucky
... 展开 >>
University of Louisville
Louisville, Kentucky, United States, 40202
United States, New York
New York Oncology Hematology PC
Hudson, New York, United States, 12534
United States, Texas
U of Texas M.D. Anderson Cancer Center
Houston, Texas, United States, 77030 收起 <<
United States, Missouri
... 展开 >>
Washington University of St. Louis
Saint Louis, Missouri, United States, 63110
United States, New York
Roswell Park Cancer Institute
Buffalo, New York, United States, 14263
Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10029
Columbia University Medical Center
New York, New York, United States, 10032
Memorial Sloan-Kettering Cancer Center
New York, New York, United States, 10065
United States, North Carolina
Wake Forest University Baptist Medical Center
Winston-Salem, North Carolina, United States, 27157
United States, Ohio
Cleveland Clinic Taussig Cancer Center Institute
Cleveland, Ohio, United States, 44195
United States, Pennsylvania
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104 收起 <<
Terminated(According to the pr... 展开 >>otocol, the sponsor terminated the study after it was determined that less than 2 of the first 22 patients showed a PSA50 response.) 收起 <<
Terminated(Not enough response... 展开 >>s to continue treatment.) 收起 <<
-
United States, Massachusetts
... 展开 >>
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215 收起 <<
United States, Florida
... 展开 >>
H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida, United States, 33612
United States, Maryland
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
Baltimore, Maryland, United States, 21287
United States, Massachusetts
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215
United States, New York
Weill Medical College of Cornell
New York, New York, United States, 10021
United States, Ohio
Cleveland Clinic
Cleveland, Ohio, United States, 44106 收起 <<
United States, Michigan
... 展开 >>
University of Michigan Comprehensive Cancer Center
Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Ryan Wilcox, M.D. 734-615-1482 rywilcox@umich.edu
Principal Investigator: Ryan Wilcox, M.D. 收起 <<
United States, Maryland
... 展开 >>
Johns Hopkins University
Recruiting
Baltimore, Maryland, United States, 21287
Contact: Vered Stearns, MD vstearn1@jhmi.edu
Johns Hopkins at Green Spring Station
Recruiting
Lutherville, Maryland, United States, 21093
Contact: Vered Stearns, MD Vstearn1@jhmi.edu
United States, Massachusetts
Dana-Farber Cancer Institute
Recruiting
Boston, Massachusetts, United States, 02215
Contact: Beth Overmoyer, MD, FACP 617-632-4056 bovermoyer@partners.org
Principal Investigator: Beth Overmoyer, MD, FACP
United States, Michigan
University of Michigan
Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Catherine Van Poznak, MD cvanpoz@med.umich.edu
United States, Minnesota
Mayo Clinic
Recruiting
Rochester, Minnesota, United States, 55905
Contact: Tufia Haddad, MD Haddad.Tufia@mayo.edu
United States, North Carolina
Duke University Medical Center
Recruiting
Durham, North Carolina, United States, 27710
Contact: Jeremy Force, MD Jeremy.force@duke.edu
United States, Pennsylvania
University of Pennslyvania
Recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact: Amy Clark, MD Clarkamy@mail.upenn.edu
United States, Texas
MD Anderson Cancer Center
Recruiting
Houston, Texas, United States, 77030
Contact: Naoto Ueno, MD Nueno@mdanderson.org 收起 <<
United States, Arizona
... 展开 >>
Scottsdale, Arizona, United States
United States, Florida
Winter Park, Florida, United States
United States, Texas
Houston, Texas, United States, TX 收起 <<
United States, New Jersey
... 展开 >>
Memoral Sloan Kettering Cancer Center
Basking Ridge, New Jersey, United States
United States, New York
Memorial Sloan Kettering Cancer Center @ Suffolk
Commack, New York, United States, 11725
Memorial Sloan Kettering West Harrison
Harrison, New York, United States, 10604
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Memorial Sloan Kettering at Mercy Medical Center
Rockville Centre, New York, United States
Memoral Sloan Kettering Cancer Center at Phelps
Sleepy Hollow, New York, United States, 10591 收起 <<
United States, California
... 展开 >>
Highland, California, United States
La Jolla, California, United States
Los Angeles, California, United States
United States, Florida
Jacksonville, Florida, United States
Orange City, Florida, United States
Winter Park, Florida, United States
United States, Georgia
Atlanta, Georgia, United States
Augusta, Georgia, United States
United States, Iowa
Iowa City, Iowa, United States
United States, Maryland
Baltimore, Maryland, United States
United States, Michigan
Ann Arbor, Michigan, United States
Southfield, Michigan, United States
United States, New Jersey
Morristown, New Jersey, United States
United States, New York
Armonk, New York, United States
United States, North Carolina
Hickory, North Carolina, United States
United States, Ohio
Canton, Ohio, United States
United States, Pennsylvania
Hazelton, Pennsylvania, United States
Hershey, Pennsylvania, United States
United States, South Carolina
Charleston, South Carolina, United States
United States, South Dakota
Sioux Falls, South Dakota, United States
United States, Texas
San Antonio, Texas, United States 收起 <<
United States, Florida
... 展开 >>
H. Lee Moffitt Cancer Center and Research Institute
Not yet recruiting
Tampa, Florida, United States, 33612
Contact: Anthony McLaughlin 813-745-5941 anthony.mclaughlin@moffitt.org
Contact: Kendra Sweet, M.D. 813-745-8986 kendra.sweet@moffitt.org
Principal Investigator: Kendra Sweet, M.D. 收起 <<
Acute Lymphoblastic Leukemia
... 展开 >> ALL, Childhood
ALL 收起 <<
Phase 1
Not yet recruiting
September 5, 2024
United States, Illinois
... 展开 >>
University of Chicago Medical Center
Not yet recruiting
Chicago, Illinois, United States, 60637
Contact: Howie Weiner 773-702-2084 hweiner@medicine.bsd.uchicago.edu
Contact: Peggy Green, RN (773) 702-0267 mgreen@medicine.bsd.uchicago.edu
Principal Investigator: Emily Currant, MD 收起 <<
United States, New Jersey
... 展开 >>
Memorial Sloan Kettering Monmouth
Recruiting
Middletown, New Jersey, United States, 07748
Contact: Raajit Rampal, MD, PhD 212-639-2194
United States, New York
Memorial Sloan Kettering Commack
Recruiting
Commack, New York, United States, 11725
Contact: Raajit Rampa, MD, PhD 212-639-2194
Memorial Sloan Kettering Westchester
Recruiting
Harrison, New York, United States, 10604
Contact: Raajit Rampal, MD, PhD 212-639-2194
Memorial Sloan Kettering Cancer Center
Recruiting
New York, New York, United States, 10065
Contact: Raajit Rampal, MD, PhD 212-639-2194
Contact: Ellin Berman, MD 212-639-7762
Principal Investigator: Raajit Rampal, MD, PhD
Memorial Sloan Kettering Rockville Centre
Recruiting
Rockville Centre, New York, United States, 11570
Contact: Raajit Rampal, MD, PhD 212-639-2194
United States, Texas
Md Anderson Cancer Center
Recruiting
Houston, Texas, United States, 77030
Contact: Prithvira Bose, MD 713-792-7747
Principal Investigator: Prithvira Bose, MD 收起 <<
United States, Michigan
... 展开 >>
University of Michgan Comprehensive Cancer Center
Recruiting
Ann Arbor, Michigan, United States, 48187
Contact: Tycel Phillips, M.D. 734-232-2883 tycelp@umich.edu
Principal Investigator: Tycel Phillips, M.D. 收起 <<
Metastatic Breast Cancer
... 展开 >> Breast Carcinoma
HER-2 Positive Breast Cancer 收起 <<
Phase 1
Phase 2
Recruiting
December 2018
United States, New York
... 展开 >>
Mount Sinai Medical Center
Recruiting
New York, New York, United States, 10029
Contact: Amy Tiersten, MD 212-241-2299 amy.tiersten@mssm.edu
Principal Investigator: Amy Tiersten, MD
Columbia University Medical Center
Recruiting
New York, New York, United States, 10032
Contact: Kevin Kalinsky, MD, MS 212-305-1945 KK2693@cumc.columbia.edu
Contact: Dan Otap, CCRP 212-342-3970 DO2267@cumc.columbia.edu
Principal Investigator: Kevin Kalinsky, MD, MS
New York Hospital-Weill Cornell Medical Center
Recruiting
New York, New York, United States, 10065
Contact: Tessa Cigler, MD 212-821-0644 elc2007@med.cornell.edu
Principal Investigator: Tessa Cigler, MD
Montefiore Medical Center
Recruiting
New York, New York, United States, 10461
Contact: Della Makower, MD 718-405-8529 dmakower@montefiore.org
Principal Investigator: Della Makower, MD 收起 <<
United States, Massachusetts
... 展开 >>
Dana Farber Cancer Institute
Not yet recruiting
Boston, Massachusetts, United States, 02214
Contact: Zachariah DeFilipp, MD 617-724-4000 zdefilipp@mgh.harvard.edu
Principal Investigator: Zachariah DeFilipp, MD 收起 <<
United States, Alabama
... 展开 >>
UAB Comprehensive Cancer Cente /ID# 165464
Recruiting
Birmingham, Alabama, United States, 35217
United States, California
Ucsd /Id# 164084
Recruiting
La Jolla, California, United States, 92037
Usc /Id# 164095
Recruiting
Los Angeles, California, United States, 90033
United States, Florida
Mayo Clinic /ID# 164201
Recruiting
Jacksonville, Florida, United States, 32224
Moffitt Cancer Center /ID# 164082
Recruiting
Tampa, Florida, United States, 33612
United States, Illinois
University of Chicago /ID# 164115
Recruiting
Chicago, Illinois, United States, 60637
United States, Indiana
Indiana Blood & Marrow Transpl /ID# 165075
Recruiting
Indianapolis, Indiana, United States, 46237
United States, Massachusetts
Dana-Farber Cancer Institute /ID# 162675
Recruiting
Boston, Massachusetts, United States, 02215
United States, Michigan
Henry Ford Hospital /ID# 162682
Recruiting
Detroit, Michigan, United States, 48202
United States, New York
Weill Cornell Medical College /ID# 162679
Recruiting
New York, New York, United States, 10021
United States, Texas
MD Anderson Cancer Center /ID# 162683
Recruiting
Houston, Texas, United States, 77030
UT Health Cancer Center /ID# 164094
Recruiting
San Antonio, Texas, United States, 78229
United States, Utah
University of Utah /ID# 164116
Recruiting
Salt Lake City, Utah, United States, 84112-5500
United Kingdom
Guy's and St Thomas' NHS Found /ID# 164110
Recruiting
London, London, City Of, United Kingdom, SE1 9RT
Christie NHS Foundation Trust /ID# 164111
Recruiting
Manchester, United Kingdom, M20 4BX 收起 <<
United States, Florida
... 展开 >>
San Marcus Research Clinic Inc
Recruiting
Miami, Florida, United States, 33015
Well Pharma Medical Research Corporation
Not yet recruiting
Miami, Florida, United States, 33143
Forward Clinical Trials Inc
Not yet recruiting
Tampa, Florida, United States, 33624
United States, Georgia
Clinical Research Atlanta
Not yet recruiting
Stockbridge, Georgia, United States, 30281
United States, Kentucky
Derm Research LLC
Not yet recruiting
Louisville, Kentucky, United States, 40217
Dermatology Specialists PSC
Not yet recruiting
Louisville, Kentucky, United States, 40241
United States, New Hampshire
ActivMed Practices & Research Inc
Not yet recruiting
Portsmouth, New Hampshire, United States, 03801
United States, New Jersey
Hassman Research Institute
Not yet recruiting
Berlin, New Jersey, United States, 08009
United States, Ohio
Synexus Clinical Research US, Inc. - Cincinnati
Not yet recruiting
Cincinnati, Ohio, United States, 45236
United States, Pennsylvania
Paddington Testing Company Inc
Not yet recruiting
Philadelphia, Pennsylvania, United States, 19103
United States, South Carolina
Synexus Clinical Research US, Inc. - Anderson
Not yet recruiting
Anderson, South Carolina, United States, 29621
United States, Texas
Clinical Trials of Texas Incorporated
Not yet recruiting
San Antonio, Texas, United States, 78229
Center for Clinical Studies
Not yet recruiting
Webster, Texas, United States, 77598
United States, Virginia
Clinical Research Partners LLC
Not yet recruiting
Henrico, Virginia, United States, 23233
United States, Washington
Dermatology Specialists of Spokane
Not yet recruiting
Spokane, Washington, United States, 99204 收起 <<
Head and Neck Squamous Cell Ca... 展开 >>rcinoma 收起 <<
Phase 2
Not yet recruiting
September 29, 2020
United States, Arizona
... 展开 >>
University of Arizona Cancer Center
Not yet recruiting
Tucson, Arizona, United States, 85724
Contact: Clinical Trials Office 866-278-1554 UACC-C3@uacc.arizona.edu
Sub-Investigator: Julie Bauman, MD
United States, California
UCSF Helen Diller Family Comprehensive Cancer Center
Not yet recruiting
San Francisco, California, United States, 94131
Contact: Kyusun Cha, CCRC 415-502-3081 Kyusun.Cha@ucsf.edu 收起 <<
United States, Michigan
... 展开 >>
The University of Michigan Comprehensive Cancer Center
Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Patrick Burke, M.D. 734-647-8921 pwburke@umich.edu
Principal Investigator: Patrick Burke, M.D.
United States, North Carolina
Wake Forest University Health Sciences
Not yet recruiting
Winston-Salem, North Carolina, United States, 27157
Contact: Rupali Bhave, M.D. 336-713-0864 rbhave@wakehealth.edu
Contact: Megan Brown-Farmer 336-713-6913 mebrown@wakehealth.edu 收起 <<
United States, Florida
... 展开 >>
Blood & Marrow Transplant Center
Orlando, Florida, United States, 32804
Principal Investigator: Dr. Steven Goldstein
United States, Kansas
Cancer Center of Kansas
Wichita, Kansas, United States, 67214
Principal Investigator: Dr. Shaker Dakhil
United States, Massachusetts
Massachusetts General Hospital
Boston, Massachusetts, United States, 02215
Principal Investigator: Dr. Yin-Bin Chen
United States, Michigan
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, United States, 48109-5271
Principal Investigator: Dr. Sarah Anand
United States, New Jersey
Hackensack University Medical Center
Hackensack, New Jersey, United States, 07601
Principal Investigator: Dr. Alfred Gillio
United States, New York
Weill Cornell Medical College
New York, New York, United States, 10021
Principal Investigator: Dr. Tsiporah Shore
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Principal Investigator: Dr. Miguel-Angel Perales
United States, Oregon
Oregon Health & Science University
Portland, Oregon, United States, 97239
Principal Investigator: Dr. Rachel Cook
United States, Pennsylvania
Gettysburg Cancer Center
Gettysburg, Pennsylvania, United States, 17325
Principal Investigator: Dr. Satish Shah
Allegheny Health Network Cancer Institute
Pittsburgh, Pennsylvania, United States, 15224
Principal Investigator: Dr. Anna Koget
United States, South Carolina
Greenville Health System Cancer Institute
Greenville, South Carolina, United States, 29615
Principal Investigator: Dr. Suzanne Fanning
United States, South Dakota
Avera Research Institute
Sioux Falls, South Dakota, United States, 57105
Principal Investigator: Dr. Vinod Parameswaran
United States, Texas
Medical City Dallas Hospital
Dallas, Texas, United States, 75230
Principal Investigator: Dr. Vikas Bhushan
United States, Washington
Fred Hutchinson Cancer Research Center
Seattle, Washington, United States, 98109-1024
Principal Investigator: Dr. Paul Carpenter
United States, Wisconsin
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Principal Investigator: Dr. Parameswaran Hari 收起 <<
United States, California
... 展开 >>
Comprehensive Blood and Cancer Center
Recruiting
Bakersfield, California, United States, 93309-0633
Contact: Nicole Henry 661-862-8548 nhenry@cbccusa.com
Principal Investigator: Ravindranath Patel, MD
California Cancer Associates for Research & Excellence (cCARE)
Recruiting
Encinitas, California, United States, 92024
Contact: Daniela Slavin, PhD 760-452-3909 dslavin@ccare.com
Principal Investigator: Alberto Bessudo, MD
Robert A. Moss, M.D., F.A.C.P., Inc.
Recruiting
Fountain Valley, California, United States, 92708
Contact: Helen Tam 714-641-1128 helen.tam@sbcglobal.net
Principal Investigator: Robert A Moss, MD
Pacific Cancer Care
Recruiting
Monterey, California, United States, 93940
Contact: Dorothy Tenney 831-375-4105 dtenney@pacificcancercare.com
Principal Investigator: Laura Stampleman, MD
Sansum Clinic- Ridley-Tree Cancer Center
Recruiting
Santa Barbara, California, United States, 93105
Contact: Heidi Heitkamp, PhD 805-879-5091 hheitkam@ridleytreecc.org
Principal Investigator: Daniel R Greenwald, MD
James R. Berenson M.D. Inc.
Recruiting
West Hollywood, California, United States, 90069
Contact: Regina Swift, R.N 310-623-1227 rswift@berensononcology.com
Principal Investigator: James R Berenson, MD
United States, Florida
Millennium Oncology Research Clinic
Recruiting
Pembroke Pines, Florida, United States, 33024
Contact: Maria Contreras, MD 954-266-7885 mcontreras@millenniumoncologyfl.com
Principal Investigator: Isaac Levy, MD
United States, Maryland
Regional Cancer Care Associates (RCCA) MD, LLC
Recruiting
Bethesda, Maryland, United States, 20817
Contact: Natalie Bongiorno, RN 301-571-2016 nbongiorno@regionalcancercare.org
Principal Investigator: Ralph Boccia, MD 收起 <<
Primary Myelofibrosis
... 展开 >> Post Polycythemia Vera Myelofibrosis
Post Essential Thrombocythemia Myelofibrosis 收起 <<
Phase 2
Active, not recruiting
February 2021
United States, Georgia
... 展开 >>
Emory Hospital
Atlanta, Georgia, United States, 30322
United States, Illinois
Northwestern University, Robert h. Lurie Comprehensive Cancer Center
Chicago, Illinois, United States, 60611
United States, Kansas
University of Kansas Cancer Center
Westwood, Kansas, United States, 66205
United States, New York
Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10029
United States, North Carolina
Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, United States, 27103
United States, Ohio
Ohio State University
Columbus, Ohio, United States, 43210
Canada
Princess Margaret Cancer Centre, University of Toronto
Toronto, Canada, M5G 2M9
United Kingdom
University of Oxford
Oxford, United Kingdom, OX3 9DS 收起 <<
United States, Nebraska
... 展开 >>
University of Nebraska Medical Center
Recruiting
Omaha, Nebraska, United States, 68198
Contact: Penny Nurse Coordinator, RN 402-559-4596 收起 <<
United States, Ohio
... 展开 >>
Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center
Recruiting
Cleveland, Ohio, United States, 44195
Contact: Manmeet Ahluwalia, MD 866-223-8100 CancerCenterResearch@ccf.org
Principal Investigator: Manmeet Ahluwalia, MD 收起 <<
United States, Arizona
... 展开 >>
Mayo Clinic - Arizona
Recruiting
Phoenix, Arizona, United States, 85054
Contact: Clinical Trials Office 855-776-0015
Principal Investigator: Ruben Mesa, MD
United States, Colorado
University of Colorado Cancer Center
Recruiting
Aurora, Colorado, United States, 80045
Contact: Clinical Trials Office 720-848-0018
Principal Investigator: Daniel A Pollyea, MD, MS
United States, Tennessee
Vanderbilt-Ingram Cancer Center
Recruiting
Nashville, Tennessee, United States, 37232
Contact: Clinical Trials Office 800-811-8480
Principal Investigator: Michael R Savona, MD
United States, Wisconsin
Medical College of Wisconsin
Recruiting
Milwaukee, Wisconsin, United States, 53226
Contact: Clinical Trials Office 414-805-1118
Principal Investigator: Laura C. Michaelis, MD 收起 <<
United States, Massachusetts
... 展开 >>
Beth Israel Deaconess Medical Center
Recruiting
Boston, Massachusetts, United States, 02115
Contact: Myrna Nahas, MD 617-667-9920
Principal Investigator: Myrna Nahas, MD
Massachusetts General Hospital
Recruiting
Boston, Massachusetts, United States, 02115
Contact: Gabriella Hobbs, MD 617-726-8748
Principal Investigator: Gabriella Hobbs, MD
United States, Missouri
Washington University
Recruiting
Saint Louis, Missouri, United States, 63130
Contact: Mark Schroeder, MD markschroeder@wustl.edu
Principal Investigator: Mark Schroeder, MD
United States, Ohio
The Ohio State University
Recruiting
Columbus, Ohio, United States, 43210
Contact: Sumithira Vasu, MBBS Sumithira.Vasu@osumc.edu
Principal Investigator: Sumithira Vasu, MBBS
United States, Tennessee
Vanderbilt University
Recruiting
Nashville, Tennessee, United States, 37235
Contact: Michael Byrne, MD Michael.Byrne@vanderbilt.edu
Principal Investigator: Michael Byrne, MD 收起 <<
Malignant Neoplasms Stated as ... 展开 >>Primary Lymphoid Haematopoietic
Other Diseases of Blood and Blood-Forming Organs
Chronic Lymphocytic Leukemia
Small Lymphocytic Lymphoma 收起 <<
Phase 2
Recruiting
March 2021
United States, Texas
... 展开 >>
University of Texas MD Anderson Cancer Center
Recruiting
Houston, Texas, United States, 77030
Contact zestrov@mdanderson.org 收起 <<
United States, Massachusetts
... 展开 >>
Massachusetts General Hospital
Recruiting
Boston, Massachusetts, United States, 02214
Contact: Meridith E. Bailey, MD 617-643-4970 mebailey@partners.org
Principal Investigator: Gabriela Hobbs, MD
United States, Tennessee
Vanderbilt University
Recruiting
Nashville, Tennessee, United States, 37235
Contact: Michael Byrne, DO Michael.Byrne@vanderbilt.edu
Principal Investigator: Michael Byrne, DO 收起 <<
United States, Florida
... 展开 >>
H. Lee Moffitt Cancer Center and Research Institute
Not yet recruiting
Tampa, Florida, United States, 33612
Contact: Anthony McLaughlin 813-745-5941 Anthony.McLaughlin@moffitt.org
Principal Investigator: Eric Padron, MD
Sub-Investigator: Rami Komrokji, MD
Sub-Investigator: Alan F List, MD
Sub-Investigator: Jeffrey E Lancet, MD
Sub-Investigator: Kendra Sweet, MD
Sub-Investigator: Bijal Shah, MD
Sub-Investigator: David Sallman, MD
Sub-Investigator: Chetasi Talati, MD
Sub-Investigator: Andrew Kuykendall, MD
Sub-Investigator: Maria Balasis, BS
Sub-Investigator: Brooke Fridley, PhD 收起 <<
Ductal Carcinoma In Situ
... 展开 >> Atypical Lobular Hyperplasia
Atypical Ductal Hyperplasia
Lobular Carcinoma In Situ 收起 <<
Phase 2
Recruiting
January 2020
United States, Texas
... 展开 >>
Baylor College of Medicine
Recruiting
Houston, Texas, United States, 77030
Contact: Kristen Otte 713-798-8874 clinical-research@breastcenter.tmc.edu
Principal Investigator: Julie Nangia, M.D.
Sub-Investigator: Mothaffar Rimawi, M.D.
Sub-Investigator: Matthew Ellis, M.D.
Sub-Investigator: Maryam Nemati Shaefee, M.D.
Sub-Investigator: C. Kent Osborne, M.D.
Sub-Investigator: Angela Coscio, M.D. 收起 <<
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