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/ Procarbazine/甲基苄肼

Procarbazine/甲基苄肼 {[allProObj[0].p_purity_real_show]}

货号：A127242

Procarbazine is a chemotherapy medication used for the treatment of Hodgkin's lymphoma and brain cancers.

Procarbazine/甲基苄肼 化学结构 CAS号：671-16-9
Procarbazine/甲基苄肼 化学结构
CAS号：671-16-9
Procarbazine/甲基苄肼 3D分子结构
CAS号：671-16-9
Procarbazine/甲基苄肼 化学结构 CAS号：671-16-9
Procarbazine/甲基苄肼 3D分子结构 CAS号：671-16-9
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Procarbazine/甲基苄肼 纯度/质量文件 产品仅供科研

货号：A127242 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 MAO ↓ MAO-A ↓ MAO-B ↓ 其他靶点 纯度
Sennoside A ++

MAO, IC50: 17 μM

 		98%+
Glycyrrhizic acid ++++

MAO, IC50: 0.16 μM

 		80% HPLC
Rasagiline ++++

MAO-A, IC50: 412 nM

 		++++

MAO-B, IC50: 4.43 nM

 		97%
Isatin ++

MAO, IC50: 15 μM

 		+

MAO-A, IC50: 58 μM

 		++

MAO-B, IC50: 14 μM

 		98%
Paeonol +

MAO-A, IC50: 54.6 μM

 		+

MAO-B, IC50: 42.5 μM

 		98%
Tranylcypromine HCl +++

MAO-A, IC50: 11.5 μM

 		+++

MAO-B, IC50: 7 μM

 		97%
Moclobemide +++

MAO-A (5-HT), IC50: 6.1 μM

 		99%+
Pargyline HCl ++

MAO-A, Ki: 13 μM

 		+++

MAO-B, Ki: 0.5 μM

 		99%+
Safinamide ++++

MAO-B, IC50: 98 nM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Procarbazine/甲基苄肼 生物活性

描述 Procarbazine is a chemotherapy medication used for the treatment of Hodgkin's lymphoma and brain cancers.

Procarbazine/甲基苄肼 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00431561 Glioblastoma ... 展开 >>Anaplastic Astrocytoma 收起 << Phase 2 Completed - Austria ... 展开 >> Universitätsklinik Innsbruck; Abteilung für Neurochirurgie Innsbruck, Austria, 6020 Landes-Nervenklinik Wagner-Jauregg Linz, Austria, 4020 Kaiser Franz Josef Spital, Abteilung für Neurologie Wien, Austria, 1100 Georgia Sarajishvili Institute of Clinical Neurology and Neurosurgery Tbilisi, Georgia, 0114 Germany Medizinische Klinik und Poliklinik mit Schwerpunkt Onkologie und Hämatologie, Charité Campus Mitte Berlin, Germany, 10117 Klinik und Poliklinik für Neurologie Cottbus, Germany, 03048 Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden Dresden, Germany, 01307 Universitätsklinikum Gießen, Neurochirurgische Universitätsklinik Gießen, Germany, 35392 Universitätsklinikum Kiel, Klinik für Neurochirurgie Kiel, Germany, 24106 Universitätsklinikum Leipzig, Klinik und Poliklinik für Neurochirurgie Leipzig, Germany, 04103 Universitätsklinik Magdeburg, Klinik für Neurochirurgie Magdeburg, Germany, 39120 Universitätskliniken Mainz, Neurochirurgische Klinik und Poliklinik Mainz, Germany, 55131 Universitätsklinikum Münster, Klinik und Poliklinik für Neurochirurgie Münster, Germany, 48149 Klinikum und Poliklinik für Neurologie, Universität Regensburg Regensburg, Germany, 93053 Klinikum Saarbrücken, Neurochirurgie Saarbrücken, Germany, 66119 Neurologische Universitätsklinik Tübingen Tübingen, Germany, 72076 India Department of Neurosurgery, Amrita Institute of Medical Sciences & Research Centre Cochin, Kerala, India, 682026 Sree Chitra Tirunal Institute for Medical Sciences & Technology, Department of Neurosurgery Trivandrum, Kerala, India, 695011 Manipal Hospital; Manipal Institute for Neurological Disorders Bangalore, India, 560017 Department of Neurosurgery, National Institute of Mental Health and Neurosciences Bangalore, India, 560029 Department of Medical Oncology, Nizam's Institute of Medical Sciences Hyderabad, India, 500082 Department of Neurosurgery, LTMG Hospital & LTM Medical College Mumbai, India, 400022 Department of Neurosurgery, Neurosciences Center New Dehli, India, 110029 Department of Neurological Sciences, Christian Medical College & Hospital Vellore, India, 632004 Israel Soroka Medical Center, Neurosurgery Department Beer Sheva, Israel Rambam Medical Center, Neurosurgery Department Haifa, Israel, 31096 Rabin Medical Center, Neurosurgery Department Petach Tikva, Israel, 49100 Russian Federation Sverdlovsk Regional Oncological Clinic Ekaterinburg, Russian Federation, 620036 Republican Clinical Hospital of Ministry of Health of Tatarstan Republic Kazan, Russian Federation, 420064 Burdenko Neurosurgery Research Institute Moscow, Russian Federation, 125047 Omsk State Medical Academy; State Educational Institution of Higher Professional Education Omsk, Russian Federation, 644099 State Institution of Healthcare, Samara Regional Clinical Hospital in the name of M.I. Kalinin Samara, Russian Federation, 443095 Polenov Neurosurgery Research Institute St. Petersburg, Russian Federation, 191104 Military Medical Academy named after I.S.M. Kirov, Neurosurgery Department St. Petersburg, Russian Federation, 194175 Medical Center "XXI century" St. Petersburg, Russian Federation, 194354 Tcheliabinsk Regional Clinical Hospital; State Medical Institution for Prophylaxis and Treatment Tcheliabinsk, Russian Federation, 454076 收起 <<
NCT00592111 Pediatric Hod... 展开 >>gkin's Disease 收起 << Phase 2 Completed - United States, New York ... 展开 >> Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 收起 <<
NCT00025064 Lymphoma Phase 2 Unknown - Ireland ... 展开 >> Our Lady's Hospital for Sick Children Dublin, Ireland, 12 United Kingdom Birmingham Children's Hospital Birmingham, England, United Kingdom, B4 6NH Bristol Royal Hospital for Children Bristol, England, United Kingdom, BS2 8BJ Addenbrooke's Hospital at Cambridge University Hospitals NHS Foundation Trust Cambridge, England, United Kingdom, CB2 2QQ Leeds Cancer Centre at St. James's University Hospital Leeds, England, United Kingdom, LS9 7TF Leicester Royal Infirmary Leicester, England, United Kingdom, LE1 5WW Royal Liverpool Children's Hospital, Alder Hey Liverpool, England, United Kingdom, L12 2AP Saint Bartholomew's Hospital London, England, United Kingdom, EC1A 7BE Great Ormond Street Hospital for Children NHS Trust London, England, United Kingdom, WC1N 3JH Meyerstein Institute of Oncology at University College of London Hospitals London, England, United Kingdom, WIT 3AA Central Manchester and Manchester Children's University Hospitals NHS Trust Manchester, England, United Kingdom, M27 4HA Newcastle Upon Tyne Hospitals NHS Trust Newcastle-Upon-Tyne, England, United Kingdom, NE7 7DN Queen's Medical Centre Nottingham, England, United Kingdom, NG7 2UH Oxford Radcliffe Hospital Oxford, England, United Kingdom, 0X3 9DU Children's Hospital - Sheffield Sheffield, England, United Kingdom, S10 2TH Southampton General Hospital Southampton, England, United Kingdom, SO16 6YD Royal Marsden NHS Foundation Trust - Surrey Sutton, England, United Kingdom, SM2 5PT Royal Belfast Hospital for Sick Children Belfast, Northern Ireland, United Kingdom, BT12 6BE Aberdeen Royal Infirmary Aberdeen, Scotland, United Kingdom, AB25 2ZN Royal Hospital for Sick Children Edinburgh, Scotland, United Kingdom, EH9 1LF Royal Hospital for Sick Children Glasgow, Scotland, United Kingdom, G3 8SJ 收起 <<

Procarbazine/甲基苄肼 参考文献

[1]Voter AF, Manthei KA, Keck JL. A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. J Biomol Screen. 2016 Jul;21(6):626-33.

[2]Weiden PL, Storb R, et al. Effect of six weekly transfusions on canine marrow grafts: tests for sensitization and abrogation of sensitization by procarbazine and antithymocyte serum. J Immunol. 1976 Jul;117(1):143-50.

Procarbazine/甲基苄肼 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.52mL

0.90mL

0.45mL

22.59mL

4.52mL

2.26mL

45.19mL

9.04mL

4.52mL

Procarbazine/甲基苄肼 技术信息

CAS号671-16-9
分子式C12H19N3O
分子量 221.3
SMILES Code O=C(NC(C)C)C1=CC=C(CNNC)C=C1
MDL No. MFCD00866411
别名
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

Tags: Procarbazine | 671-16-9 | DNA Alkylator/Crosslinker | anticancer activity | Cell Cycle/DNA Damage | DNA Alkylator/Crosslinker | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Procarbazine/甲基苄肼 纯度/质量文件 | Procarbazine/甲基苄肼 亚型比较 | Procarbazine/甲基苄肼 生物活性 | Procarbazine/甲基苄肼 临床数据 | Procarbazine/甲基苄肼 参考文献 | Procarbazine/甲基苄肼 实验方案 | Procarbazine/甲基苄肼 技术信息

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