There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Pargyline hydrochloride is an irreversible monoamine oxidase (MAO) inhibitor with Kis of 13 μM and 0.5 μM for MAO-A and MAO-B, respectively[2]. Pargyline (0.5-2 mM; 24-120 hours; LNCaP-LN3 cells) treatment inhibits the proliferation of prostate cancer cells in a time- and dose-dependent manner. Pargyline (0.5-2 mM; 24-48 hours; LNCaP-LN3 cells) treatment decreases S phase and increases the G1 phase in the cells in a dose-dependent manner. Pargyline (0.5 mM; 24 hours; LNCaP-LN3 cells) treatment increases the apoptotic cells. Pargyline (2 mM; 48 hours; LNCaP-LN3 cells) treatment induces an increase of cytochrome c and a decrease of caspase-3 in the cells, but does not lead to a change of BCL-2 expression[3]. Moreover, a low dose of pargyline injected directly into the brain lowered arterial pressure[4]. Pargyline decrease STEP (striatal-enriched protein tyrosine phosphatase) activity in the D. rerio brain, without affecting the level of the ptpn5 mRNA gene[5]. Pargyline (100 mg/kg) increased the concentration of cerebral noradrenaline dopamine and 5-hydroxytryptamine in the mouse[6].
Pargyline HCl/帕吉林盐酸盐 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Adult mouse cardiomyocytes
100 µM
2 hours
To assess the effect of MAO inhibition on ROS formation induced by high glucose (HG) and pro-inflammatory cytokine IL-1β. Results showed that pargyline treatment reduced ROS formation.
Cell Death Differ. 2018 Sep;25(9):1671-1685.
Mouse granulosa cells
1 µM
2 hours
To study the effect of MAO and SERT activity on 5-HT accumulation, results showed pargyline significantly increased 5-HT accumulation, while fluoxetine prevented this effect
Int J Mol Sci. 2022 Nov 27;23(23):14828.
Mouse granulosa cells
10 µM
2 hours
To study the effect of MAO activity on 5-HT accumulation, results showed pargyline significantly increased 5-HT accumulation in granulosa cells
Int J Mol Sci. 2022 Nov 27;23(23):14828.
Human iPSC-beta cells
5 µM
24 hours
To evaluate the protective effect of Pargyline against ER stress-induced apoptosis, results showed Pargyline decreased cell apoptosis.
Nat Metab. 2020 Sep;2(9):934-945.
Human stem cell-derived βcells
5 µM
24 hours
To evaluate the effect of Pargyline on human βcell metabolism, it was found that Pargyline partially increased glycolysis but did not improve glucose-stimulated insulin secretion.
Mol Metab. 2025 May;95:102115.
NIT-1 mouse βcell line
5-100 µM
24-48 hours
To investigate the effect of Pargyline on βcell metabolism, results showed that Pargyline partially mimicked the metabolic protection of genetic Rnls inhibition but not completely.
Mol Metab. 2025 May;95:102115.
Neonatal rat ventricular myocytes (NRVMs)
100 µM
48 hours
To assess the effect of MAO inhibition on ROS formation induced by high glucose (HG) and pro-inflammatory cytokine IL-1β. Results showed that pargyline treatment normalized ROS levels.
Cell Death Differ. 2018 Sep;25(9):1671-1685.
NOD.scid islet cells
2 μg/mL
5 hours
To evaluate the protective effect of Pargyline against ER stress-induced apoptosis, results showed Pargyline decreased caspase-3 activation.
Nat Metab. 2020 Sep;2(9):934-945.
Pargyline HCl/帕吉林盐酸盐 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Zebrafish (Danio rerio)
TPH2 deficiency model
Aquarium water administration
0.5 mg/L
72 hours continuous
To evaluate the effects of Pargyline on behavior, 5-HT and BDNF systems in zebrafish with TPH2 deficiency. Results showed that Pargyline increased brain 5-HT levels, decreased 5-HIAA levels, and affected the expression of BDNF-related genes.
Int J Mol Sci. 2021 Nov 27;22(23):12851
Mice
Wild-type Mice hippocampal slices
Hippocampal slice perfusion
1 µM
Single treatment, lasting 20 minutes
To investigate the effect of Pargyline (MAO-B inhibitor) on LTP impairment induced by mitovesicles from Ts2 mice. Results showed that pretreatment with Pargyline eliminated the ability of Ts2 mitovesicles to impair LTP.
Mol Neurodegener. 2024 Apr 14;19(1):34
Mice
MPTP-induced acute, subchronic, and chronic models of Parkinson’s disease
Intraperitoneal injection
10 mg/kg
Single administration
To test the protective effect of compounds on MPTP-induced striatal dopamine depletion and motor dysfunction, results showed significant protection of striatal dopamine content and restoration of motor function in animals
Mol Neurodegener. 2016 Jan 13;11:6
Zebrafish
Zebrafish novel tank test
Water exposure
10, 30, and 100 mg/L
Single administration, 20 minutes duration
Evaluate the effect of Pargyline on anxiety-like behavior in zebrafish. Results showed that Pargyline exhibited an anxiogenic-like effect only at the lowest tested concentration (10 mg/L) during the first 1 min of the test, with no significant effects at other concentrations or time points.
Front Pharmacol. 2021 May 13;12:669370
C57BL/KalwRij mice
5TGM1 model
Intraperitoneal injection
100 mg/kg
5 times per week for 30 days
To evaluate the effect of combination therapy of pargyline with bortezomib on tumor burden, a significant reduction in tumor burden was observed.
J Exp Clin Cancer Res. 2022 Feb 1;41(1):45
Mice
Akita diabetes model
Oral
25-50 mg/mL
Daily for 4 weeks
To evaluate the effect of Pargyline on glycemia and βcell function in Akita mice, results showed that Pargyline improved glycemia and partially preserved βcell function.
Mol Metab. 2025 May;95:102115.
NOD mice
Diabetic NOD Mice model
Oral
5 μg/ml
Continuous administration
To evaluate the protective effect of Pargyline on transplanted beta cells, results showed Pargyline treatment allowed transplanted beta cells to survive in diabetic mice, produce insulin and reverse hyperglycemia.
Nat Metab. 2020 Sep;2(9):934-945.
C57BL6/J mice
Streptozotocin (STZ)-induced type 1 diabetes model
Intraperitoneal injection
50 mg/kg
Once daily for 12 weeks
To assess the effect of MAO inhibition on cardiac function in diabetic mice. Results showed that pargyline treatment improved diastolic function, reduced cardiac fibrosis, and prevented mast cell degranulation.
Cell Death Differ. 2018 Sep;25(9):1671-1685.
C57BL6/J mice
Type 1 diabetes model
Intraperitoneal injection
50 mg/kg
Once daily for 12 weeks
To evaluate the protective effect of MAO inhibitor Pargyline on diabetic hearts. Results showed that Pargyline treatment significantly restored AKT activation in diabetic hearts and improved cardiac function.
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