There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Trans-2-Phenylcyclopropylamine (2-PCPA) is a time-dependent, mechanism-based irreversible inhibitor of LSD1 with a KI of 242 mM and a kinact of 0.0106 s-1. 2-PCPA shows limited selectivity for human MAOs versus LSD1, with kinact/KI values only 16-fold and 2.4-fold higher for MAO B and MAO A, respectively[3]. 2-PCPA-based inhibitors featuring substitutions on the amino group have emerged, with sub-micromolar affinities toward LSD1 (Lysine-specific demethylase 1) and high selectivities over monoamine oxidases (MAOs)[4]. Mice treated with the antidepressant trans-2-phenylcyclopropylamine (2-PCPA) were protected against diet-induced-obesity, and adiposity was reversed in pre-established diet-induced obese mice. 2-PCPA can reduce obesity by decreasing food intake in the long term while increasing activity in the short-term[5].
Tranylcypromine HCl 细胞实验
Cell Line
Concentration
Treated Time
Description
References
NCI-H510A
0.002 to 2000 nM
10 days
Evaluate the effect of Tranylcypromine on SCLC cell viability
ACS Pharmacol Transl Sci. 2021 Nov 12;4(6):1818-1834.
Jurkat cells
10 µM
12 hours
Evaluate the effect on LSD1-dependent transcriptional regulation, results showed S1427 significantly downregulated NOTCH3 expression
ACS Med Chem Lett. 2022 Apr 29;13(5):848-854.
MV(4;11)
0.002 to 2000 nM
24 hours
Evaluate the effect of Tranylcypromine on LSD1 target engagement
ACS Pharmacol Transl Sci. 2021 Nov 12;4(6):1818-1834.
Human prostate carcinoma (LNCaP-LN3) cells
0.5, 1, 1.5, 2 mM
24, 48, 72, 96, 120 hours
To investigate the effect of Tranylcypromine on cell proliferation, results showed increased proliferation in Tranylcypromine-treated cells
Oncol Rep. 2013 Oct;30(4):1587-92.
Human lung epithelial cells (A549)
0.5 and 1 mM
48 hours
To evaluate the antiviral effect of TCP on HSV-1 and adenovirus, results showed that TCP at 1 mM significantly reduced viral titers.
Tranylcypromine did not alter LPS-induced proinflammatory cytokine levels
Cells. 2020 Aug 28;9(9):1982.
BV2 microglial cells
5 µM
5.5 hours
Tranylcypromine significantly decreased LPS-induced IL-1β and IL-6 mRNA levels
Cells. 2020 Aug 28;9(9):1982.
THP-1
0.002 to 2000 nM
96 hours
Evaluate the effect of Tranylcypromine on CD11b marker induction
ACS Pharmacol Transl Sci. 2021 Nov 12;4(6):1818-1834.
TF-1a
0.002 to 2000 nM
96 hours
Evaluate the effect of Tranylcypromine on AML cell viability
ACS Pharmacol Transl Sci. 2021 Nov 12;4(6):1818-1834.
Tranylcypromine HCl 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6 mice
Induced endometriosis model
Intra-peritoneal injection
1 or 2 mg/kg
Every two days for two weeks
Significantly and substantially reduced the lesion size and improved generalized hyperalgesia in a dose-dependent fashion
Reprod Biol Endocrinol. 2016 Apr 9;14:17
ICR mice
Xenoplanted mouse cancer model
Intraperitoneal injection
10 mg/5 mL/kg
Single dose
Evaluate pharmacokinetic profiles, results showed S1427 had significantly better AUC0?∞, Cmax, and T1/2 compared to S2157
ACS Med Chem Lett. 2022 Apr 29;13(5):848-854.
ICR mice
HSV-1 infection model
Topical on cornea and intraperitoneal injection
10 mg/kg
Once daily for 3 days
To evaluate the in vivo antiviral effect of TCP on HSV-1 infection, results showed that TCP pretreatment significantly reduced viral titers in mouse eyes.
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