Polyphyllin VI, a natural product isolated and purified from the rhizomes of Paris yunnanensis Franch. with hemostasis, expectorant, bacteriostasis, anticytotoxic, anti-pregnancy and sperm-killing effects.
Polyphyllin VI, a natural product isolated and purified from the rhizomes of Paris yunnanensis Franch. with hemostasis, expectorant, bacteriostasis, anticytotoxic, anti-pregnancy and sperm-killing effects. Polyphyllin VI (PPVI), a main saponin isolated from TTM, significantly suppress the proliferation of non-small cell lung cancer (NSCLC) via the induction of apoptosis and autophagy in vitro and in vivo[3]. Polyphyllin VI could potently inhibit cell proliferation by causing G2/M phase arrest. Polyphyllin VI may effectively induce apoptosis and autophagy to suppress cell growth via ROS/JNK activation in U2OS (human osteosarcoma cells) cells[4]. Furthermore, JNK and p38 inhibitors ameliorated PPVI-triggered autophagy and apoptosis in glioma cells. PPVI inhibited tumor growth of U87 cell line in nude mice[5]. Polyphyllin VI changed cell morphology and induced apoptosis in HepaRG cells. Polyphyllin VI induced cell apoptosis through mitochondrial pathway by the generation of ROS and Fas death-dependent pathway. All of the effects are in dose- and time-dependent manners[6].
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