Peiminine is an alkaloid extracted from the bulb of Fritillaria thunbergii Miq that reportedly has anticancer and anti-inflammatory effects. Peiminine downregulated the levels of specific genes and proteins in vitro and consequently suppressed OC (Osteoclasts) differentiation and function[2]. Peiminine inhibits lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury, by reducing circulating IFN-γ levels and inhibiting signal transduction pathways involving TGF-β, CTGF, ERK1/2, NF-κB and FasL[3]. Peiminine induced G0/G1-phase arrest, apoptosis, and autophagy in human osteosarcoma cells via the ROS/JNK signaling pathway both in vitro and in vivo[4]. Peiminine (1, 3, or 5 mg/kg) could reduce the W/D ratio and the MPO activity significantly. Furthermore, the histopathological changes and the expression of TNF-α, IL-1β, and IL-6 were inhibited after the peiminine treatment. In vitro, peiminine significantly inhibited LPS-induced IL-8 production in A549 lung epithelial cells[5]. Peiminine suppressed the development of CRC through inhibiting the viability, colony formation and metastasis of CRC (Colorectal cancer) cells via LINC00659/miR-760 axis[6].
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