Oroxin A是Oroxylum indicum（大戟科）的种子提取物（OISE）中的主要成分，通过与PPARγ蛋白的配体结合域结合，激活过氧化物酶体增殖物激活受体γ（PPARγ）。Oroxin A 具有抑制α-葡萄糖苷酶的活性，并展现抗氧化能力。Oroxin A 通过诱导内质网应激介导的衰老效应，表现出抗乳腺癌作用。
To evaluate the protective effect of Oroxin A on neuronal damage in the SAH model. Results showed that Oroxin A significantly alleviated hemin-induced neuronal injury and inhibited ferroptosis.
J Neuroinflammation. 2024 May 3;21(1):116.
HepG2 cells
5 μM or 50 μM
24 h
Oroxin A reduced lipid accumulation in oleic acid-induced HepG2 cells, decreased cellular TG and TC levels, and inhibited the transcriptional activity of SREBP1 and SREBP2.
Heliyon. 2024 Apr 3;10(7):e29168.
HT22 cells
5 µM
48 h
To evaluate the neuroprotective effects of Oroxin A on HT22 cells in the SAH model. Results showed that Oroxin A significantly alleviated hemin-induced neuronal injury and inhibited ferroptosis.
J Neuroinflammation. 2024 May 3;21(1):116.
Oroxin A/木蝴蝶苷A 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6 mice
Subarachnoid hemorrhage (SAH) model
Tail vein injection
5 mg/kg
Single dose, observed for 48 hours
To evaluate the protective effect of Oroxin A on early brain injury after SAH. Results showed that Oroxin A significantly improved survival rates, neurological functions, mitigated neuronal death and brain edema, and attenuated the inflammatory response.
J Neuroinflammation. 2024 May 3;21(1):116.
Sprague-Dawley rats
High-fat diet-induced lipid metabolism disorder model
Oral gavage
50 mg/kg or 200 mg/kg
Once daily for 3 months
Oroxin A improved disordered lipid metabolism in high-fat diet-fed non-insulin-resistant rats, reduced plasma and hepatic lipid levels, and enhanced the lipid-lowering effect of atorvastatin.
Heliyon. 2024 Apr 3;10(7):e29168.
C57BL/6 mice
Subarachnoid hemorrhage (SAH) model
Tail vein injection
5 mg/kg
Single dose, observed for 48 hours
To evaluate the neuroprotective effects of Oroxin A in the SAH model. Results showed that Oroxin A significantly improved survival rates, enhanced neurological functions, mitigated neuronal death and brain edema, and attenuated the inflammatory response.
搜索
