There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Omeprazole sodium (H 16868 sodium), another form of this proton pump inhibitor, also targets acid-related gastrointestinal disorders and similarly inhibits CYP2C19 activity with a Ki of 2 to 6 μM[1]. This sodium salt form also restricts the growth of both Gram-positive and Gram-negative bacteria[2]. Omeprazole is a significant inhibitor of neutral sphingomyelinase (N-SMase), impacting brain pathways related to exosome production[3].
体外研究
For treating gastrointestinal disorders, Omeprazole (H 16868) has shown to significantly reduce intragastric acidity, with median 24-hour intragastric pH increasing from 1.4 to 5.3 and mean hourly hydrogen ion activity dropping from 38.50 to 1.95 mmol(mEq)/L, surpassing the effectiveness of cimetidine and ranitidine[1].
The pharmacokinetic behavior of omeprazole was evaluated in healthy male subjects who received either single or repeated doses of 30 and 60 mg. The absorption from its enteric-coated formula proved unpredictable, but a significant increase in the area under the plasma concentration-time curve (AUC) was observed after repeated doses, suggesting enhanced bioavailability, likely due to the compound's ability to inhibit its own gastric acid secretion[2].
Omeprazole sodium is a potent inhibitor of neutral sphingomyelinase (N-SMase), effectively penetrating the brain and impacting exosome regulation[3].
Omeprazole sodium/奥美拉唑钠 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Human peripheral blood mononuclear cells (PBMC)
50 μg/mL
4 and 24 hours
Evaluate the inhibitory effect of omeprazole on LPS-induced inflammatory cytokine production, results showed omeprazole inhibited TNF-α, MCP-1, IL-23, and IL-12 production
Adv Sci (Weinh). 2022 Jan;9(3):e2104051.
THP-1 cell-derived macrophages
50 μg/mL
4 hours
Evaluate the inhibitory effect of omeprazole on TLR4 signaling pathways, results showed omeprazole significantly inhibited NF-κB/AP-1 and IRF activation
Adv Sci (Weinh). 2022 Jan;9(3):e2104051.
Mouse fundic organ cultures
80 μmol/ml
12 hours
To investigate the effect of Ca2+i chelation on Shh gene expression, results showed that EGTA and BAPTA-AM significantly inhibited Shh expression.
Gastroenterology. 2010 Dec;139(6):2061-2071.e2.
Human saphenous vein segments (SV)
3 to 100 μM
24 hours
To study the effect of omeprazole on NO production, results showed that omeprazole significantly inhibited NOx release.
Circulation. 2013 Aug 20;128(8):845-53.
Human microvascular endothelial cells (HMVECs)
20 μM
24 hours
To study the effect of PPIs on ADMA concentration in endothelial cells, results showed that PPIs increased intracellular ADMA by ~30%.
Circulation. 2013 Aug 20;128(8):845-53.
RAW264.7 macrophages
50 µM
72 hours
Test the protective effect of omeprazole on Mycobacterium tuberculosis-infected macrophages, results showed omeprazole failed to protect macrophages at 50 µM
Nat Commun. 2015 Jul 9;6:7659.
MRC-5 lung fibroblasts
50 µM
72 hours
Test the protective effect of omeprazole against Mycobacterium tuberculosis-induced cytotoxicity, results showed omeprazole failed to protect fibroblasts at 50 µM
Nat Commun. 2015 Jul 9;6:7659.
Omeprazole sodium/奥美拉唑钠 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
Men1ΔIEC; Sst−/− mice
Oral
200 ppm chow
6 months to 1 year
To study the effect of omeprazole on gastrin expression and menin nuclear export in Men1ΔIEC; Sst?/? mice, results showed omeprazole treatment increased gastrin expression and menin nuclear export.
Gastroenterology. 2017 Dec;153(6):1555-1567.e15
Mice
Wild-type mice
Intraperitoneal injection
400 μmol/kg
Once daily for 3 consecutive days
To investigate the effect of omeprazole on gastric acid secretion and Shh gene expression, results showed that omeprazole significantly inhibited gastric acid secretion and Shh gene expression.
Gastroenterology. 2010 Dec;139(6):2061-2071.e2.
Mice
Wild-type C57BL/6 mice
Intraperitoneal injection
10 μmol/mouse
Single injection, euthanized after 2 hours
Omeprazole inhibited gastric acid secretion and reduced Shh expression, with additive effect when combined with IL-1β
To evaluate the effect of omeprazole on the distribution of H. pylori in the stomach. Results showed that omeprazole-mediated acid suppression promoted H. pylori colonization in the proximal and distal corpus but did not alter its distribution within the gastric glands.
Gastroenterology. 2019 Jan;156(1):160-174.e7
Mice
Men1ΔIEC; Sst−/− mouse model
Dietary administration
200 ppm
6 months
To investigate the effect of omeprazole on gastric carcinoid development. Results showed that omeprazole treatment accelerated gastric carcinoid formation in Men1ΔIEC; Sst?/? mice, associated with hypergastrinemia.
Gut. 2017 Jun;66(6):1012-1021
Mice
Gastric mucosal injury model
Intraperitoneal injection
60 mg/kg
At least 30 minutes before surgery
Omeprazole reduced maximal damage size and accelerated epithelial repair, although only at pH 3 did omeprazole further increase surface pH above the level caused by imposed damage.
Gut. 2012 Jun;61(6):804-11
Mice
Acute esophagitis model
Subcutaneous injection
400 μmol/kg
Single dose administered 1 hour before surgery
Omeprazole significantly reduced MPO activity and pathological damage scores in wild-type mice, similar to the effect of the VR-1 antagonist capsazepine.
Gut. 2006 Jan;55(1):34-40
C57BL/6 wild-type male mice
LPS-induced acute lung injury (ALI) model
Intratracheal injection
75 μg/kg Nano-OM
Single dose, samples collected after 24 hours
Evaluate the therapeutic effect of nano-omeprazole on ALI, results showed nano-omeprazole reduced inflammatory cell infiltration and cytokine production, protecting the lungs from injury
Adv Sci (Weinh). 2022 Jan;9(3):e2104051.
INS-GAS mice
H. pylori infection model
Oral
400 μmol/kg/d
Twice daily for 7 days
To evaluate the efficacy of omeprazole combined with antibiotics in preventing the progression of gastric cancer in H. pylori-infected mice. Results showed that early treatment (8 weeks) completely prevented the development of GIN, while treatments at 12 and 22 weeks also significantly reduced the severity of GIN.
Cancer Res. 2008 May 1;68(9):3540-8
Male C57BL/6JJcl mice
High-fructose diet-induced small intestine injury model
Intraperitoneal injection
20 mg/kg
Once daily for 9 weeks
Omeprazole exacerbated ASA-induced intestinal damage, significantly decreased Bifidobacteria levels, and significantly increased A. muciniphila counts in the jejunum.
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