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/ Minoxidil/敏乐啶

Minoxidil/敏乐啶 {[allProObj[0].p_purity_real_show]}

货号：A141385 同义名： 米诺地尔 / U10858; Loniten

Minoxidil是一种是 ATP 敏感的钾通道 (KATP) 开放剂，是有效的口服降压药，可促进血管扩张，减缓或停止脱发，并促进头发再生。Minoxidil 还是一种大豆脂氧合酶的有效抑制剂，其 IC50 值为 20 μM。

Minoxidil/敏乐啶 化学结构 CAS号：38304-91-5
Minoxidil/敏乐啶 化学结构
CAS号：38304-91-5
Minoxidil/敏乐啶 3D分子结构
CAS号：38304-91-5
Minoxidil/敏乐啶 化学结构 CAS号：38304-91-5
Minoxidil/敏乐啶 3D分子结构 CAS号：38304-91-5
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Minoxidil/敏乐啶 纯度/质量文件 产品仅供科研

货号：A141385 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

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产品名称 Potassium Channel ↓ 其他靶点 纯度
Tolbutamide ✔ 98%
Glimepiride ++++

SUR2B, IC50: 7.3 nM

SUR1, IC50: 5.4 nM

 		97%
Dronedarone HCl ✔ 95%
Gliquidone ++

Potassium channel, IC50: 27.2 nM

 		99%
TRAM-34 +++

IKCa1 (KCa3.1), Kd: 20 nM

 		98%
Glibenclamide ✔ 98%
Amiodarone HCl ✔ 97%
Gliclazide ++

Potassium channel, IC50: 184 nM

 		98%
Repaglinide ✔ 98%
Dofetilide ✔ 98%
Nateglinide ✔ 99%
Quinine HCl dihydrate ✔ 98%
ML133 HCl +

Kir2.1, IC50: 290 nM

 		99%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Minoxidil/敏乐啶 生物活性

描述 Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM. Minoxidil (0.01 mmoL/kg body weight; intraperitoneal injection; for 3.5 hours; fisher 344 rats) treatment inhibits carrageenan-induced rat paw oedema with an inhibitory potency (49%)[3]. Minoxidil induces generalized hypertrichosis when administered systemically, or localized hair regrowth when applied topically to sites of severe alopecia areata. In the presence of minoxidil, cultures showed a marked dose-dependent second peak of DNA synthesis 8-10 days after culture initiation in epidermal cells. In addition, two morphologically distinct cell types appeared[4]. Minoxidil is a potassium channel opener, causing hyperpolarization of cell membranes and it is also a vasodilator, by widening blood vessels and opening potassium channels, it allows more oxygen, blood and nutrients to the follicle. This can also cause follicles in the telogen phase to shed, usually soon to be replaced by new, thicker hairs in a new anagen phase. The most common adverse reactions of the topical formulation are limited to irritant and allergic contact dermatitis on the scalp[5].

Minoxidil/敏乐啶 细胞实验

Cell Line
Concentration Treated Time Description References
Human dermal papilla cells (HDPCs) 0.0002 48 hours Evaluate the effect of HL@Mi/NONOate on the proliferation of HDPCs. Results showed that the cell proliferation rate in the HL@Mi/NONOate group was 161.90%, significantly higher than the HL@Mi group (103.63%) and the control group. Bioact Mater. 2023 Oct 11;32:190-205
Human Umbilical Vein Endothelial Cells (HUVECs) 0.0002 48 hours Evaluate the effect of HL@Mi/NONOate on the proliferation of HUVECs. Results showed that the cell proliferation rate in the HL@Mi/NONOate group was 153.77%, significantly higher than the HL@Mi group (115.18%) and the control group. Bioact Mater. 2023 Oct 11;32:190-205
human dermal papilla cells (DPCs) 0.5, 1, 2 mM 4 hours To investigate the induction of HIF-1α protein by minoxidil, results showed that 2 mM minoxidil significantly induced HIF-1α protein expression. Int J Mol Sci. 2017 Dec 25;19(1):53
human keratinocytes (HaCaT cells) 0.5, 1, 2 mM 4 hours To investigate the induction of HIF-1α protein by minoxidil, results showed that 2 mM minoxidil significantly induced HIF-1α protein expression. Int J Mol Sci. 2017 Dec 25;19(1):53
Adipose-derived stem cells (ASCs) 20 and 50 µM 2 days and 7 days Minoxidil did not alter ASC proliferation but increased migration and tube formation Int J Mol Sci. 2018 Feb 28;19(3):691
Caco-2 cells 80 µg/mL (382 µM) 120 minutes Evaluate the permeability of minoxidil across Caco-2 cell monolayers, showing that tight junction modifiers (quercetin and sodium decanoate) significantly affect its permeability. Pharmaceutics. 2022 Jun 27;14(7):1360

Minoxidil/敏乐啶 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
C57BL/6 mice Androgenetic alopecia (AGA) model Topical application 5% Minoxidil Once daily for 28 days Compare the hair regeneration effects of V-R-MN and Minoxidil in AGA model mice, with the V-R-MN group showing faster hair regeneration onset and improved hair quality. Bioact Mater. 2024 Apr 23;38:95-108
Wistar rats Single-pass intestinal perfusion model Intestinal perfusion 80 µg/mL (382 µM) 1 hour perfusion followed by an additional 1 hour of perfusion, sampling every 10 minutes Evaluate the permeability of minoxidil in different intestinal segments, showing that tight junction modifiers significantly affect its permeability. Pharmaceutics. 2022 Jun 27;14(7):1360
Rat Skin permeation model Topical application 300 μg Single dose, observed for 24 hours Evaluate the skin permeation efficiency of HA-PLGA/MXD NPs, showing higher permeation efficiency of HA-PLGA NPs compared to PLGA NPs Biomater Res. 2019 Oct 31;23:16
ICR mice Topical application 5% Single application, lasting 4 hours To investigate the effect of minoxidil on VEGF and HIF-1α levels in the skin, results showed that minoxidil significantly elevated VEGF and HIF-1α levels in mouse skins. Int J Mol Sci. 2017 Dec 25;19(1):53

Minoxidil/敏乐啶 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00283686 Kidney, Polycystic Phase 3 Completed - United States, Colorado ... 展开 >> University of Colorado Health Sciences Center Denver (Aurora), Colorado, United States, 800045 United States, Georgia Emory University School of Medicine Atlanta, Georgia, United States, 30322 United States, Kansas University of Kansas Medical Center Kansas City, Kansas, United States, 66160 United States, Massachusetts Tufts University-New England Medical Center Boston, Massachusetts, United States, 02111 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Ohio Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 收起 <<
NCT00283686 - Completed - -
NCT01227031 - Unknown July 2011 Taiwan ... 展开 >> Taipei Medical University-Wan Fang Hospital Not yet recruiting Taipei, Taiwan Contact: Ren-Yu Tsai    886-2-29307930 ext 2980    b671022@tmu.edu.tw 收起 <<

Minoxidil/敏乐啶 参考文献

[1]Grice JE, Ciotti S, et al. Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro. J Pharm Sci. 2010 Feb;99(2):712-8.

[2]Grice JE, Ciotti S, et al. Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro. J Pharm Sci. 2010 Feb;99(2):712-8.

[3]Hadjipavlou-Litina D, Magoulas GE, Bariamis SE, et al. Synthesis and evaluation of the antioxidative potential of minoxidil-polyamine conjugates. Biochimie. 2013;95(7):1437-1449

[4]Cohen RL, Alves ME, Weiss VC, West DP, Chambers DA. Direct effects of minoxidil on epidermal cells in culture. J Invest Dermatol. 1984;82(1):90-93

[5]Rossi A, Cantisani C, Melis L, Iorio A, Scali E, Calvieri S. Minoxidil use in dermatology, side effects and recent patents. Recent Pat Inflamm Allergy Drug Discov. 2012;6(2):130-136

Minoxidil/敏乐啶 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.78mL

0.96mL

0.48mL

23.89mL

4.78mL

2.39mL

47.79mL

9.56mL

4.78mL

Minoxidil/敏乐啶 技术信息

CAS号38304-91-5
分子式C9H15N5O
分子量 209.25
SMILES Code NC1=NC(N2CCCCC2)=CC(N)=[N+]1[O-]
MDL No. MFCD00063409
别名 米诺地尔 ;U10858; Loniten; Minoxidil, Loniten, Rogaine, U 10858
运输蓝冰
InChI Key ZIMGGGWCDYVHOY-UHFFFAOYSA-N
Pubchem ID 4201
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, inert atmosphere, room temperature
溶解方案

DMSO: 10 mg/mL(47.79 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 1 mg/mL(4.78 mM)，配合低频超声，并水浴加热至45℃助溶

无水乙醇: 7 mg/mL(33.45 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三
方案 四
方案 五
方案 六
配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案 一
方案 二

Tags: Minoxidil | U10858;Loniten;Minoxidil, Loniten, Rogaine, U 10858 | 米诺地尔 | Depressurization | Other Compounds | Potassium Channel | AmBeed-信号通路专用抑制剂 | Minoxidil/敏乐啶 纯度/质量文件 | Minoxidil/敏乐啶 亚型比较 | Minoxidil/敏乐啶 生物活性 | Minoxidil/敏乐啶 临床数据 | Minoxidil/敏乐啶 参考文献 | Minoxidil/敏乐啶 实验方案 | Minoxidil/敏乐啶 技术信息

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