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/ Lanatoside C/毛花甙丙

Lanatoside C/毛花甙丙 {[allProObj[0].p_purity_real_show]}

货号：A147174 同义名： 毛花苷C

Lanatoside C 是一种心脏苷类化合物，可用于研究心力衰竭及心律失常，同时在 HuH-7 细胞中对登革病毒感染的 IC50 为 0.19 μM。

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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Lanatoside C/毛花甙丙 化学结构 CAS号：17575-22-3
Lanatoside C/毛花甙丙 化学结构
CAS号：17575-22-3
Lanatoside C/毛花甙丙 3D分子结构
CAS号：17575-22-3
Lanatoside C/毛花甙丙 化学结构 CAS号：17575-22-3
Lanatoside C/毛花甙丙 3D分子结构 CAS号：17575-22-3
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Lanatoside C/毛花甙丙 纯度/质量文件 产品仅供科研

货号：A147174 标准纯度： {[allProObj[0].p_purity_real_show]}
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产品名称 Autophagy ↓ 其他靶点 纯度
SBI-0206965 +++

ULK2, IC50: 711 nM

ULK1, IC50: 108 nM

 		95%
Hydroxychloroquine sulfate ✔ 99%
Valproic acid sodium ✔ HDAC 97%
PFK-015 ++

PFKFB3, IC50: 207 nM

 		99%+
MRT68921 HCl ++++

ULK2, IC50: 1.1 nM

ULK1, IC50: 2.9 nM

 		99%+
ROC-325 ✔ 99%+
Autophinib +++

Autophagy, IC50: 40 nM

 		99%
Lys05 ✔ 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Lanatoside C/毛花甙丙 生物活性

描述 Lanatoside C, a cardiac glycoside, is utilized in the management of congestive heart failure and cardiac arrhythmias. It demonstrates an IC50 of 0.19 μM against dengue virus in HuH-7 cells and is capable of inhibiting all four serotypes of dengue virus, as well as flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus, and human enterovirus 71[1].[2].
体外研究

Lanatoside C shows a dose-dependent reduction in both dengue viral RNA and protein synthesis with increased concentrations. Studies on the timing of addition reveal that Lanatoside C blocks the early stages of the dengue virus replication cycle. Additionally, it effectively inhibits all four dengue virus serotypes, flavivirus Kunjin, alphavirus Chikungunya, and Sindbis virus, along with human enterovirus 71, displaying a broad-spectrum antiviral activity against various positive-sense RNA viruses[2].

Lanatoside C/毛花甙丙 细胞实验

Cell Line
Concentration Treated Time Description References
Jurkat cells 2 μM 6 hours Lanatoside C significantly downregulated RUNX1 protein level EMBO Mol Med. 2025 Mar;17(3):563-588
Gli36 cells 0.25 μM 48 hours Lanatoside C enhances Gli36 cell sensitivity to TRAIL. Neuro Oncol. 2011 Nov;13(11):1213-24
HF19 primary human fibroblasts 0.25 μM 48 hours Lanatoside C shows no significant toxicity to normal fibroblasts. Neuro Oncol. 2011 Nov;13(11):1213-24
Primary GBM cells 0.25 μM 48 hours Lanatoside C significantly reduces the viability of primary GBM cells and enhances sensitivity to TRAIL. Neuro Oncol. 2011 Nov;13(11):1213-24
U87 cells 0.25 μM and 1 μM 16 hours Lanatoside C upregulates DR5 expression, enhancing GBM cell sensitivity to TRAIL-induced cell death. Neuro Oncol. 2011 Nov;13(11):1213-24
human brain endothelial cells 10 µM 24 hours Lanatoside C blocked IL-1β-induced inflammatory secretions including CCL2, sICAM-1, sVCAM-1, IL-6, IL-8, CX3CL1, RANTES, G-CSF, and GM-CSF Commun Biol. 2021 Feb 26;4(1):260
EL4 cells 2 μM 6 hours Lanatoside C significantly downregulated RUNX1 protein level EMBO Mol Med. 2025 Mar;17(3):563-588
MCF-7 1 μM or 5 μM 24 hours LanC suppressed the increase in GRP78 expression induced by Tg Neoplasia. 2021 Dec;23(12):1213-1226
SK-MEL-28 1 μM or 5 μM 24 hours LanC suppressed the increase in GRP78 expression induced by Tg Neoplasia. 2021 Dec;23(12):1213-1226
HeLa 1 μM or 5 μM 24 hours LanC suppressed the increase in GRP78 expression induced by Tg Neoplasia. 2021 Dec;23(12):1213-1226
SCC-25 1 μM or 5 μM 24 hours LanC suppressed the increase in GRP78 expression induced by Tg Neoplasia. 2021 Dec;23(12):1213-1226
A549 1 μM or 5 μM 24 hours LanC suppressed the increase in GRP78 expression induced by Tg Neoplasia. 2021 Dec;23(12):1213-1226
CFPAC-1 1 μM 24 hours LanC suppressed the increase in GRP78 expression induced by Tg, Tu, or 2-DG Neoplasia. 2021 Dec;23(12):1213-1226
PANC-1 1 μM 24 hours LanC suppressed the increase in GRP78 expression induced by Tg, Tu, or 2-DG, bringing its level close to that of untreated cells Neoplasia. 2021 Dec;23(12):1213-1226
GBM8 neural sphere cells 0.25 μM 24 hours To evaluate the effect of Lanatoside C combined with sTRAIL on the viability of GBM8 neural sphere cells. Results showed that GBM8 neural sphere cells were more sensitive to sTRAIL and Lanatoside C alone, and the combination treatment resulted in a significant decrease in cell viability (around 90%). Mol Oncol. 2016 Apr;10(4):625-34
U87 human glioblastoma cells 0.25 μM 24 hours To evaluate the effect of Lanatoside C combined with sTRAIL on the viability of U87 cells. Results showed that sTRAIL alone did not cause cell death, while 0.25 μM Lanatoside C alone caused approximately 50% cell death. The combination of sTRAIL and Lanatoside C resulted in a significant decrease in cell viability (around 80%). Mol Oncol. 2016 Apr;10(4):625-34
293T-NF+RC cells 10 μM 30 minutes Lanatoside C potently inhibited the interaction between FOXP3 and RUNX1 EMBO Mol Med. 2025 Mar;17(3):563-588
human brain pericytes 10 µM 24 hours Screening for compounds that modulate IL-1β-induced CCL2 and ICAM-1 expression, Lanatoside C showed anti-inflammatory effects Commun Biol. 2021 Feb 26;4(1):260

Lanatoside C/毛花甙丙 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Nude mice U87-Gluc-CFP subcutaneous xenograft model Intraperitoneal injection 6 mg/kg body weight Once daily for 10 days Lanatoside C alone or in combination with TRAIL significantly inhibits tumor growth, with combination therapy reducing tumor volume by more than 85%. Neuro Oncol. 2011 Nov;13(11):1213-24
BALB/c nude mice DLBCL xenograft model Intraperitoneal injection 6 mg/kg Every two days until the end of the experiment To evaluate the inhibitory effect of Lanatoside C on DLBCL tumor growth Leukemia. 2024 Feb;38(2):351-364
Athymic nude mice Intracranial U87 glioblastoma model Intraperitoneal injection 7.5 mg/kg Once daily for 5 days To evaluate the effect of Lanatoside C combined with AAV-sTRAIL on intracranial U87 tumors. Results showed that Lanatoside C treatment led to a significant decrease in tumor-associated Fluc signal, and tumors regrew rapidly after stopping treatment. Re-administration of Lanatoside C re-sensitized tumors to sTRAIL-induced cell death. The combination therapy significantly slowed tumor growth and prolonged mouse survival. Mol Oncol. 2016 Apr;10(4):625-34
C57BL/6J mice LLC allograft tumor model Intraperitoneal injection (IP) 6 mg/kg Every 2 days for 2 weeks Lanatoside C significantly inhibited the growth of LLC tumors EMBO Mol Med. 2025 Mar;17(3):563-588

Lanatoside C/毛花甙丙 参考文献

[1]Crommentuijn MH, et al. Intracranial AAV-sTRAIL combined with lanatoside C prolongs survival in an orthotopic xenograft mouse model of invasive glioblastoma. Mol Oncol. 2015 Dec 11. pii: S1574-7891(15)00226-4.

[2]Cheung YY, et al. Antiviral activity of lanatoside C against dengue virus infection. Antiviral Res. 2014 Nov;111:93-99.

Lanatoside C/毛花甙丙 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.02mL

0.20mL

0.10mL

5.08mL

1.02mL

0.51mL

10.15mL

2.03mL

1.02mL

Lanatoside C/毛花甙丙 技术信息

CAS号17575-22-3
分子式C49H76O20
分子量 985.12
SMILES Code O[C@]([C@@](CC[C@@]1([H])[C@@]2(CC[C@H](O[C@@](O[C@H](C)[C@H]3O[C@@](O[C@H](C)[C@H]4O[C@@](O[C@H](C)[C@H]5O[C@]([C@@H]([C@@H](O)[C@@H]6O)O)([H])O[C@@H]6CO)([H])C[C@@H]5OC(C)=O)([H])C[C@@H]4O)([H])C[C@@H]3O)C1)C)([H])[C@]2([H])C[C@H]7O)(CC[C@@H]8C(CO9)=CC9=O)[C@]78C
MDL No. MFCD00869432
别名 毛花苷C
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, store in freezer, under -20°C
溶解方案

DMSO: 50 mg/mL(50.76 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 2 mg/mL(2.03 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三
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方案 五
方案 六

Tags: Lanatoside C | 17575-22-3 | Dengue virus | Flavivirus | Autophagy | Anti-infection | Dengue virus | Flavivirus | Autophagy | Enterovirus | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Lanatoside C/毛花甙丙 纯度/质量文件 | Lanatoside C/毛花甙丙 亚型比较 | Lanatoside C/毛花甙丙 生物活性 | Lanatoside C/毛花甙丙 参考文献 | Lanatoside C/毛花甙丙 实验方案 | Lanatoside C/毛花甙丙 技术信息

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