There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
LY2183240 is a highly potent blocker of anandamide uptake (IC50 = 270 pM).
LY2183240 细胞实验
Cell Line
Concentration
Treated Time
Description
References
HeLa cells
10 μM
20–40 hours
Measure inhibition of [14C]-anandamide uptake
Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):407-23
mouse primary cortical neurons
10 μM
24 and 72 hours
To investigate the effect of LY-2183240 on cell death and morphology, results showed that LY-2183240 induces neuronal death with an IC50 of 6.9 μM and significantly reduced the total DAPI number, DAPI + NeuN number, and MAP2 intensity.
iScience. 2024 Sep 30;27(11):111069
rat primary cortical neurons
10 μM
To ascertain whether the rise in APs induced by LY-2183240 is linked to an elevation in intracellular Ca2+ level, results showed no discernible calcium response by LY-2183240.
iScience. 2024 Sep 30;27(11):111069
mouse cortical neurons
10 μM
To evaluate the effect of LY-2183240 on the intrinsic excitability of neurons, results showed that LY-2183240 increased the number of spontaneous action potentials (sAPs) and elevated the resting membrane potential (RMP).
iScience. 2024 Sep 30;27(11):111069
chick embryo spinal motoneurons
1 μM
20-40 minutes
LY2183240 significantly reduced AMPA miniature postsynaptic current frequency without affecting amplitude.
J Neurosci. 2012 Sep 26;32(39):13597-607
RBL-2H3 cells
10 μM
16–20 hours
Measure inhibition of [14C]-anandamide uptake
Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):407-23
LY2183240 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
Formalin-induced inflammatory pain model
Intraperitoneal injection
2.5-5 mg/kg
Single dose, 15 min before formalin injection
LY2183240 significantly inhibited the second phase of formalin-induced nocifensive response, which was fully antagonized by CB1 receptor antagonists
Br J Pharmacol. 2008 Nov;155(5):775-82
Mice
High alcohol-preferring (HAP) and low alcohol-preferring (LAP) mice
Intraperitoneal injection
10 and 30 mg/kg
Administered 30 min prior to testing, lasting 48 hours
To assess the effects of LY2183240 on fear-potentiated startle (FPS) and alcohol-seeking behaviors in high alcohol-preferring (HAP) and low alcohol-preferring (LAP) mice. Results showed that LY2183240 (30 mg/kg) reduced the expression of FPS in HAP mice during the second FPS test but had no effect in LAP mice. Additionally, LY2183240 enhanced alcohol-induced conditioned place preference (CPP) but did not significantly alter limited-access alcohol drinking behavior.
Psychopharmacology (Berl). 2010 Dec;212(4):571-83
C57BL/6 mice
Conditioned place preference (CPP) and self-administration (SA) models
CPP: every other day for 4 times; SA: once daily for 12 days
To evaluate the effect of LY-2183240 on reward-seeking behavior, results showed that LY-2183240 increased the lever pressing in SA tests and altered dwelling times in CPP tests, indicating its potential for abuse.
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