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Biochanin A/鹰嘴豆芽素A
Biochanin A/鹰嘴豆芽素A
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货号：A120547
同义名：
4-Methylgenistein; Olmelin
Biochanin A 是一种天然异黄酮，是脂肪酸酰胺水解酶 (FAAH) 抑制剂，具有抗氧化、抗炎和抗癌作用。Biochanin A 主要用于癌症预防和治疗的研究。
Biochanin A/鹰嘴豆芽素A 化学结构
Biochanin A/鹰嘴豆芽素A 3D分子结构
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Biochanin A/鹰嘴豆芽素A 纯度/质量文件 产品仅供科研
货号：A120547
标准纯度：
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Biochanin A/鹰嘴豆芽素A 质控信息
URB-597
++++
99%
JNJ-1661010
+++
FAAH (human), IC50: 12 nM
FAAH (rat), IC50: 10 nM
99%
Biochanin A
+
FAAH (human), IC50: 1.4 μM
FAAH (mouse), IC50: 1.8 μM
EGFR
98+%
PF-3845
++
99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Biochanin A/鹰嘴豆芽素A 生物活性
靶点
FAAH
FAAH (human), IC50:1.4 μM
FAAH (mouse), IC50:1.8 μM
描述
Anandamide (arachidonoylethanolamide, AEA) is endogenous ligands of cannabinoid CB1 and CB2 receptors and AEA is metabolized by the enzyme fatty acid amide hydrolase (FAAH). Biochanin A (4-Methylgenistein; Olmelin), a major isoflavone in red clover, is a naturally occurring FAAH inhibitor, with IC50 values of 1.8, 1.4 and 2.4 µM for mouse, rat and human FAAH ,respectively[3] In vitro , Biochanin A inhibited human osteosarcoma cell growth and colony formation in a dose-dependent manner, and induced apoptosis by triggering activation of the intrinsic mitochondrial pathway and caspase-9 and -3[4] In vivo , type 2 diabetes mellitus animals treated with 10, 20 and 40 mg/kg of Biochanin A for 28 days showed significantly decreased blood glucose, reduced insulin resistance and improved inulin sensitivity, compared to model group. These effects might be linked to its effects on SIRT1[5]
Biochanin A/鹰嘴豆芽素A 临床研究
NCT号
适应症或疾病
临床期
招募状态
预计完成时间
地点
NCT02174666
Osteopenia
Os... 展开 >> teoporosis 收起 <<
Not Applicable
Unknown
September 2016
Denmark
... 展开 >> Aarhus University Hospital
Aarhus, Central Jutland Region, Denmark, 8000 收起 <<
Biochanin A/鹰嘴豆芽素A 参考文献
[1] Thors L, Burston JJ, et al. Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase. Br J Pharmacol. 2010 Jun;160(3):549-60.
[2] Akiyama T, Ishida J, et al. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem. 1987 Apr 25;262(12):5592-5.
[3] Thors L, Burston JJ, Alter BJ, McKinney MK, Cravatt BF, Ross RA, Pertwee RG, Gereau RW 4th, Wiley JL, Fowler CJ. Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase. Br J Pharmacol. 2010 Jun;160(3):549-60. doi: 10.1111/j.1476-5381.2010.00716.x. PMID: 20590565; PMCID: PMC2931556.
[4] Hsu YN, Shyu HW, Hu TW, Yeh JP, Lin YW, Lee LY, Yeh YT, Dai HY, Perng DS, Su SH, Huang YH, Su SJ. Anti-proliferative activity of biochanin A in human osteosarcoma cells via mitochondrial-involved apoptosis. Food Chem Toxicol. 2018 Feb;112:194-204. doi: 10.1016/j.fct.2017.12.062. Epub 2018 Jan 3. PMID: 29305928.
[5] Oza MJ, Kulkarni YA. Biochanin A improves insulin sensitivity and controls hyperglycemia in type 2 diabetes. Biomed Pharmacother. 2018 Nov;107:1119-1127. doi: 10.1016/j.biopha.2018.08.073. Epub 2018 Aug 27. PMID: 30257324.
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Biochanin A/鹰嘴豆芽素A 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
3.52mL
0.70mL
0.35mL
17.59mL
3.52mL
1.76mL
35.18mL
7.04mL
3.52mL
Biochanin A/鹰嘴豆芽素A 技术信息
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