To investigate the effect of SERCA2a overexpression and STAT3 inhibitor HJC0152 on BMPR2 expression in hPAECs, results showed that STAT3i potentiated SERCA2a-induced BMPR2 expression.
Int J Mol Sci. 2021 Aug 24;22(17):9105
Human pulmonary artery smooth muscle cells (hPASMCs)
1 μM
48 hours
To evaluate the effect of STAT3 inhibitor HJC0152 on BMPR2 expression in hPASMCs, results showed that SERCA2a overexpression upregulated BMPR2 expression by inhibiting STAT3 activity.
Int J Mol Sci. 2021 Aug 24;22(17):9105
HGC-27 cells
0, 5, 10, 20 µM
0, 24, 48, 72 hours
To evaluate the effect of HJC0152 on cell growth, results showed that HJC0152 only inhibited the growth of HGC-27 cells at relatively high concentrations
Cancer Manag Res. 2018 Dec 12;10:6857-6867
MKN45 cells
0, 5, 10, 20 µM
0, 24, 48, 72 hours
To evaluate the effect of HJC0152 on cell growth, results showed that HJC0152 significantly inhibited the growth of MKN45 cells
Cancer Manag Res. 2018 Dec 12;10:6857-6867
AGS cells
0, 5, 10, 20 µM
0, 24, 48, 72 hours
To evaluate the effect of HJC0152 on cell growth, results showed that HJC0152 significantly inhibited the growth of AGS cells
Cancer Manag Res. 2018 Dec 12;10:6857-6867
HJC0152 free base 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
BALB/c nude mice
A549 NSCLC xenograft model
Oral
7.5 mg/kg
Once daily for 30 days
HJC0152 significantly inhibited the growth of A549 xenograft tumours, extending the tumour volume doubling time from 2.03 days to 4.62 days.
Cell Prolif. 2020 Mar;53(3):e12777
BALB/c-nu mice
SCC25-derived orthotopic tongue tumor model
Intraperitoneal injection
7.5 mg/kg
Daily administration for 28 days
Significantly inhibited tumor growth and invasion
Mol Cancer Ther. 2017 Apr;16(4):578-590
C57BL/6 mice
CVB3-induced acute pancreatitis and myocarditis model
Intraperitoneal injection
12.5 mg/kg
Once 24 hours before and once 24 hours after infection
Alleviates viral-induced pancreatitis and myocarditis pathology by increasing IFNβ and ISG expression to reduce viral load
Int J Mol Sci. 2024 Aug 19;25(16):9007
Rats
Severe PAH model induced by unilateral left pneumonectomy combined with monocrotaline (PNT/MCT)
Intraperitoneal injection
7.5 mg/kg
Single injection, lasting 4 weeks
To evaluate the therapeutic effect of STAT3 inhibitor HJC0152 combined with AAV1.hSERCA2a in the PAH model, results showed that combination therapy significantly reduced pulmonary artery pressure and vascular remodeling, and improved right ventricular function.
Int J Mol Sci. 2021 Aug 24;22(17):9105
Nude mice
MDA-MB-231 xenograft model
Intraperitoneal injection and oral
7.5 mg/kg (ip), 25 mg/kg (po)
Evaluate the inhibitory effect of HJC0152 on the growth of MDA-MB-231 xenograft tumors
Am J Cancer Res. 2019 Apr 1;9(4):699-713
Nude mice
MDA-MB-231 xenograft model
Intraperitoneal injection and oral
7.5 mg/kg (ip), 25 mg/kg (po)
Evaluate the inhibitory effect of HJC0152 on the growth of MDA-MB-231 xenograft tumors
ACS Med Chem Lett. 2013 Feb 14;4(2):180-185
BALB/c nude mice
MKN45 subcutaneous xenograft model
Intraperitoneal injection
7.5 mg/kg
Twice weekly for 21 days
To evaluate the anti-tumor effect of HJC0152 in vivo, results showed that HJC0152 significantly inhibited tumor growth
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