FIIN-2 | FGFR Inhibitor | AmBeed-信号通路专用抑制剂

FIIN-2 {[allProObj[0].p_purity_real_show]}

货号：A483586

FIIN-2是一种不可逆的FGFR1-4抑制剂，其IC50值分别为3.1、4.3、27和45 nM。

FIIN-2 化学结构
CAS号：1633044-56-0

FIIN-2 3D分子结构
CAS号：1633044-56-0

规格	价格	会员价	库存	数量
{[ item.pr_size ]}	{[ getRatePriceInt(item.pr_rmb, 1,1) ]} {[ getRatePriceInt(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}	{[ getRatePriceInt(item.pr_rmb, 1,1) ]} {[ getRatePriceInt(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}	{[ getRatePriceInt(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}	{[ getRatePrice(item.pr_rmb_sale, 1,1,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate,item.mem_isinteger) ]}	现货	1周咨询	- +

购物车0 收藏询单

sales@ambeed.cn tech@ambeed.cn 400-920-2911 产品手册产品订购技术咨询
快速发货顺丰冷链运输，1-2 天到达

品质保证

技术支持

免费溶解

FGFR 亚型比较

产品名称	FGFR ↓ ↑	FGFR1 ↓ ↑	FGFR2 ↓ ↑	FGFR3 ↓ ↑	FGFR4 ↓ ↑	其他靶点	纯度
Tyrphostin AG1296	+ FGFR (Swiss 3T3), IC50: 12.3 μM					PDGFR	99%+
Pazopanib	+ FGFR, IC50: 140 nM						99%
Erdafitinib	✔					RET	99%+
Gambogenic acid	✔						98+%
Sulfatinib		+++ FGFR1, IC50: 15 nM					99+%
Nintedanib esylate		+ FGFR1, IC50: 69 nM	++ FGFR2, IC50: 37 nM	+ FGFR3, IC50: 108 nM			98%
Zoligratinib		+++ FGFR1, IC50: 9.3 nM	+++ FGFR2, IC50: 7.6 nM	++ FGFR3, IC50: 22 nM	+ FGFR4, IC50: 290 nM		99%+
MK-2461		+ FGFR1, IC50: 65 nM	++ FGFR2, IC50: 39 nM	++ FGFR3, IC50: 50 nM			98%+
SU 5402		++ FGFR1, IC50: 30 nM					98%
Brivanib		+ FGFR1, IC50: 148 nM					99%+
Lucitanib		++ FGFR1, IC50: 17.5 nM	+ FGFR2, IC50: 82.5 nM				99%+
Ponatinib		++++ FGFR1, IC50: 2.2 nM					98%
PD-166866		+ FGFR1, IC50: 52.4 nM					99%
Narazaciclib		++ FGFR1, IC50: 26 nM				RET	99%+
Lactate		+++ FGFR1, IC50: 8 nM		+++ FGFR3, IC50: 9 nM		c-Kit,FLT3	85%
Lenvatinib mesylate		++ FGFR1, IC50: 46 nM				c-RET	99%
LY2874455		++++ FGFR1, IC50: 2.8 nM	++++ FGFR2, IC50: 2.6 nM	+++ FGFR3, IC50: 6.4 nM	+++ FGFR4, IC50: 6 nM		99%+
FIIN-2		+++ FGFR1, IC50: 3.09 nM	+++ FGFR2, IC50: 4.3 nM	++ FGFR3, IC50: 27 nM	++ FGFR4, IC50: 45.3 nM		99%
FIIN-3		+++ FGFR1, IC50: 13.1 nM	++ FGFR2, IC50: 21 nM	++ FGFR3, IC50: 31.4 nM	++ FGFR4, IC50: 35.3 nM		98%
Infigratinib		++++ FGFR1, IC50: 0.9 nM	++++ FGFR2, IC50: 1.4 nM	++++ FGFR3 (K650E), IC50: 4.9 nM FGFR3, IC50: 1.0 nM	+ FGFR4, IC50: 60 nM		99%+
Danusertib		++ FGFR1, IC50: 47 nM				RET	99%+
R1530		++ FGFR1, IC50: 28 nM					98%
ENMD-2076		+ FGFR1, IC50: 92.7 nM	+ FGFR2, IC50: 70.8 nM			RET,FLT3	98%
Dovitinib		+++ FGFR1, IC50: 8 nM		+++ FGFR3, IC50: 9 nM		c-Kit,FLT3	99%+
Sorafenib		+ FGFR1, IC50: 580 nM					99%
SSR128129E		+ FGFR1, IC50: 1.9 μM					99%+
AZD-4547		++++ FGFR1, IC50: 0.2 nM	++++ FGFR2, IC50: 2.5 nM	++++ FGFR3, IC50: 1.8 nM			98%
Lenvatinib		++ FGFR1, IC50: 46 nM				RET	98%
PD173074		++ FGFR1, IC50: ~25 nM					99%+
S49076		++ FGFR1, IC50: 18 nM	+++ FGFR2, IC50: 17 nM	+++ FGFR3, IC50: 15 nM			98%
Futibatinib		++++ FGFR1, IC50: 1.8 nM	++++ FGFR2, IC50: 1.4 nM	++++ FGFR3, IC50: 1.6 nM	+++ FGFR4, IC50: 3.7 nM		99%+
Ferulic Acid		+ FGFR1, IC50: 3.78 μM	+ FGFR2, IC50: 12.5 μM				98%
Nintedanib		+ FGFR1, IC50: 69 nM	++ FGFR2, IC50: 37 nM	+ FGFR3, IC50: 108 nM	+ FGFR4, IC50: 610 nM		99+%
ASP5878		++++ FGFR1, IC50: 0.47 nM	++++ FGFR2, IC50: 0.6 nM	++++ FGFR3, IC50: 0.74 nM	+++ FGFR4, IC50: 3.5 nM		99%
PRN1371		++++ FGFR1, IC50: 0.6 nM	++++ FGFR2, IC50: 1.3 nM	+++ FGFR3, IC50: 4.1 nM	++ FGFR4, IC50: 19.3 nM		99%
Derazantinib		+++ FGFR1, IC50: 4.5 nM	++++ FGFR2, IC50: 1.8 nM	+++ FGFR3, IC50: 4.5 nM	++ FGFR4, IC50: 34 nM	RET	99%+
ODM-203		+++ FGFR1, IC50: 11 nM	+++ FGFR2, IC50: 16 nM	+++ FGFR3, IC50: 6 nM	++ FGFR4, IC50: 35 nM		99%+
Pemigatinib		++++ FGFR1, IC50: 0.4 nM	++++ FGFR2, IC50: 0.5 nM	++++ FGFR3, IC50: 1.2 nM	++ FGFR4, IC50: 30 nM		99%+
SKLB 610			✔			PDGFR	99%+
Alofanib			✔				99%+
Lirafugratinib			✔				99%
Masitinib mesylate				✔		FAK	99%+
BLU9931				+ FGFR3, IC50: 150 nM	+++ FGFR4, IC50: 3 nM		99%+
BO-264				✔			99%+
Fisogatinib					+++ FGFR4, IC50: 5 nM		99%+
H3B-6527					++++ FGFR4, IC50: <1.2 nM		99%+
Roblitinib					++++ FGFR4, IC50: 1.9 nM		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

FIIN-2 生物活性

靶点

FGFR2

FGFR2, IC50:4.3 nM
FGFR3

FGFR3, IC50:27 nM
FGFR4

FGFR4, IC50:45.3 nM
FGFR1

FGFR1, IC50:3.09 nM

描述

FIIN-2 is an irreversible inhibitor of FGFR1-4 with IC50 values of 3.1, 4.3, 27, and 45 nM, respectively.

FIIN-2 细胞实验

Cell Line H1581 cells (FGFR1 V561M mutant) Ba/F3 cells (FGFR2 V564M mutant) Ba/F3 cells (FGFR2-dependent) Ba/F3 cells (FGFR1-dependent) A549/DDP cells A549 cells PF179T CAFs CWR-R1 VCaP LNCaP Mouse ovarian cells H1581 cells LENTI-4 cells	Concentration	Treated Time	Description	References
H1581 cells (FGFR1 V561M mutant)	23.6 nM	96 hours	Evaluate the inhibitory effect of FIIN-2 on the proliferation of FGFR1 V561M mutant H1581 cells, showing an EC50 of 23.6 nM	Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4869-77.
Ba/F3 cells (FGFR2 V564M mutant)	58 nM	72 hours	Evaluate the inhibitory effect of FIIN-2 on the proliferation of FGFR2 V564M mutant Ba/F3 cells, showing an EC50 of 58 nM	Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4869-77.
Ba/F3 cells (FGFR2-dependent)	1 nM	72 hours	Evaluate the inhibitory effect of FIIN-2 on the proliferation of FGFR2-dependent Ba/F3 cells, showing an EC50 of 1 nM	Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4869-77.
Ba/F3 cells (FGFR1-dependent)	4 nM	72 hours	Evaluate the inhibitory effect of FIIN-2 on the proliferation of FGFR1-dependent Ba/F3 cells, showing an EC50 of 4 nM	Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4869-77.
A549/DDP cells	0-20 μmol/L	24 hours	FIIN-2 significantly inhibited the proliferation, colony formation, and migration of A549/DDP cells and induced mitochondria-mediated apoptosis.	Cell Death Dis. 2022 Aug 30;13(8):750.
A549 cells	0-20 μmol/L	24 hours	FIIN-2 significantly inhibited the proliferation, colony formation, and migration of A549 cells and induced mitochondria-mediated apoptosis.	Cell Death Dis. 2022 Aug 30;13(8):750.
PF179T CAFs	0.3 μM–10 μM	72 hours	Test the growth inhibitory effect of FIIN-2 on PF179T CAFs, results showed significant impact on cell viability at 10 μM concentration	Cancer Med. 2024 Sep;13(18):e70240.
CWR-R1	0.3 μM–10 μM	72 hours	Test the growth inhibitory effect of FIIN-2 on CWR-R1 cells, results showed effective growth inhibition at approximately 3 μM concentration	Cancer Med. 2024 Sep;13(18):e70240.
VCaP	0.3 μM–10 μM	72 hours	Test the growth inhibitory effect of FIIN-2 on VCaP cells, results showed approximately 70% inhibition at 3 μM concentration	Cancer Med. 2024 Sep;13(18):e70240.
LNCaP	0.3 μM–10 μM	72 hours	Test the growth inhibitory effect of FIIN-2 on LNCaP cells, results showed cytotoxicity at the highest concentration (10 μM)	Cancer Med. 2024 Sep;13(18):e70240.
Mouse ovarian cells	0.25 μM	5 days	To investigate the inhibitory effect of FIIN-2 on FGFRs and its impact on oocyte numbers. Results showed that inhibition of FGFRs led to a decrease in oocyte numbers and upregulated apoptosis levels in the ovaries.	J Biol Chem. 2023 Jun;299(6):104776.
H1581 cells	1 µM	6 hours	Evaluate the inhibitory effects of UPR1376 on H1581 cell proliferation	Front Oncol. 2019 Mar 26;9:179.
LENTI-4 cells	1 µM	1 hour	Evaluate the inhibitory effects of UPR1371-UPR1376 on FGFR1 auto-phosphorylation	Front Oncol. 2019 Mar 26;9:179.

Cell Line

Concentration

Treated Time

Description

References

H1581 cells (FGFR1 V561M mutant)

23.6 nM

96 hours

Evaluate the inhibitory effect of FIIN-2 on the proliferation of FGFR1 V561M mutant H1581 cells, showing an EC50 of 23.6 nM

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4869-77.

Ba/F3 cells (FGFR2 V564M mutant)

58 nM

72 hours

Evaluate the inhibitory effect of FIIN-2 on the proliferation of FGFR2 V564M mutant Ba/F3 cells, showing an EC50 of 58 nM

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4869-77.

Ba/F3 cells (FGFR2-dependent)

1 nM

72 hours

Evaluate the inhibitory effect of FIIN-2 on the proliferation of FGFR2-dependent Ba/F3 cells, showing an EC50 of 1 nM

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4869-77.

Ba/F3 cells (FGFR1-dependent)

4 nM

72 hours

Evaluate the inhibitory effect of FIIN-2 on the proliferation of FGFR1-dependent Ba/F3 cells, showing an EC50 of 4 nM

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4869-77.

A549/DDP cells

0-20 μmol/L

24 hours

FIIN-2 significantly inhibited the proliferation, colony formation, and migration of A549/DDP cells and induced mitochondria-mediated apoptosis.

Cell Death Dis. 2022 Aug 30;13(8):750.

A549 cells

0-20 μmol/L

24 hours

FIIN-2 significantly inhibited the proliferation, colony formation, and migration of A549 cells and induced mitochondria-mediated apoptosis.

Cell Death Dis. 2022 Aug 30;13(8):750.

PF179T CAFs

0.3 μM–10 μM

72 hours

Test the growth inhibitory effect of FIIN-2 on PF179T CAFs, results showed significant impact on cell viability at 10 μM concentration

Cancer Med. 2024 Sep;13(18):e70240.

CWR-R1

0.3 μM–10 μM

72 hours

Test the growth inhibitory effect of FIIN-2 on CWR-R1 cells, results showed effective growth inhibition at approximately 3 μM concentration

Cancer Med. 2024 Sep;13(18):e70240.

VCaP

0.3 μM–10 μM

72 hours

Test the growth inhibitory effect of FIIN-2 on VCaP cells, results showed approximately 70% inhibition at 3 μM concentration

Cancer Med. 2024 Sep;13(18):e70240.

LNCaP

0.3 μM–10 μM

72 hours

Test the growth inhibitory effect of FIIN-2 on LNCaP cells, results showed cytotoxicity at the highest concentration (10 μM)

Cancer Med. 2024 Sep;13(18):e70240.

Mouse ovarian cells

0.25 μM

5 days

To investigate the inhibitory effect of FIIN-2 on FGFRs and its impact on oocyte numbers. Results showed that inhibition of FGFRs led to a decrease in oocyte numbers and upregulated apoptosis levels in the ovaries.

J Biol Chem. 2023 Jun;299(6):104776.

H1581 cells

1 µM

6 hours

Evaluate the inhibitory effects of UPR1376 on H1581 cell proliferation

Front Oncol. 2019 Mar 26;9:179.

LENTI-4 cells

1 µM

1 hour

Evaluate the inhibitory effects of UPR1371-UPR1376 on FGFR1 auto-phosphorylation

Front Oncol. 2019 Mar 26;9:179.

FIIN-2 动物实验

Species Nude mice (BALB/c)	Animal Model A549/DDP xenograft model	Administration	Dosage	Frequency	Description	References
Nude mice (BALB/c)	A549/DDP xenograft model	Intraperitoneal injection	20 mg/kg	Twice daily for 28 days	FIIN-2 significantly suppressed tumor growth, and its cytotoxicity was enhanced when combined with the autophagy inhibitor CQ.	Cell Death Dis. 2022 Aug 30;13(8):750.

Species

Nude mice (BALB/c)

Animal Model

A549/DDP xenograft model

Administration

Dosage

Frequency

Description

References

Nude mice (BALB/c)

A549/DDP xenograft model

Intraperitoneal injection

20 mg/kg

Twice daily for 28 days

FIIN-2 significantly suppressed tumor growth, and its cytotoxicity was enhanced when combined with the autophagy inhibitor CQ.

Cell Death Dis. 2022 Aug 30;13(8):750.

FIIN-2 参考文献

FIIN-2 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.58mL

0.32mL

0.16mL

7.88mL

1.58mL

0.79mL

15.75mL

3.15mL

1.58mL

FIIN-2 技术信息

CAS号	1633044-56-0
分子式	C₃₅H₃₈N₈O₄
分子量	634.73
SMILES Code	C=CC(NC1=CC=C(CN(C2=NC(NC3=CC=C(N4CCN(C)CC4)C=C3)=NC=C2CN5C6=CC(OC)=CC(OC)=C6)C5=O)C=C1)=O
MDL No.	MFCD28386553

别名
运输	蓝冰

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, store in freezer, under -20°C

溶解方案

细胞实验：

DMSO: 30 mg/mL(47.26 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

方案三

靶点

靶点	数值

FGFR2	FGFR2, IC50:4.3 nM
FGFR3	FGFR3, IC50:27 nM
FGFR4	FGFR4, IC50:45.3 nM
FGFR1	FGFR1, IC50:3.09 nM

FIIN-2 {[allProObj[0].p_purity_real_show]}

FIIN-2 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

FIIN-2 质控信息

FIIN-2 生物活性

FIIN-2 细胞实验

FIIN-2 动物实验

FIIN-2 参考文献

FIIN-2 实验方案

FIIN-2 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

靶点	FGFR2 FGFR2, IC50:4.3 nM FGFR3 FGFR3, IC50:27 nM FGFR4 FGFR4, IC50:45.3 nM FGFR1 FGFR1, IC50:3.09 nM
描述	FIIN-2 is an irreversible inhibitor of FGFR1-4 with IC50 values of 3.1, 4.3, 27, and 45 nM, respectively.

FIIN-2 {[allProObj[0].p_purity_real_show]}

FIIN-2 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

FIIN-2 质控信息

FIIN-2 生物活性

FIIN-2 细胞实验

FIIN-2 动物实验

FIIN-2 参考文献

FIIN-2 实验方案

FIIN-2 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

请登录您的专属账户

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

FIIN-2 纯度/质量文件产品仅供科研