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货号 产品名 纯度
A494813 现货 ASP5878

ASP5878 是一种口服活性的 FGFR 1、2、3 和 4 的抑制剂,IC50 值分别为 0.47 nM、0.6 nM、0.74 nM 和 3.5 nM,具有潜在的抗肿瘤活性。

98%
A130690 现货 H3B-6527

H3B-6527 是一种口服活性、高选择性且共价的 FGFR4 抑制剂,IC50 小于 1.2 nM。它对 FGFR1-3 的 IC50 值分别为 320、1290 和 1060 nM。H3B-6527 表现出强大的抗癌活性。

99%+
A868383 现货 AZD-4547

AZD-4547(Fexagratinib ; ADSK091) 是一种有效的FGFR家族抑制剂,对FGFR1FGFR2FGFR3FGFR4IC50值分别为0.2 nM、2.5 nM、1.8 nM和165 nM。

98%
A724029 现货 Heparan Sulfate/硫酸乙酰肝素

Heparan sulfate是一种复杂的线性多糖。它作为硫酸乙酰肝素蛋白多糖的一部分,广泛表达在细胞表面和细胞外基质中。

>50.0 IU/mg
A160216 现货 Nintedanib esylate/乙磺酸尼达尼布

Nintedanib esylate (BIBF 1120 esylate) (BIBF 1120 esylate) 是一种有效的三重血管激酶抑制剂,对VEGFR1/2/3、FGFR1/2/3和PDGFRα/β的IC50值分别为34 nM/13 nM/13 nM、69 nM/37 nM/108 nM和59 nM/65 nM。

98%
A181556 现货 Nintedanib/尼达尼布

Nintedanib(BIBF 1120)是一种强效的三重血管激酶抑制剂,对VEGFR1/2/3、FGFR1/2/3和PDGFRα/β的IC50值分别为34 nM、13 nM、13 nM、69 nM、37 nM、108 nM、59 nM和65 nM。

99+%
A369272 现货 Brivanib (alaninate)

Brivanib alaninate (BMS-582664) 是一种 ATP 竞争性的 VEGFR2 抑制剂,IC50 为 25 nM;它对 VEGFR1FGFR1 具有中度抑制作用,对 VEGFR2 的选择性比对 PDGFRβ 高 240 倍。

99%+
A107926 现货 Infigratinib

Infigratinib(BGJ-398;NVP-BGJ398)对FGFR家族具有强效抑制作用,对FGFR1FGFR2FGFR3FGFR4IC50值分别为0.9 nM、1.4 nM、1 nM和60 nM。

99%+
A306611 现货 KW-2449

KW-2449 是一种多靶点激酶抑制剂,对FLT3ABLABLT315I和Aurora激酶的IC50值分别为6.6 nM、14 nM、4 nM和48 nM。

99%+
A714036 现货 S49076 hydrochloride

S49076 hydrochloride is a potent, ATP-competitive tyrosine kinase inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 <20 nM.

98%
A349538 现货 SSR128129E

SSR128129E is an allosteric modulator of FGFR by binding to the extracellular FGFR domain.

99%+
A709575 现货 JK-P3

99%+
A306554 现货 SKLB 610

99%+
A459806 现货 PD-089828

99%+
A500409 现货 Alofanib/阿洛法尼(RPT835)

Alofanib is a selective and allosteric inhibitor of FGFR2 with potential antitumor activity.

99%+
A1901672 现货 Zidesamtinib

99%+
A137706 现货 Fisogatinib

BLU-554 is a selective inhibitor of FGFR4 with the IC50 of 5 nM.

99%+
A339638 现货 PD-166866

PD 166866 is a selective FGFR tyrosine kinase inhibitor with an IC50 of 52.4 nM.

98%
A231990 现货 BLU9931

BLU9931 is an inhibitor of FGFR4 with IC50 of 3 nM and is less potent for FGFR1/2/3 (IC50 > 150 nM).

99%+
A303280 现货 Roblitinib

FGF401, an inhibitor of human fibroblast growth factor receptor 4 (FGFR4, IC50 = 1.1 nM), has potential antineoplastic activity.

99%+
产品名 FGFR FGFR1 FGFR2 FGFR3 FGFR4 其他靶点 纯度
Tyrphostin AG1296 +

FGFR (Swiss 3T3), IC50: 12.3 μM

PDGFR 99%+
Pazopanib +

FGFR, IC50: 140 nM

99%
Erdafitinib RET 99%+
Gambogenic acid 98+%
Sulfatinib +++

FGFR1, IC50: 15 nM

99+%
Nintedanib esylate +

FGFR1, IC50: 69 nM

++

FGFR2, IC50: 37 nM

+

FGFR3, IC50: 108 nM

98%
Zoligratinib +++

FGFR1, IC50: 9.3 nM

+++

FGFR2, IC50: 7.6 nM

++

FGFR3, IC50: 22 nM

+

FGFR4, IC50: 290 nM

99%+
MK-2461 +

FGFR1, IC50: 65 nM

++

FGFR2, IC50: 39 nM

++

FGFR3, IC50: 50 nM

99%+
SU 5402 ++

FGFR1, IC50: 30 nM

98%
Brivanib +

FGFR1, IC50: 148 nM

99%+
Lucitanib ++

FGFR1, IC50: 17.5 nM

+

FGFR2, IC50: 82.5 nM

99%+
Ponatinib ++++

FGFR1, IC50: 2.2 nM

98%
PD-166866 +

FGFR1, IC50: 52.4 nM

98%
Narazaciclib ++

FGFR1, IC50: 26 nM

RET 99%+
Lactate +++

FGFR1, IC50: 8 nM

+++

FGFR3, IC50: 9 nM

FLT3,c-Kit 85%
Lenvatinib mesylate ++

FGFR1, IC50: 46 nM

c-RET 99%
LY2874455 ++++

FGFR1, IC50: 2.8 nM

++++

FGFR2, IC50: 2.6 nM

+++

FGFR3, IC50: 6.4 nM

+++

FGFR4, IC50: 6 nM

99%+
FIIN-2 +++

FGFR1, IC50: 3.09 nM

+++

FGFR2, IC50: 4.3 nM

++

FGFR3, IC50: 27 nM

++

FGFR4, IC50: 45.3 nM

98%
FIIN-3 +++

FGFR1, IC50: 13.1 nM

++

FGFR2, IC50: 21 nM

++

FGFR3, IC50: 31.4 nM

++

FGFR4, IC50: 35.3 nM

98%
Infigratinib ++++

FGFR1, IC50: 0.9 nM

++++

FGFR2, IC50: 1.4 nM

++++

FGFR3, IC50: 1.0 nM

FGFR3 (K650E), IC50: 4.9 nM

+

FGFR4, IC50: 60 nM

99%+
Danusertib ++

FGFR1, IC50: 47 nM

RET 99%+
R1530 ++

FGFR1, IC50: 28 nM

98%
ENMD-2076 +

FGFR1, IC50: 92.7 nM

+

FGFR2, IC50: 70.8 nM

FLT3,RET 98%
Dovitinib +++

FGFR1, IC50: 8 nM

+++

FGFR3, IC50: 9 nM

FLT3,c-Kit 99%+
Sorafenib +

FGFR1, IC50: 580 nM

99%
SSR128129E +

FGFR1, IC50: 1.9 μM

99%+
AZD-4547 ++++

FGFR1, IC50: 0.2 nM

++++

FGFR2, IC50: 2.5 nM

++++

FGFR3, IC50: 1.8 nM

98%
Lenvatinib ++

FGFR1, IC50: 46 nM

RET 98%
PD173074 ++

FGFR1, IC50: ~25 nM

99%+
S49076 ++

FGFR1, IC50: 18 nM

+++

FGFR2, IC50: 17 nM

+++

FGFR3, IC50: 15 nM

99%+
Futibatinib ++++

FGFR1, IC50: 1.8 nM

++++

FGFR2, IC50: 1.4 nM

++++

FGFR3, IC50: 1.6 nM

+++

FGFR4, IC50: 3.7 nM

99%+
Ferulic Acid +

FGFR1, IC50: 3.78 μM

+

FGFR2, IC50: 12.5 μM

98%
Nintedanib +

FGFR1, IC50: 69 nM

++

FGFR2, IC50: 37 nM

+

FGFR3, IC50: 108 nM

+

FGFR4, IC50: 610 nM

99+%
ASP5878 ++++

FGFR1, IC50: 0.47 nM

++++

FGFR2, IC50: 0.6 nM

++++

FGFR3, IC50: 0.74 nM

+++

FGFR4, IC50: 3.5 nM

98%
PRN1371 ++++

FGFR1, IC50: 0.6 nM

++++

FGFR2, IC50: 1.3 nM

+++

FGFR3, IC50: 4.1 nM

++

FGFR4, IC50: 19.3 nM

99%
Derazantinib +++

FGFR1, IC50: 4.5 nM

++++

FGFR2, IC50: 1.8 nM

+++

FGFR3, IC50: 4.5 nM

++

FGFR4, IC50: 34 nM

RET 99%+
ODM-203 +++

FGFR1, IC50: 11 nM

+++

FGFR2, IC50: 16 nM

+++

FGFR3, IC50: 6 nM

++

FGFR4, IC50: 35 nM

99%+
Pemigatinib ++++

FGFR1, IC50: 0.4 nM

++++

FGFR2, IC50: 0.5 nM

++++

FGFR3, IC50: 1.2 nM

++

FGFR4, IC50: 30 nM

99%+
SKLB 610 PDGFR 99%+
Alofanib 99%+
Lirafugratinib 98%
Masitinib mesylate FAK 99%+
BLU9931 +

FGFR3, IC50: 150 nM

+++

FGFR4, IC50: 3 nM

99%+
BO-264 99%+
Fisogatinib +++

FGFR4, IC50: 5 nM

99%+
H3B-6527 ++++

FGFR4, IC50: <1.2 nM

99%+
Roblitinib ++++

FGFR4, IC50: 1.9 nM

99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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