Inhibited LPS-induced NO production, IC50=5.5 μg/ml
Br J Pharmacol. 2005 Oct;146(3):352-63
Mouse bone marrow-derived mast cells (BMMCs)
10 μM
24 hours
To evaluate the inhibitory effects of EC on DHNA-induced IL-6 production, results showed that EC inhibited DHNA-induced IL-6 production
Int J Mol Sci. 2023 Jun 10;24(12):9997
Mouse bone marrow-derived mast cells (BMMCs)
1 or 10 μM
12 hours
To evaluate the inhibitory effects of EC on AhR protein downregulation, results showed that EC inhibited FICZ-induced downregulation of AhR protein levels
Int J Mol Sci. 2023 Jun 10;24(12):9997
Mouse bone marrow-derived mast cells (BMMCs)
1 or 10 μM
2 hours
To evaluate the inhibitory effects of EC on AhR target gene expression, results showed that EC inhibited FICZ- or DHNA-induced Cyp1A1 mRNA expression
Int J Mol Sci. 2023 Jun 10;24(12):9997
HeXS34 reporter cells
10 μM
12 hours
To evaluate the inhibitory effects of EC on AhR activation, results showed that EC significantly inhibited FICZ- or DHNA-induced SEAP activity
Int J Mol Sci. 2023 Jun 10;24(12):9997
BALB/c splenocytes
10 μM
48 hours
To assess the effect of ECF on LPS-induced B cell proliferation, ECF inhibits B cell proliferation at 10 μM
J Immunol Res. 2017;2017:7416792
Purified T cells
0.1, 1, 10 μM
48 hours
To assess the effect of ECF on TCR crosslinking-mediated T cell proliferation, ECF significantly inhibits T cell proliferation
J Immunol Res. 2017;2017:7416792
BALB/c splenocytes
0.1, 1, 10 μM
48 hours
To assess the immunosuppressive effect of ECF in vitro, ECF significantly inhibits ConA-induced murine splenocyte proliferation
J Immunol Res. 2017;2017:7416792
HCC827OR cells
82 µM
48 hours
Inhibited migration and proliferation of HCC827OR cells, promoted apoptosis, and downregulated MET expression
Cancer Cell Int. 2025 Mar 15;25(1):99
PC9OR cells
78 µM
48 hours
Inhibited migration and proliferation of PC9OR cells, promoted apoptosis, and downregulated MET expression
Cancer Cell Int. 2025 Mar 15;25(1):99
RAW264.7 cells
75, 150, 300, 500 nM
2 hours
To investigate the effect of Ethyl Caffeate on NO production in LPS-induced RAW264.7 cells, results showed that Ethyl Caffeate significantly reduced extracellular NO levels.
Front Pharmacol. 2022 Feb 23;13:801350
RAW264.7 cells
20, 50, 100 μM
2 hours
Inhibited LPS-induced iNOS, IL-1β, and IL-10 mRNA expression
Molecules. 2011 Nov 10;16(11):9451-66
Ethyl Caffeate/咖啡酸乙酯 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6 mice
Passive cutaneous anaphylaxis (PCA) model
Oral
10 mg/kg
Single dose, evaluated after 24 hours
To evaluate the inhibitory effects of EC on PCA reaction, results showed that EC significantly inhibited ear swelling, Evans blue dye extravasation, and serum MCP-1 levels
Int J Mol Sci. 2023 Jun 10;24(12):9997
DBA/1 mice
Collagen-induced arthritis model
Oral
50 mg/kg
Once daily for 10 days
To investigate the antiarthritic potential of ECF, ECF treatment reduced the severity of CIA, inhibited IFN-γ and IL-6 secretion, and decreased the proportion of CD11b+Gr-1+ splenic neutrophil
J Immunol Res. 2017;2017:7416792
Ethyl Caffeate/咖啡酸乙酯 实验方案
计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
4.80mL
0.96mL
0.48mL
24.01mL
4.80mL
2.40mL
48.03mL
9.61mL
4.80mL
Ethyl Caffeate/咖啡酸乙酯 技术信息
CAS号
102-37-4
分子式
C11H12O4
分子量
208.21
SMILES Code
O=C(OCC)/C=C/C1=CC=C(O)C(O)=C1
MDL No.
MFCD00045754
别名
运输
蓝冰
InChI Key
WDKYDMULARNCIS-GQCTYLIASA-N
Pubchem ID
5317238
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formKeep in dark place,Inert atmosphere,2-8°C
搜索
