ERCC1-XPF-IN-2 | ERCC1-XPF Inhibitor | AmBeed-信号通路专用抑制剂

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ERCC1-XPF-IN-2 {[allProObj[0].p_purity_real_show]}

货号：A1671060

ERCC1-XPF-IN-2是一种高效的 ERCC1-XPF 核酸内切酶抑制剂，IC₅₀ 值为 0.6 μM。该化合物在核苷酸切除修复、顺铂增强疗效及 γH2AX 测定中表现出活性，适用于癌症和 DNA 损伤修复的研究。

ERCC1-XPF-IN-2 化学结构
CAS号：1808986-37-9

ERCC1-XPF-IN-2 3D分子结构
CAS号：1808986-37-9

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ERCC1-XPF-IN-2 纯度/质量文件产品仅供科研

货号：A1671060 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]; • Cell, 2025, 188, (21): 5847-5861.e11. Ambeed. [ A122167 ]; • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]; • Nat. Nanotechnol., 2025, 20, 1502-1513. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]; 更多 >

DNA 亚型比较

产品名称	DNA synthesis ↓ ↑	helicase ↓ ↑	RdRp ↓ ↑	ribonucleotide reductase ↓ ↑	tRNA synthetase ↓ ↑	YB-1 ↓ ↑	其他靶点	纯度
Fexinidazole	✔							98%
Daptomycin	✔							98%
Blasticidin S·HCl	✔							98%
Metronidazole	✔							98%
Daunorubicin HCl	+++ DNA synthesis, Ki: 20 nM							98%
Triglycidyl isocyanurate	✔						p53	98+%
Nedaplatin	✔							99%+
Oxolinic acid	✔							98+%
Bendamustine	✔							98+%
Trifluridine	✔							98%
Robinetin	✔							99%+
Carboplatin	✔							99%
Cidofovir	✔							99%
Cisplatin	✔							99%
Cytarabine	++++ DNA synthesis, IC50: 16 nM							98%
Acelarin	++++ DNA synthesis, EC50: 0.2 nM							99%+
Oxaliplatin	✔							98%
YK-4-279		✔						99%+
ML216		+ BLM^full-length, IC50: 2.98 μM BLM^636-1298, IC50: 0.97 μM						99%+
RK-33		✔						98%
Brr2-IN-3		✔						99%+
Phen-DC3 Trifluoromethanesulfonate		✔						98%
Favipiravir			✔					99%
Suramin sodium salt			++ RdRp, IC50: 0.26 μM					99%+
Clofarabine				++ Ribonucleotide reductase, IC50: 65 nM				97%
Didox				✔				98%
(E)-3-AP				✔				99%
Halofuginone					+++ prolyl-tRNA synthetase, Ki: 18.3nM			99%+
BC-LI-0186					+++ Leucyl-tRNA synthetase, IC50: 46.11 nM Leucyl-tRNA synthetase, Kd: 42.1 nM			98%
SU056						+ YB-1, IC50: 1.73 μM		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

ERCC1-XPF-IN-2 生物活性

描述

ERCC1-XPF-IN-2 is an effective ERCC1-XPF endonuclease inhibitor, exhibiting an IC50 of 0.6 µM. It is active in nucleotide excision repair, enhances cisplatin efficacy, and is involved in γH2AX assays^[1].

体外研究

ERCC1-XPF-IN-2, at concentrations between 0 and 100 µM, displays activities for FEN-1 and DNase I with IC50 values exceeding 100 µM for both^[1].

ERCC1-XPF-IN-2 exhibits slow binding kinetics with a dissociation constant (Kd) of approximately 30 µM^[1].

ERCC1-XPF-IN-2 is non-toxic to Hep-G2 cells at 10 µM and has short microsomal half-lives in mice and humans, with t1/2 values of 23 minutes and 28 minutes, respectively. Additionally, ERCC1-XPF-IN-2 (0-60 µM; 24 h) inhibits nucleotide excision repair (NER) in A375 cells with an IC50 of 15.6 µM^[1].

ERCC1-XPF-IN-2 enhances cisplatin efficacy without causing toxicity at concentrations ranging from 0 to 60 µM^[1].

ERCC1-XPF-IN-2 (10 µM; 6h) delays DNA repair, as indicated by an increase in the number of γH2AX foci per cell^[1].

ERCC1-XPF-IN-2 参考文献

[1]Chapman TM, et al. Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4097-103.

ERCC1-XPF-IN-2 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.07mL

0.61mL

0.31mL

15.33mL

3.07mL

1.53mL

30.66mL

6.13mL

3.07mL

ERCC1-XPF-IN-2 技术信息

CAS号	1808986-37-9
分子式	C₁₅H₁₃Cl₂NO₃
分子量	326.17
SMILES Code	O=C(NCC1=CC=C(O)C(O)=C1)CC2=CC=C(Cl)C=C2Cl
MDL No.	MFCD34676435

别名
运输	蓝冰

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, sealed in dry, 2-8°C

溶解方案

细胞实验：

DMSO: 250 mg/mL(766.46 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

ERCC1-XPF-IN-2 {[allProObj[0].p_purity_real_show]}

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