ERCC1-XPF-IN-2

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Chemical Structure| 1808986-37-9 同义名 : -
CAS号 : 1808986-37-9
货号 : A1671060
分子式 : C15H13Cl2NO3
纯度 : 98%
分子量 : 326.17
MDL号 : MFCD34676435
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(766.46 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 ERCC1-XPF-IN-2 is an effective ERCC1-XPF endonuclease inhibitor, exhibiting an IC50 of 0.6 µM. It is active in nucleotide excision repair, enhances cisplatin efficacy, and is involved in γH2AX assays[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.07mL

0.61mL

0.31mL

15.33mL

3.07mL

1.53mL

30.66mL

6.13mL

3.07mL
参考文献

[1]Chapman TM, et al. Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4097-103.