There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Dihydrotanshinone I, a natural product isolated and purified from the roots of Salvia miltiorrhiza Bge., exhibits dose-dependent inhibition towards HLM-catalyzed propofol glucuronidation.
Dihydrotanshinone I/二氢丹参酮I 细胞实验
Cell Line
Concentration
Treated Time
Description
References
4T1 cells
IC50: 6.97 μM
24 hours
Inhibited cell proliferation, IC50 of 6.97 μM
Int J Mol Sci. 2022 Dec 2;23(23):15180
8505C-PTX cells
2.5 µM
72 hours
Evaluate the effect of DHT on the viability of PTX-resistant cells, results showed DHT significantly reduced cell viability
Int J Mol Sci. 2021 Jul 28;22(15):8083
SW1736-PTX cells
2.5 µM
72 hours
Evaluate the effect of DHT on the viability of PTX-resistant cells, results showed DHT significantly reduced cell viability
Int J Mol Sci. 2021 Jul 28;22(15):8083
PMNs cells
0.5–128 μM
8 hours
Increased cell viability
Int J Mol Sci. 2022 Dec 2;23(23):15180
SKBR-3 cells
IC50: 17.87 μM
24 hours
Inhibited cell proliferation, IC50 of 17.87 μM
Int J Mol Sci. 2022 Dec 2;23(23):15180
MCF-7 cells
IC50: 34.11 μM
24 hours
Inhibited cell proliferation, IC50 of 34.11 μM
Int J Mol Sci. 2022 Dec 2;23(23):15180
MDA-MB-231 cells
IC50: 117.71 μM
24 hours
Inhibited cell proliferation, IC50 of 117.71 μM
Int J Mol Sci. 2022 Dec 2;23(23):15180
HCT116 cells
10 µM
15 days
To assess the inhibitory effect of DHTS on tumor spheroid growth
Nucleic Acids Res. 2017 Sep 19;45(16):9514-9527
HeLa cells
10 µM
To evaluate the interference of DHTS with HuR binding to target mRNAs
Nucleic Acids Res. 2017 Sep 19;45(16):9514-9527
NIH-3T3 fibroblasts
37.5, 75, 150 nM
12 hours
Blocking the downstream of CD44-RhoA-YAP signaling pathway, reducing YAP nuclear translocation, and inhibiting fibroblast migration, invasion, proliferation, and collagen deposition.
Theranostics. 2019 Jul 9;9(17):4993-5008
RAW264.7 macrophages
10, 50, 100 nM
24 hours
To evaluate the inhibitory effect of DHT on LPS-induced inflammatory response in macrophages, results showed DHT reduced the release of TNF-α and IL-1β and inhibited the activation of M1 macrophages
J Exp Clin Cancer Res. 2020 May 24;39(1):93
H9C2 cardiomyocytes
10 nM
24 hours
To evaluate the inhibitory effect of DHT on DOX-induced inflammatory response in cardiomyocytes, results showed DHT downregulated the expressions of p-NF-κB, TNF-α, and COX2
J Exp Clin Cancer Res. 2020 May 24;39(1):93
Rat primary hepatic stellate cells (pHSCs)
1, 5, 10 μmol/L
DHI dose-dependently inhibited the mRNA expression of various fibrogenic genes, including TGFβ1, α-SMA and COL1A1, in rat pHSCs.
Br J Pharmacol. 2017 May;174(10):1147-1160
LX-2 cells
1, 5, 10 μmol/L
DHI dose-dependently inhibited the mRNA expression of various fibrogenic genes, including TGFβ1, α-SMA and COL1A1, in LX-2 cells.
Br J Pharmacol. 2017 May;174(10):1147-1160
HL-60 cells
0.5~2.5 μg/mL
24 hours
DHTS significantly inhibited HL-60 cell proliferation, induced apoptosis, activated caspase-3, -8, and -9, leading to PARP cleavage.
Int J Mol Sci. 2015 Aug 17;16(8):19387-400
Dihydrotanshinone I/二氢丹参酮I 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
BALB/c nude mice
4T1 spontaneous metastasis model
Intraperitoneal injection
10 mg/kg or 20 mg/kg
Once daily for 25 days
Inhibited tumor growth and lung metastasis, lung fluorescence intensity decreased by 74.9% in DHT-H group
Int J Mol Sci. 2022 Dec 2;23(23):15180
Nude mice
HCT116 xenograft model
Intraperitoneal injection
10 mg/kg
Every 48 hours for 31 days
To evaluate the inhibitory effect of DHTS on tumor growth
Nucleic Acids Res. 2017 Sep 19;45(16):9514-9527
C57BL/6 mice
Crystalline silica-induced silicosis model
Intragastric administration
150, 75, 37.5 mg/kg
Once daily for 7 days
By blocking the CD44-RhoA-YAP signaling pathway, it alleviates crystalline silica-induced pulmonary fibrosis and improves pulmonary function.
Theranostics. 2019 Jul 9;9(17):4993-5008
C57BL/6 mice
Doxorubicin-induced cardiotoxicity model
Oral
20 mg/kg
Once daily for 4 weeks
To evaluate the protective effect of DHT on doxorubicin-induced cardiotoxicity, results showed DHT improved cardiac function, reduced inflammatory cell infiltration, and inhibited the activation of M1 macrophages and NF-κB signaling pathway
J Exp Clin Cancer Res. 2020 May 24;39(1):93
Sprague-Dawley rats
Bile duct ligation (BDL)-induced hepatic fibrosis model
Intraperitoneal injection
25 mg/kg/day
Once daily for 14 days
DHI treatment attenuated liver necrosis, bile duct proliferation and collagen accumulation, and reduced the expression of fibrogenesis-associated genes in BDL rats.
Br J Pharmacol. 2017 May;174(10):1147-1160
Nude mice
HL-60 xenograft model
Intraperitoneal injection
12.5 and 25.0 mg/kg
Once daily for one week
25 mg/kg DHTS significantly inhibited HL-60 tumor growth by about 68.0% with no effect on body weight.
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