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货号 产品名 纯度
A108483 现货 Tanshinone I/丹参酮I

Tanshinone I, an active principle isolated from the roots of Salvia miltiorrhiza (Danshen), is an inhibitor of type IIA human recombinant sPLA2 and rabbit recombinant cPLA2 with IC50s of 11 μM and 82 μM, respectively, is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells. Tanshinone I showed inhibitory effect on PL(pro) with IC50 value of 8.8μM and less inhibitory effect on 3CLpro with IC50 value of 38.7μM.

97%
A831392 现货 Dihydrotanshinone I/二氢丹参酮I

Dihydrotanshinone I, a natural product isolated and purified from the roots of Salvia miltiorrhiza Bge., exhibits dose-dependent inhibition towards HLM-catalyzed propofol glucuronidation. Dihydrotanshinone I showed inhibitory effect on PL(pro) with IC50 value of 4.9μM and less inhibitory effect on 3CLpro with IC50 value of 14.4μM.

99%+
A1251839 现货 GRL0617

GRL0617 is a noncovalent lead inhibitor of Plpro. It inhibited SARS-CoV viral replication in Vero E6 cells with an EC50 of 15μM。

99%+
A104838 现货 Tanshinone IIA/丹参酮IIA

Tanshinone IIA (Tan IIA) 是丹参根的主要成分之一,能够通过靶向 VEGF/VEGFR2蛋白激酶结构域来抑制血管生成。

97%
A255311 现货 Tanshinone IIA sulfonate sodium/丹参酮IIA-磺酸钠

Tanshinone IIA sulfonate sodium is a water-soluble derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca2+entry (SOCE), and is used to treat cardiovascular disorders.

98%
A393548 现货 6-Thioguanine/6-硫鸟嘌呤

6-Thioguanine belongs to the thiopurine family of drugs that also include mercaptopurine and azathioprine, which are examples of antimetabolites, and is a purine analogue of the nucleobase guanine. It was found to inhibit SARS-CoV PLpro. 6-Thioguanine disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.

98%
A189537 现货 6-Mercaptopurine hydrate/6-巯基嘌呤一水合物

6-Mercaptopurine Monohydrate inhibits the de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA, it is a widely used antileukemic agent and immunosuppressive drug. 6-mercaptopurine was found to inhibit SARS-CoV PLpro.

98%
A157592 现货 Cryptotanshinone/隐丹参酮

Cryptotanshinone是一种从丹参根中提取的天然化合物,通过抑制 STAT3 表现出抗肿瘤活性,IC50 为 4.6 μM。

98%
A560609 现货 Miltirone/丹参新酮

Rosmariquinone showed inhibitory effect on PL(pro) and 3CLpro with IC50 values of 30μM and 21.1μM, respectively.

98%
A642457 Tanshinone IIB

Tanshinone IIB (TSB), a natural product isolated and purified from the roots of Salvia miltiorrhiza, can significantly inhibit the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner. Tanshinone IIB showed inhibitory effect on PL(pro) with IC50 value of 10.7μM and less inhibitory effect on 3CLpro with IC50 value of 24.8μM.

98+%
A1256968 Methyl tanshinonate

Methyl tanshinonate showed inhibitory effect on PL(pro) with IC50 value of 9.2μM and less inhibitory effect on 3CLpro with IC50 value of 21.1μM.

98%
A1602730 Mpro/PLpro-IN-1

98%
A2792319 Dihydrotanshinone I/二氢丹参酮I

99%
A364816 Hirsutenone

Hirsutenone, a natural product isolated and purified from the eaves of Alnus nepalensis, exhibits anti-cancer effect against prostate cancer through a direct physical inhibition of Akt1/2, attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-L1 preadipocytes, underscoring the potential therapeutic application of Hirsutenone in preventing obesity, and may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone showed potent PL(pro) inhibitory activity with IC50 value of 4.1µM.

98+%
A2795727 GRL0617

99%
A2794056 Miltirone/丹参新酮

99%
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