Dihydrotanshinone I

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Chemical Structure| 87205-99-0 同义名 : 二氢丹参酮Ⅰ ;15,16-Dihydrotanshinone I; DHTS
CAS号 : 87205-99-0
货号 : A831392
分子式 : C18H14O3
纯度 : 99%+
分子量 : 278.3
MDL号 : MFCD28016070
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 2 mg/mL(7.19 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Dihydrotanshinone I, a natural product isolated and purified from the roots of Salvia miltiorrhiza Bge., exhibits dose-dependent inhibition towards HLM-catalyzed propofol glucuronidation.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.59mL

0.72mL

0.36mL

17.97mL

3.59mL

1.80mL

35.93mL

7.19mL

3.59mL
参考文献

[1]Cheung J, Beri V, Shiomi K, Rosenberry TL. Acetylcholinesterase complexes with the natural product inhibitors dihydrotanshinone I and territrem B: binding site assignment from inhibitor competition and validation through crystal structure determination. J Mol Neurosci. 2014 Jul;53(3):506-10.

[2]Cong M, Hu CM, et al. Cryptotanshinone and dihydrotanshinone I exhibit strong inhibition towards human liver microsome (HLM)-catalyzed propofol glucuronidation. Fitoterapia. 2013 Mar;85:109-13.