There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Crebanine, a natural product isolated and purified from the herbs of Stephania yunnanensis, can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, decrease the incidence of VF and CA by CaCl_2 in rats and by chloroform in mice, but has no proteetive effects on ouahain-indueed arrhythmias in guinea pigs. Crebanine also has potential utility of crebanine in the development of neurodegenerative therapy, might be used as the starting point to develop a drug for Alzheimer's disease, can inhibit the proliferation of human leukemic cells (HL-60, U937 and K562), human fibrosarcoma cells (HT1080) and cervix cancer cell lines (KB-3-1 and KB-V1 and it mediates cell cycle arrest at G0/G1 phase and this was associated with down-regulation of cyclins A and D.
Crebanine/克班宁 细胞实验
Cell Line
Concentration
Treated Time
Description
References
U87MG cells
0, 50, 100, 200 μM
48 h
To evaluate the effect of CB on GBM cell viability, results showed that CB dose-dependently reduced cell viability
Front Pharmacol. 2024 Jun 4;15:1419044
Osteoblast precursor cells (OPCs)
5 μM
48 h
To assess the cytotoxicity of CN on OPCs, results showed that CN did not exhibit significant cytotoxic effects on OPCs at concentrations below 5 μM.
J Cell Mol Med. 2024 Aug;28(16):e70044
bone marrow-derived monocytes (BMMs)
10 μM
48 h
To assess the cytotoxicity of CN on BMMs, results showed that CN did not exhibit significant cytotoxic effects on BMMs at concentrations below 15 μM.
J Cell Mol Med. 2024 Aug;28(16):e70044
HepG2 cells
35, 105, 175 µM
24 h
To detect the effect of Crebanine on the apoptosis of HepG2 cells, the results showed that Crebanine induced apoptosis by activating ROS and the mitochondrial pathway.
Front Pharmacol. 2023 Feb 16;14:1069093
HepG2 cells
35, 105, 175 µM
24 h
To observe the effect of Crebanine on the migration and invasion ability of HepG2 cells, the results showed that Crebanine significantly inhibited cell migration and invasion.
Front Pharmacol. 2023 Feb 16;14:1069093
HepG2 cells
35, 70, 105, 140, 175, 280 µM
24, 48, 72 h
To evaluate the inhibitory effect of Crebanine on the proliferation of HepG2 cells, the results showed that Crebanine significantly inhibited cell proliferation in a dose- and time-dependent manner.
Front Pharmacol. 2023 Feb 16;14:1069093
H22 cells
50-300 μg/mL
24 and 48 h
To evaluate the inhibitory effect of Crebanine and FA-Cre@PEG-PLGA NPs on the proliferation of H22 cells. The results showed that FA-Cre@PEG-PLGA NPs significantly enhanced the inhibitory effect on H22 cell proliferation under ultrasonic irradiation.
Int J Nanomedicine. 2024 Oct 17;19:10513-10536
Crebanine/克班宁 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
Xylene-induced ear edema model
Tail vein injection
5 mg/kg
Single administration
Cre inhibited xylene-induced ear edema in mice.
Front Pharmacol. 2023 Jan 4;13:1092583
C57BL/6J male mice
GC-induced femoral head necrosis model
Intramuscular injection
5 mg/kg
Three times per week for 3 weeks
To evaluate the therapeutic effect of CN on glucocorticoid-induced femoral head necrosis, results showed that CN significantly improved the trabecular structure of the femoral head.
J Cell Mol Med. 2024 Aug;28(16):e70044
Mice
CHCl3-induced ventricular fibrillation model
Caudal vein injection
5 mg/kg
Single dose
Evaluate the antiarrhythmic effects of Crebanine and its derivatives. Results showed that Crebanine at 5 mg/kg significantly reduced the incidence of ventricular fibrillation.
Molecules. 2016 Nov 28;21(12):1555
Sprague-Dawley rats and Kunming mice
Orthotopic hepatocellular carcinoma transplantation model
Tail vein injection
3 mg/kg
Administered every other day for 10 doses
To evaluate the tumor targeting and anti-tumor efficacy of FA-Cre@PEG-PLGA NPs under ultrasonic irradiation. The results demonstrated that FA-Cre@PEG-PLGA NPs significantly prolonged the retention time of the drug at the tumor site and exhibited superior anti-tumor effects under ultrasonic irradiation.
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