There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
(+)-Corynoline, a natural product isolated and purified from the tubers of Corydalis ambigua, is an acetylcholinesterase inhibitor.
Corynoline/紫蓳灵 细胞实验
Cell Line
Concentration
Treated Time
Description
References
human liver microsomes
50 μM
1 hour
To investigate the metabolism and bioactivation of CRL, and identify the CYP450 isoforms involved in reactive ortho-benzoquinone metabolites formation
Front Pharmacol. 2018 Nov 6;9:1264
rat liver microsomes
50 μM
1 hour
To investigate the metabolism and bioactivation of CRL, and identify the CYP450 isoforms involved in reactive ortho-benzoquinone metabolites formation
Front Pharmacol. 2018 Nov 6;9:1264
HepG2-C8-ARE luciferase cells
1, 2, 4 μM
24 h
To evaluate the induction of ARE transcriptional activity by Corynoline. Results showed that Corynoline significantly enhanced ARE transcriptional activity.
Molecules. 2016 Jul 27;21(8):975
RAW264.7 cells
1, 2, 4 μM
24 h
To investigate the inhibitory effect of Corynoline on NO, iNOS, and COX-2 in LPS-induced RAW264.7 cells. Results showed that Corynoline significantly reduced NO production and the mRNA and protein levels of iNOS and COX-2.
Molecules. 2016 Jul 27;21(8):975
rat primary osteoblasts
4 μM
2 days
To evaluate the protective effect of Corynoline on H2O2-induced oxidative stress injury, results showed that Corynoline downregulated intracellular ROS generation and restored the osteogenic potential of osteoblasts
Food Sci Nutr. 2023 Jan 24;11(4):2036-2048
Corynoline/紫蓳灵 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
BALB/c male mice
Hepatotoxicity evaluation model
Oral gavage
125-500 mg/kg
Single dose, evaluated at 24 h after administration
To evaluate the hepatotoxicity of CRL, results showed no obvious hepatotoxicity and did not induce acute liver injuries in the experimental dosage used in this study, but abnormal behaviors and low body temperature were observed
Front Pharmacol. 2018 Nov 6;9:1264
SD rats
OVX osteoporosis model
Not specified
10 mg/kg
8 weeks
To evaluate the alleviating effect of Corynoline on osteoporosis development, results showed that Corynoline significantly alleviated bone loss
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