KI696 异构体是 KI696 的低活性异构体。KI696 是一种高亲和力探针，可破坏 Keap1/NRF2 互作。

Omaveloxolone（RTA 408）是一种抗氧化炎症调节剂（AIM），可以激活Nrf2并抑制一氧化氮（NO）。它通过抑制STING依赖的NF-κB信号传导来减轻破骨细胞生成。

KI696是一种高亲和力探针，通过干扰Keap1/NRF2相互作用，作为该通路的高效且选择性抑制剂。

TBHQ（叔丁基对苯二酚）是一种广泛使用的Nrf2激活剂，通过激活Nrf2保护心脏免受阿霉素（DOX）诱导的心脏毒性。此外，TBHQ还是一种ERK激活剂，可以对抗脱氢紫堇碱（DHC）诱导的黑色素瘤细胞增殖抑制。

Sulforaphane天然存在于广泛食用的蔬菜中，增强肿瘤抑制蛋白的转录，抑制组蛋白去乙酰化酶的活性，激活Nrf2，并通过AMPK依赖信号通路抑制高糖诱导的胰腺癌进展。它表现出抗癌和抗炎活性。

RA-839 is a noncovalent small molecule binder to Keap1 and selective activator of Nrf2 signaling. RA-839 also suppresses LPS-induced iNOS and nitric oxide expression in macrophages.

Eriodictyol-7-O-glucoside, a natural product isolated and purified from the herbs of Dracocephalum rupestre, can activate Nrf2/ARE signaling, directly associated with its neuroprotection against oxidative stress-induced ischemic, suggesting that targeting the Nrf2/ARE pathway may be a promising approach for therapeutic intervention in stroke.

Carnosol, a natural product isolated and purified from the herbs of Rosmarinus officinalis L., enhances the sensitivity of chemoresistant cancer cells to chemotherapeutic agents. Carnosol may as an agonist of TRPA1 with an EC50 value of 12.46 µM.

Mangiferin is the predominant constituent of extracts of the mango plant Mangifera Indica L. with potential antidiabetic activity.

Oxysophocarpine, a natural product isolated and purified from the root of Styphnolobium japonicum (L.) Schott., can decrease the level of serum transaminase, improve lipid metabolism, reduce synthesis of inflammatory cytokines TNF-α, TGF-β1 and IL-6, activate protective adipocytokine adiponectin, and may be a drug for colonic inflammation and NASH.

ML-385 is a selective inhibitor of NRF2 via binding to Neh1 DNA binding domain with IC50 of 1.9 µM.

(+)-Corynoline is an AChE inhibitor isolated from Corydalis incisa.

4-Octyl itaconate is the endogenous metabolite of itaconate with anti-inflammatory activity. It can decrease cytokine production and protect against lipopolysaccharide-induced lethality in vivo.